Article
Chemistry, Multidisciplinary
Christopher M. Brown, Keith E. L. Husted, Yuyan Wang, Landon J. Kilgallon, Peyton Shieh, Hadiqa Zafar, David J. Lundberg, Jeremiah A. Johnson
Summary: Using ring-opening metathesis polymerization, terpolymers were synthesized consisting of a functional monomer, a monomer with an electrophilic pentafluorophenyl substituent, and a cleavable monomer based on bifunctional silyl ether. Exposing these polymers to thiols under basic conditions triggers nucleophilic aromatic substitution reactions, liberating fluoride ions and causing backbone deconstruction. This method effectively deconstructs polyethylene glycol-based graft terpolymers and polydicyclopentadiene thermosets, significantly expanding the versatility of bifunctional silyl ether-based functional polymers.
Article
Polymer Science
Marta Grochowicz, Lukasz Szajnecki, Magdalena Rogulska
Summary: This study presents the use of new polymeric porous microspheres based on 4-vinylpyridine for the preconcentration and removal of ibuprofen and ketoprofen. The microspheres show different sorption capacities depending on the pH conditions, with higher affinity towards ibuprofen. The recovery of the drugs after dynamic sorption experiments was found to be greater than 90%.
Article
Chemistry, Multidisciplinary
Mehmet Mart, Idris Karakaya, Janusz Jurczak
Summary: A direct and atom-economic method was developed to accomplish the amidation of nonsteroidal anti-inflammatory drugs naproxen, ibuprofen and ketoprofen with various secondary amines using commercially available DCC under mild and open-air conditions. The prodrug amides were obtained with good to moderate yields ranging between 30-90%.
Article
Materials Science, Multidisciplinary
Mateusz Pawlaczyk, Grzegorz Schroeder
Summary: The study successfully synthesized the dual-polymeric material PMVEAMA-PAMAM and demonstrated its excellent performance in adsorbing analytes such as Congo Red and folic acid, with high reusability for dye scavenging. Additionally, the research results also showed the potential of this material in drug delivery applications.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Polymer Science
Giulia De Negri Atanasio, Pier Francesco Ferrari, Roberta Campardelli, Giuseppe Firpo, Patrizia Perego, Domenico Palombo
Summary: This study compares the performance of three different biocompatible and biodegradable polymers for the production of microparticles for drug delivery. The characteristics of the microparticles, release of the drug, and cell viability were investigated.
Article
Chemistry, Organic
Mansi Sharma, Ishani Bose, Yan Zhao
Summary: In this work, nanoparticle catalysts with accurately positioned carboxylic acids are reported, achieved through either covalent or noncovalent imprinting technique. The rationally designed active site enables highly selective or unselective catalysis towards the substrate. With the appropriate catalyst, hydrolysis can proceed smoothly in neutral water or slightly basic solution at room temperature.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yufei Cao, Jiale Si, Moujiang Zheng, Qinghao Zhou, Zhishen Ge
Summary: Radiotherapy is widely used in the treatment of various cancers and has the advantages of precise controllability and deep tissue penetration. However, it is limited by side effects and tumor hypoxia. The combination of radiotherapy and other modalities can improve therapeutic efficacy and reduce toxicity.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yudai Morota, Takanaga Suzuki, Kira B. Landenberger
Summary: Halogen bonding is recognized as an important intermolecular interaction in supramolecular chemistry. This study developed three new vinyl ether monomers containing halogen bonding donor moieties to facilitate cationic polymerization, using a proton trap and a co-Lewis acid to accelerate the reaction. The polymerization rate was influenced by the chain length, with C4I exhibiting the most pronounced halogen bonding.
Article
Pharmacology & Pharmacy
Xinran Zhang, Li Yin Chau, Ho Wan Chan, Jingwen Weng, Ka Wai Wong, Shing Fung Chow, Albert Hee Lum Chow
Summary: The study successfully prepared polymeric IBP nanoparticles using flash nanoprecipitation technology, and found that the nanoparticles could enhance the delivery of IBP into the brain. However, some nanoparticles may face the issue of rapid release into the bloodstream following intravenous administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Polymer Science
Tadashi Naito, Arihiro Kanazawa, Sadahito Aoshima
Summary: In this study, alternating cationic copolymerizations were investigated to obtain polymers with ABCC-type monomer sequences, which were prepared from the reaction of 2-chloroethyl vinyl ether (CEVE) and cyclic trimers. The kinds of vinyl monomers and aldehyde molecules incorporated into the cyclic trimers affected the copolymerization frequencies with CEVE, and a cyclic trimer consisting of isobutyl VE (IBVE) and 2-nonenal (NNE) showed highly effective alternating copolymerizations with CEVE at appropriate monomer concentrations. Structural analysis of the methanolysis products revealed mainly ABCC-type periodic sequences (83% under optimized conditions).
Review
Pharmacology & Pharmacy
Gianni Pecorini, Elisabetta Ferraro, Dario Puppi
Summary: This article provides an updated overview of scientific literature on polymeric systems developed for the controlled release of flavonoids. It describes different classes of flavonoids and commonly used polymers for drug delivery. Representative drug delivery systems and their preparation techniques are discussed. The flavonoids investigated for polymer system encapsulation are presented with their main source of extraction and biological properties. Relevant literature on their employment in targeted pharmacological and biomedical applications is reviewed.
Article
Nanoscience & Nanotechnology
Bashayer S. Aldakkan, Mohamed A. Hammami, Genggeng Qi, Mazen Y. Kanj, Emmanuel P. Giannelis
Summary: The study demonstrates a stimuli-responsive, sub-100 nm nanoparticle platform for in-situ generation of surfactants, and investigates the release kinetics of surfactants through hydrolysis. The released surfactant is efficient in reducing interfacial tension, altering wettability, and stabilizing oil-water emulsion.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Kerr D. G. Samson, Eleonore C. L. Bolle, Mariah Sarwat, Tim R. Dargaville, Ferry P. W. Melchels
Summary: This study focused on developing an osmotically triggered delayed delivery device to improve the efficiency of single-administration vaccine delivery systems. Factors controlling the release delay were characterized, with adjustments in material permeability and device wall thickness shown to be advantageous for maintaining reproducibility. The photo-cured poly(epsilon-caprolactone) network showed full degradability in vitro and no cytotoxicity after direct contact with dermal fibroblasts for 11 days, supporting further development of flexible biomaterials for in vivo vaccine booster delivery.
Article
Chemistry, Multidisciplinary
Wuryanto Hadinugroho, Suwaldi Martodihardjo, Achmad Fudholi, Sugeng Riyanto, Jefri Prasetyo
Summary: This study increased the release of ketoprofen in controlled-release granules by manipulating the gel conditions and angle values.
Article
Pharmacology & Pharmacy
Anuradha Gupta, Jungmi Lee, Torsha Ghosh, Van Quy Nguyen, Anup Dey, Been Yoon, Wooram Um, Jae Hyung Park
Summary: This review discusses the advantages and drawbacks of polymeric materials and their modifications for fabricating hydrogels loaded with therapeutic agents. It emphasizes the biological potential of hydrogel hybrid systems and the application of facile tuning of therapeutic drug loading and long-term release. It also suggests the advantages, challenges, and future perspectives of hydrogels loaded with anti-arthritic agents in arthritis treatment.
Article
Chemistry, Multidisciplinary
Esmail Vessally, Ebrahim Ghorbani-Kalhor, Rahim Hosseinzadeh-Khanmiri, Mirzaagha Babazadeh, Akram Hosseinian, Fariborz Omidi, Mohammad Hossein Ebrahimi
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2018)
Article
Chemistry, Applied
Rahim Hosseinzadeh-Khanmiri, Yaser Kamel, Zahra Keshvari, Ahmad Mobaraki, Gholam Hossein Shahverdizadeh, Esmail Vessally, Mirzaagha Babazadeh
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Review
Chemistry, Organic
Esmail Vessally, Mirzaagha Babazadeh, Akram Hosseinian, Ladan Edjlali, Lakshmaiah Sreerama
CURRENT ORGANIC CHEMISTRY
(2018)
Review
Chemistry, Organic
Esmail Vessally, Mirzaagha Babazadeh, Khadijeh Didehban, Akram Hosseinian, Ladan Edjlali
CURRENT ORGANIC CHEMISTRY
(2018)
Review
Chemistry, Organic
Esmail Vessally, Akram Hosseinian, Mirzaagha Babazadeh, Ladan Edjlali, Rahim Hosseinzadeh-Khanmiri
CURRENT ORGANIC CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Rayehe Bagheri, Mirzaagha Babazadeh, Esmail Vessally, Moosa Es'haghi, Ahmadreza Bekhradnia
INORGANIC CHEMISTRY COMMUNICATIONS
(2018)
Article
Biochemical Research Methods
A. Hosseinian, E. Vessally, M. Babazadeh, L. Edjlali, M. Es'haghi
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
(2018)
Article
Chemistry, Multidisciplinary
Akram Hosseinian, Esmail Vessally, Mirzaagha Babazadeh, Ladan Edjlali, Moosa Es'haghi
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2018)
Article
Chemistry, Multidisciplinary
Esmail Vessally, Khadijeh Didehban, Robab Mohammadi, Akram Hosseinian, Mirzaagha Babazadeh
JOURNAL OF SULFUR CHEMISTRY
(2018)
Review
Chemistry, Organic
Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh, Khadijeh Didehban
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2018)
Review
Chemistry, Multidisciplinary
Khadijeh Didehban, Esmail Vessally, Mina Salary, Ladan Edjlali, Mirzaagha Babazadeh
JOURNAL OF CO2 UTILIZATION
(2018)
Review
Chemistry, Multidisciplinary
Esmail Vessally, Robab Mohammadi, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh
JOURNAL OF CO2 UTILIZATION
(2018)
Review
Chemistry, Organic
Akram Hosseinian, Mirzaagha Babazadeh, Ladan Edjlali, Zahra Rahmani, Esmail Vessally
CURRENT ORGANIC SYNTHESIS
(2018)
Article
Chemistry, Inorganic & Nuclear
Robabeh Moghadami, Esmail Vessally, Mirzaagha Babazadeh, Moosa Es'haghi, Ahmadreza Bekhradnia
JOURNAL OF CLUSTER SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Esmail Vessally, Akram Hosseinian, Ladan Edjlali, Mirzaagha Babazadeh, Rahim Hosseinzadeh-Khanmiri
IRANIAN JOURNAL OF CHEMISTRY & CHEMICAL ENGINEERING-INTERNATIONAL ENGLISH EDITION
(2017)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)