Article
Pharmacology & Pharmacy
Agathe Thouvenin, Balthazar Toussaint, Jelena Marinovic, Anne-Laure Gilles, Amelie Dufay Wojcicki, Vincent Boudy
Summary: This study designed a smart formulation of (S)-ketamine for buccal administration to improve absorption by increasing contact with mucosa components. Rheological and mucoadhesion tests were conducted to determine the optimal concentrations and components of the formulation. The study also found that batch-to-batch variability did not have a significant impact on drug release profile. This optimized formulation has fast release and potential clinical value, especially in emergencies.
Article
Pharmacology & Pharmacy
Shaolong He, Jette Jacobsen, Carsten Uhd Nielsen, Natalja Genina, Jesper Ostergaard, Huiling Mu
Summary: This study examines two release testing methods to characterize buccal films and the relationship between microenvironmental pH (pHM) and saquinavir release. Results show that films containing HPMC K3 LV have faster saquinavir release compared to films with HPMC K100 LV, and an increase in malic acid content can accelerate saquinavir release. The combination of methods may have broad applications in buccal formulation development, with the imaging approach showing promise for characterizing pH modifying formulation principles.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Krisztian Pamlenyi, Geza Regdon, Daniel Nemes, Ferenc Fenyvesi, Ildiko Bacskay, Katalin Kristo
Summary: Oral mucoadhesive systems, such as polymer films, are innovative pharmaceutical products that can be used in swallowing problems, geriatrics and paediatrics. This study investigated the stability and permeability of buccal mucoadhesive polymer films containing cetirizine-hydrochloride as the API. The films showed adequate stability, high cell viability and appropriate absorption properties.
Article
Food Science & Technology
Hui Wang, Jinming Liu, Xu Fan, Jing Ren, Qian Liu, Baohua Kong
Summary: In this study, high strength sodium alginate (NaAlg) hydrogel films were obtained using natural crab-shell particles (CSP) and deacetylated crab-shell particles (dCSP) as crosslinking agents. The bi-crosslinked NaAlg hydrogel films demonstrated superior surface hydrophobicity, gel properties, mechanical strength, and thermal stabilities compared to neat NaAlg film and mono-crosslinked NaAlg hydrogel films. Additionally, these hydrogel films exhibited sustained release activity for diclofenac sodium for over 36 hours. This green crosslinking technique shows promise for the development of high-performance NaAlg hydrogel films for food packaging and medical wound dressing applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Bissera Pilicheva, Yordanka Uzunova, Maria Marudova
Summary: The goal of this research was to explore the potential of polyelectrolyte multilayers as buccal dosage forms and study the impact of drug properties on the delivery system's performance. Multilayer films based on the interaction between casein and chitosan were developed using benzydamine, tolfenamic acid and betahistine as model drugs. The samples exhibited non-irritation, physical stability, and mucoadhesion, making them an ideal delivery system for sparingly soluble drugs.
Article
Pharmacology & Pharmacy
Raul Diaz-Salmeron, Balthazar Toussaint, Nicolas Huang, Etienne Bourgeois Ducournau, Gabriel Alviset, Sophie Goulay Dufay, Herve Hillaireau, Amelie Dufay Wojcicki, Vincent Boudy
Summary: Oral lichen planus is a chronic inflammatory disease treated with corticosteroid-containing formulations, but this administration route has limitations. The development of a new pharmaceutical formulation with mucoadhesive, sprayable, sustained, and controlled release properties may overcome these limitations for more effective treatment.
Review
Chemistry, Multidisciplinary
Lewis Shipp, Fang Liu, Laxmi Kerai-Varsani, Tochukwu C. Okwuosa
Summary: The mucoadhesive film technology shows great potential in terms of patient acceptability and therapeutic opportunities, especially for those with swallowing difficulties. However, the commercial translation of this technology is currently limited. This review provides an overview of mucoadhesive buccal film technology and identifies areas of focus to facilitate its wider adoption. It also discusses patient-related factors, manufacturing methods, and polymers used in film formulations. Additionally, the importance of physiologically relevant in vitro evaluation methods is emphasized.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Viviana De Caro, Giuseppe Angellotti, Fabio D'Agostino, Giulia Di Prima
Summary: This study aimed to design CYT-loaded buccal thin films that can promote the interaction between CYT and buccal mucosa for transbuccal drug delivery. Several compositions were prepared using the solvent casting method, and four of them showed promising aspects and flexibility. These films demonstrated homogeneity, thinness, low swelling degree, and controlled drug release, and exhibited mucoadhesive effects and potent permeation enhancement when tested on ex vivo porcine buccal mucosa.
Article
Pharmacology & Pharmacy
Karin Korelc, Bjarke Strom Larsen, Mirjana Gasperlinb, Ingunn Tho
Summary: Oromucosal films and wafers are convenient solid dosage forms for drug delivery. In this study, prednisolone containing chitosan-based mucoadhesive films and wafers were developed with different chitosan types. The mucoadhesive properties, drug release rate, and permeability of the formulations were evaluated. The results showed that chitosan type, solvent, and preparation method influenced the mucoadhesive properties, drug release rate, and permeability. The mucoadhesive wafers with a slower drug release rate and stronger mucoadhesion were considered promising alternatives to films.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Suping Ji, Rui Sun, Wenjuan Wang, Qiang Xia
Summary: A new buccal film composed of tamarind seed polysaccharide (TSP) and carboxymethylcellulose (CMC) was created for delivering soybean peptides through the mucosa. Soybean peptides-chitosan nanoparticles (SP-CS) were incorporated into the TSP-CMC film to enhance the release of soybean peptides in the mouth. The addition of SP-CS improved the flexibility of the film and disrupted hydrogen bonding between the film matrices, resulting in a loose internal structure and increased swelling ability. The release test indicated that the initial burst release of soybean peptides was suppressed when the concentration of SP-CS exceeded 1%, but low levels of SP-CS (1%-3%) increased the cumulative release compared to the film without SP-CS. These findings suggest that TSP-CMC films containing SP-CS have potential for efficient soybean peptide delivery.
FOOD HYDROCOLLOIDS
(2023)
Article
Pharmacology & Pharmacy
Elena Dinte, Dana Maria Muntean, Vlad Andrei, Bianca Adina Bosca, Cristian Mircea Dudescu, Lucian Barbu-Tudoran, Gheorghe Borodi, Sanda Andrei, Adrian Florin Gal, Vasile Rus, Luciana-Madalina Gherman, Oana Cadar, Reka Barabas, Mihaela Niculae, Aranka Ilea
Summary: This study prepared mucoadhesive films containing doxycycline hyclate for application in the oral cavity. The films exhibited good release properties and showed therapeutic effectiveness in experimental periodontitis.
Article
Pharmacology & Pharmacy
Marija Jovanovic, Milos Petrovic, Sandra Cvijic, Natasa Tomic, Dusica Stojanovic, Svetlana Ibric, Petar Uskokovic
Summary: Gelatin-based mucoadhesive buccal films loaded with propranolol hydrochloride were prepared using semi-solid extrusion 3D printing, with different effects on thermal and mechanical properties and drug release profiles observed for formulations containing PVP and PVA synthetic polymers.
Review
Pharmacology & Pharmacy
Apipa Wanasathop, Priya B. Patel, Hyojin A. Choi, S. Kevin Li
Summary: An in-depth review of permeability data of porcine buccal mucosa revealed significant variability, with correlations observed between permeability coefficients and factors such as octanol/water partition coefficients, molecular weight, and effective pore radius for the buccal membrane barrier.
Article
Biochemistry & Molecular Biology
Li Ming Lim, Kunn Hadinoto
Summary: This study found that hydroxypropyl starch is a suitable mucoadhesive polysaccharide for high-payload buccal film applications, with excellent CUR release characteristics and stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Helton Jose Wiggers, Pascale Chevallier, Francesco Copes, Fernanda Heloisa Simch, Felipe da Silva Veloso, Giovana Maria Genevro, Diego Mantovani
Summary: Natural polymer-based films, specifically chitosan films, have been extensively studied as coatings for biomedical applications due to their favorable biological and mechanical properties. In this study, chitosan films crosslinked with quercetin were used as controlled release systems for the antibiotic drug trimethoprim. The results show that quercetin increases the crosslinking degree of chitosan films in a dose-dependent manner, affecting the release kinetics of the loaded drug while maintaining its antibacterial effects. This work demonstrates the potential of quercetin-crosslinked chitosan films as antibiotic-releasing coatings for biomedical applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Calvin A. Omolo, Nagia A. Megrab, Rahul S. Kalhapure, Nikhil Agrawal, Mahantesh Jadhav, Chunderika Mocktar, Sanjeev Rambharose, Kaminee Maduray, Bongani Nkambule, Thirumala Govender
Summary: pH-responsive liposomes with 'On' and 'Off' switches were developed for infection site targeting, showing enhanced drug release and antimicrobial effects, resulting in reduced intracellular infections.
JOURNAL OF LIPOSOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mohammed Salih, Pavan Walvekar, Calvin A. Omolo, Ahmed A. Elrashedy, Nikita Devnarain, Victoria Fasiku, Ayman Y. Waddad, Chunderika Mocktar, Thirumala Govender
Summary: This study synthesized a novel PEG-FA conjugate, self-assembled into nanostructures for enhanced solubility and antibacterial activity of fusidic acid. The PEG-FA showed improved biosafety compared to FA, increased water solubility by 25-fold, and enhanced antibacterial activity by 2.5-fold against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Nanoscience & Nanotechnology
Nikita Devnarain, Nawras Osman, Victoria Oluwaseun Fasiku, Sifiso Makhathini, Mohammed Salih, Usri H. Ibrahim, Thirumala Govender
Summary: Stimuli-responsive nanocarriers have become a focus of research due to their enhanced activity, improved targeted delivery, and superior potential for bacterial penetration and eradication. These nanocarriers have the ability to release drugs specifically, and hold great promise as important tools for future antibacterial therapy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Letter
Immunology
D. Lutchman, G. A. Varigos
IMMUNOLOGY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Victoria O. Fasiku, Calvin A. Omolo, Nikita Devnarain, Usri H. Ibrahim, Sanjeev Rambharose, Mbuso Faya, Chunderika Mocktar, Sanil D. Singh, Thirumala Govender
Summary: Chronic wound infections caused by antibiotic-resistant bacteria are a global health concern due to biofilm-forming ability. Conventional approaches for biofilm wounds are ineffective, necessitating more efficient interventions. Hydrogen peroxide combined with antimicrobial peptides shows promise in combating bacterial biofilms and improving wound healing.
Editorial Material
Health Care Sciences & Services
V. Bangalee, O. Garza, F. Oosthuizen, V. Perumal-Pillay, H. Rotundo
Summary: During the pandemic, social distancing has become a global norm for keeping people safe, leading to compulsory lockdowns and disruptions in higher education, including pharmacy education. Collaborating educators from different countries with existing partnerships have identified common challenges and benefited from sharing potential solutions.
AFRICAN JOURNAL OF HEALTH PROFESSIONS EDUCATION
(2021)
Article
Health Policy & Services
Lirosha Moodley, Fatima Suleman, Velisha Ann Perumal-Pillay
Summary: This study reported on the decision-making processes of healthcare budget and its translation into pharmaceutical expenditure in South Africa. Various factors were considered to inform the budget, with the Standard Treatment Guidelines and Essential Medicines List being the primary guides for medicine provision. The process was well-controlled and monitored by the pharmaceutical therapeutics committee. Documenting the South African experience may benefit other countries in their medication budget decisions.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2021)
Review
Nanoscience & Nanotechnology
Nawras Osman, Nikita Devnarain, Calvin A. Omolo, Victoria Fasiku, Yajna Jaglal, Thirumala Govender
Summary: This article discusses the techniques of enhancing nanocarriers loaded with antibacterial agents through surface modification, and describes the use of various coating materials to achieve more effective delivery and increased bioavailability at the site of infection.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Health Policy & Services
Shannice Mahadeo, Keshmika Narain, Lungelo Mhlongo, Desmaine Chetty, Lindelani Masondo, Mandla Zungu, Fatima Suleman, Velisha Ann Perumal-Pillay
Summary: This study investigated the accessibility, availability, and affordability of priority medicines for children under 5 years in public and private pharmacies in eThekwini Metropolitan area, South Africa. Results showed that these medicines were accessible and affordable in most pharmacies, with better availability and affordability in the public sector.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2022)
Article
Health Policy & Services
Tashni Govender, Fatima Suleman, Velisha Ann Perumal-Pillay
Summary: The majority of doctors had access to the latest STGs/EML, while only a small percentage of nurses did. 70.3% and 78.3% of doctors' and nurses' prescriptions, respectively, adhered to the guidelines. Most nurses expressed the need for training on the use of STGs/EML.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2021)
Article
Health Policy & Services
Adetola Olaniyi Bojuwoye, Fatima Suleman, Velisha Ann Perumal-Pillay
Summary: This study aimed to investigate the level of polypharmacy and potential drug-drug interactions among geriatric patients in a South African hospital. The results showed a high rate of polypharmacy and potential drug interactions. Polypharmacy was identified as the strongest contributor to potential drug-drug interactions. Therefore, improving medication use and minimizing potential drug interactions is crucial for geriatric patients.
JOURNAL OF PHARMACEUTICAL POLICY AND PRACTICE
(2022)
Review
Nanoscience & Nanotechnology
Mahir Mohammed, Nikita Devnarain, Eman Elhassan, Thirumala Govender
Summary: Hyaluronic acid (HA) is a popular material for drug delivery research due to its excellent properties. This article reviews the various techniques of preparing HA-based nanoparticles and discusses their applications in antibacterial delivery. The potential of HA-based nanoparticles in overcoming the challenges of conventional antibiotics is highlighted.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Velisha A. Perumal-Pillay, Fatima Suleman
Summary: The essential medicines concept, implemented in South Africa in 1996, aimed to address inequities in medicines access and use, but these inequities still persist. The implementation of the new National Health Insurance scheme is expected to alleviate this healthcare inequity.
SOUTH AFRICAN FAMILY PRACTICE
(2021)
Article
Education, Scientific Disciplines
Varsha Bangalee, Frasia Oosthuizen, Velisha Ann Perumal-Pillay, Fatima Suleman, Fiona Walters
Summary: The study found that playing the game improved understanding and application of knowledge, promoted sharing of knowledge and collaboration, and enhanced learners' ability to think and communicate concisely and quickly. However, the competitive aspect of the game was seen as the main negative. Suggestions for improvement included shortening the game, including mixed groups of students from different levels of study, and introducing a referee to oversee the game.
CURRENTS IN PHARMACY TEACHING AND LEARNING
(2021)
Review
Cell Biology
Amit Pant, Irene Mackraj, Thirumala Govender
Summary: Nanotechnology presents promising solutions for sepsis management through rapid and accurate diagnosis using nanosensors and targeted treatment with nanoparticle drug delivery systems. By improving antibiotic delivery and enhancing targeting of pathogens, nanotechnology can help combat drug resistance in sepsis.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
