Article
Health Care Sciences & Services
Angela Rizzi, Giuseppe Parrinello, Eugenio De Corso, Laura Tricarico, Michele Centrone, Alessia Di Rienzo, Chiara Laface, Giulio Cesare Passali, Gabriella Cadoni, Riccardo Inchingolo, Gaetano Paludetti, Jacopo Galli, Eleonora Nucera
Summary: The study confirms the effectiveness of intranasal mometasone furoate in patients with NAR, with improvements in olfactory function and quality of life observed as therapeutic responses.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Min Zhang, Jing-Zi Ni, Lei Cheng
Summary: Intranasal corticosteroids (INCSs) have a favorable safety profile and high local-systemic balance of bioavailability with a low incidence of adverse events in the treatment of pediatric allergic rhinitis (AR). However, the use of INCSs should be individualized based on patient response and adverse effects. Evaluation of the benefits and risks of INCSs is necessary to ensure clinical efficacy and prevent potential events.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Allergy
Maria Doulaptsi, Tine Wils, Peter W. Hellings, Katleen Martens, Ricard Farre, Maria Vicario, Wytske Fokkens, Emmanuel Prokopakis, Brecht Steelant
Summary: The study compared the effects of fluticasone furoate and mometasone furoate on epithelial barrier function, finding that both drugs similarly restored epithelial integrity by increasing expression of TJ proteins. Both drugs had beneficial effects on mucosal permeability, eosinophilic infiltration, and cytokine levels in a mouse model of allergic asthma.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Immunology
Erminia Ridolo, Alessandro Barone, Francesca Nicoletta, Giovanni Paoletti, Enrico Heffler, Luca Malvezzi, Giorgio Walter Canonica
Summary: Allergic rhinitis (AR) is a common disease with a significant impact on quality of life and high management costs. The use of multiple drugs for symptom control in AR patients often leads to poor therapeutic adherence. However, the novel intranasal corticosteroid/antihistamine combination, GSP301, has shown promising efficacy and safety in providing rapid symptom relief and good tolerability.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Article
Health Care Sciences & Services
Senthilraj Retinasekharan, Norasnieda Md Shukri, Ahmad Filza Ismail, Baharudin Abdullah
Summary: A new questionnaire was developed and validated to assess the knowledge, attitude, and practice of allergic rhinitis patients using intranasal corticosteroids. The questionnaire consists of 3 domains with 12 items and has demonstrated validity and reliability, making it a useful tool to improve patient treatment by understanding compliance factors.
Article
Pharmacology & Pharmacy
Nayara Almeida Lage, Mayara Rodrigues Brandao de Paiva, Daniel Vitor Vasconcelos-Santos, Renes Resende Machado, Silvia Ligorio Fialho, Armando Silva-Cunha
Summary: The study investigated the anti-inflammatory activity of Mometasone furoate (MF) in ocular tissues. It was found that at appropriate doses, MF was non-toxic and could attenuate disease progression, improve clinical, morphological, and functional parameters. The levels of inflammatory markers were also significantly reduced. Therefore, MF should be further explored as a promising drug for the treatment of ocular inflammation.
Article
Pharmacology & Pharmacy
Prempreet Kaur Manjit Singh, Elang Kumaran Krishnan, Norhafiza Mat Lazim, Najib Majdi Yaacob, Baharudin Abdullah
Summary: The study found that medication adherence to intranasal corticosteroid spray among allergic rhinitis patients is associated with severe nasal symptoms, allergen sensitization, and elevated total serum IgE levels. Multiple medication use had no impact on adherence. Lack of symptoms was a significant barrier to adherence, highlighting the need to emphasize the benefits of using the prescribed dose and frequency of intranasal corticosteroid spray to patients with mild and moderate allergic rhinitis.
Article
Pediatrics
Yamei Zhang, Ping Wei, Bobei Chen, Xiaoyan Li, Xianyang Luo, Xianming Chen, Mingliang Xiang, Lan Li, Sijun Zhao, Xuping Xiao, Xinmin Yang, Jie Chen, Yong Fu, Shuifang Xiao, Haixia Liu, Lei Cheng, Hongbing Yao
Summary: This study demonstrates the favorable efficacy and safety of fluticasone furoate nasal spray in Chinese pediatric allergic rhinitis patients, supporting its clinical use in treating children, including younger children aged 2-6 years. This research not only fills the gap in efficacy and safety data for intranasal corticosteroids in very young patients worldwide, but also shows a beneficial risk/benefit profile at different dosage levels. Our findings will be of interest to a broad readership and contribute positively to discussions on allergic rhinitis treatment in children aged 2-6 years.
PEDIATRIC RESEARCH
(2021)
Article
Immunology
Hossein Kasiri, Nima Rouhani, Ebrahim Salehifar, Monireh Ghazaeian, Sahar Fallah
Summary: The study aimed to evaluate the usage of mometasone furoate nasal spray in patients with severe microsmia or anosmia induced by COVID-19. The combination of mometasone furoate nasal spray with olfactory training showed greater improvement in patients with severe chronic anosmia by COVID-19 compared to olfactory training alone.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Otorhinolaryngology
Xuan Yuan, Shaobing Xie, Hua Zhang, Junyi Zhang, Ruohao Fan, Weihong Jiang, Zhihai Xie
Summary: Dust mite subcutaneous immunotherapy (SCIT) showed similar efficacy and safety in monosensitized and polysensitized children. Monosensitized children derived more benefits after discontinuation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Zan Ding, Nana Yang, Xin Cui, De Zhou
Summary: The study demonstrates that Biyuan Tongqiao granules combined with mometasone furoate nasal spray can significantly improve symptoms in children with allergic rhinitis, performing better than single drug treatment.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Yufeng Zhang, Tao Huang, Zhongfang Xia
Summary: The combination of Biyuantongqiao granules and mometasone furoate nasal spray is effective in improving symptoms of allergic rhinitis in children. The treatment significantly reduces nasal symptoms, decreases inflammatory markers, and has a higher total effective rate compared to mometasone furoate nasal spray alone.
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2022)
Article
Nanoscience & Nanotechnology
Shuya Masuda, Saori Deguchi, Fumihiko Ogata, Joji Yoshitomi, Hiroko Otake, Kazutaka Kanai, Naohito Kawasaki, Noriaki Nagai
Summary: In this study, a 0.05% mometasone furoate (MF) nanocrystal dispersion was designed and found to enhance local absorption compared to traditional nasal MF formulations. The use of in situ gelling systems, however, attenuated the local absorption of the MF nanocrystals.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Health Care Sciences & Services
Paola Andrea Rivera
Summary: The clinical effectiveness of fluticasone furoate nasal spray (FFNS) versus placebo was assessed in children with perennial allergic rhinitis. The results showed that FFNS produced a statistically significant reduction in reflective total nasal symptoms scores (rTNSS) compared to placebo in long-term treatment studies, but the reduction did not reach the minimal clinically important difference. Safety outcomes with FFNS were similar to placebo. Overall, FFNS does not produce a meaningful clinical effect on nasal symptoms in children with perennial allergic rhinitis.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2023)
Article
Pharmacology & Pharmacy
S. Ulusoy, N. Bayar Muluk, G. K. Scadding, G. S. Passali, M. Dilber, P. Gevaert, D. Passali, A. S. Resuli, L. van Gerven, L. Kalogjera, E. Prokopakis, P. Rombaux, P. Hellings, C. Cingi
Summary: This paper reviews the intranasal trigeminal system and its associated reflexes, emphasizing their importance in human health and disease, particularly in rhinitis. The intranasal trigeminal system provides sensory perception and responds to chemical signals, supplying information about the nasal airway. The known reflexes within this system play a vital role in human physiology.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Otorhinolaryngology
Adrian Williamson, Erica H. Mcardle, Hussein Jaffal
Summary: This study aims to describe the findings on drug-induced sleep endoscopy (DISE) in infants with laryngomalacia (LM). The results showed that DISE can identify obstruction at the level of the tongue base and complement the assessment of LM severity.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Tanya Chen, Melissa Lee, Evelyn Constantin, Joshua Gurberg, Lily HP. Nguyen
Summary: In the last two decades, there has been a high prevalence of funding and potential conflicts of interest in HSAT publications. Higher quality studies have increased in the last five years, but there still exists a lack of disclosure regarding funding or COI. There is a positive correlation between level of evidence and industry funding.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Stephen I. Pelton, Saskia Hullegie, Amanda J. Leach, Paola Marchisio, Tal Marom, Vishakha Sabharwal, Nader Shaikh, Paula A. Tahtinen, Roderick P. Venekamp
Summary: This study aims to identify and synthesize key research advances in the preventative measures and medical and surgical treatment of uncomplicated otitis media (OM), as well as the impact of the COVID-19 pandemic on OM management. The study found that there have been important advances in OM management in recent years, such as the effectiveness of video discharge instructions in reducing symptoms for parents of children with acute otitis media (AOM) and the efficacy of levofloxacin solution for treating chronic suppurative otitis media.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Thomas L. Haupt, Earl H. Harley
Summary: This study analyzed head and neck injuries caused by BB guns among children under 18 treated in US emergency departments between 1993 and 2019. It found that younger children are at increased risk of hospital admission, and injuries to the eye and neck are strong predictors of hospitalization.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Guy Faibish, Daniel Kaplan, Ariela Knaanie, Sabri Elsaeid, Oren Ziv
Summary: This study compared postoperative complication rates in pediatric cochlear implant candidates with and without otitis media with effusion (OME), and found that ventilation tube insertion for OME increased the rates of acute mastoiditis and chronic suppurative otitis media without cholesteatoma (CSOMWC).
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Andrew T. Gabrielson, Julie Wei
Summary: A survey conducted among members of the American Society of Pediatric Otolaryngology (ASPO) found that pediatric otolaryngologists commonly experience work-related musculoskeletal pain and lack knowledge about surgical ergonomics.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Review
Otorhinolaryngology
Alisha R. Pershad, Emily C. Knox, Rahul K. Shah, Habib G. Zalzal
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Keerthana Rajanbabu, Sakthilakshmi Gunasekaran, Heramba Ganapathy Selvarajan
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)
Article
Otorhinolaryngology
Austin D. Schafer, Megan Mcnutt, Amy Fulmer, Tran Bourgeois, Charles A. Elmaraghy
Summary: This study compared the risk of recurrent epistaxis in children treated with silver nitrate or electrocautery. The findings showed that patients treated with silver nitrate had significantly higher risk of recurrence compared to those treated with electrocautery.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2024)