Article
Multidisciplinary Sciences
Kyeong-Mee Park, Namkwon Lee, Jaeyeon Kim, Hyun Sil Kim, Wonse Park
Summary: This study aimed to investigate the preventive effect of teriparatide (TPD) administration on medication-related osteonecrosis of the jaw (MRONJ) before tooth extraction. The results showed that TPD reduced the occurrence of MRONJ in rats treated with zoledronic acid.
SCIENTIFIC REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang
Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kang-Min Kim, Sehyang Kim, Hyun Hwang, Hey-Yun Kim, Dohyun Kim, Jung-Hyun Park, HyeRan Choo, Jin-Woo Kim
Summary: This case-control study examined the therapeutic effects of daily or weekly administration of teriparatide in the management of medication-related osteonecrosis of the jaw (MRONJ). The results showed that both daily and weekly injection groups had significantly faster healing compared to the control groups. Complete resolution of MRONJ was more likely in participants who received teriparatide injections.
Review
Endocrinology & Metabolism
L. dos Santos Ferreira, L. G. Abreu, C. B. Calderipe, M. D. Martins, L. F. Schuch, A. C. U. Vasconcelos
Summary: The study aimed to integrate data on the use of TPTD for MRONJ cases, finding that TPTD in combination with another therapy, especially antibiotic therapy, can be considered an effective protocol for MRONJ.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
C. G. J. Monteiro, E. M. Vieira, C. Emerick, R. S. Azevedo, V. A. B. Pascoal, N. Homsi, R. X. Lins
Summary: The study aimed to evaluate the preventive effect of ozonated oil on the development of MRONJ-like lesions at tooth extraction sites in rats receiving zoledronic acid treatment. While there was no statistically significant difference in the average area of vital and necrotic bone between the groups, ozonated oil appeared to reduce osteonecrosis development. Further research is needed to confirm these findings.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Junho Jung, Gyu-Jo Shim, Minah Kim, Youngjae Yoon, Jae-Eun Kim, Seong-Suk Jue, Bilal Al-Nawas, Yong-Dae Kwon
Summary: The study demonstrated that preoperative PTH administration significantly reduced the number of empty lacunae and increased the number of blood vessels, suggesting more viable bone tissue in this group. However, postoperative PTH administration showed no significant differences compared to controls. Therefore, preoperative PTH use may represent a better prophylactic regimen for preventing MRONJ.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Medicine, General & Internal
Yesel Kim, Jeong-Kui Ku
Summary: This study successfully established a MRONJ rat model on the calvaria, which mimicked the characteristics of MRONJ and can be used for developing treatments for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Guang Yang, Sonal Singh, Caitrin W. McDonough, Jatinder K. Lamba, Issam Hamadeh, L. Shannon Holliday, Danxin Wang, Joseph Katz, Peter A. Lakatos, Bernadett Balla, Janos P. Kosa, Gian Andrea Pelliccioni, Douglas K. Price, Sara L. Van Driest, William D. Figg, Taimour Langaee, Jan S. Moreb, Yan Gong
Summary: The study identified a lead SNP, rs2736308 on chromosome 8, associated with an increased risk of MRONJ in patients with cancer and osteoporosis. This SNP is linked to genes regulating bone mineral density, providing insights into the potential mechanism of MRONJ.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Dentistry, Oral Surgery & Medicine
M. Anabtawi, H. Tweedale, H. Mahmood
Summary: This review examines the role and efficacy of teriparatide in treating MRONJ, finding significant variations in treatment outcomes and weak evidence quality. While teriparatide may be effective in treating refractory MRONJ in osteoporotic patients, further larger-scale, long-term randomized clinical trials are needed to confirm its efficacy.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Pharmacology & Pharmacy
Kirti Chopra, Namrita Malhan
Summary: MRONJ is a painful and intractable disease of the jaw with no established effective treatment, however, teriparatide may play an important role in the treatment with good efficacy.
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Article
Cell Biology
Xin Chen, Weiwen Zhu, Rongyao Xu, Xin Shen, Yu Fu, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: This study revealed that long-term use of bisphosphonates such as Zoledronic Acid (ZA) may lead to Bisphosphonate-related Osteonecrosis of the Jaw (BRONJ) by inhibiting macrophage efferocytosis and promoting osteocytic apoptosis. Additionally, supplementing with geranylgeraniol (GGOH) can restore Rac1 homeostasis and rescue macrophage efferocytosis, potentially providing a new treatment approach for BRONJ.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Kota Morishita, Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Miho Sasaki, Yukinori Takagi, Misa Sumi, Masahiro Umeda
Summary: The study found that a drug holiday of 3 months for medication-related osteonecrosis of the jaw in osteoporosis patients receiving antiresorptive agents does not promote sequestra separation or improve treatment outcomes, and early surgical therapy is recommended.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
George Adrian Ciobanu, Adrian Camen, Mihaela Ionescu, Daniel Vlad, Cristina Maria Munteanu, Mircea Ionut Gheorghita, Cristian Virgil Lungulescu, Ionela Elisabeta Staicu, Elena Claudia Sin, Luminita Chivu, Razvan Mercut, Sanda Mihaela Popescu
Summary: This study aimed to establish the importance of risk factors in the development of MRONJ in cancer patients receiving zoledronic acid therapy. The analysis of 174 cancer patients revealed that treatment duration, chemotherapy, and hypertension were risk factors, while endocrine therapy and obesity were protective factors for MRONJ.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Koma Sanda, Yasunori Ayukawa, Noriyuki Yasunami, Naomi Adachi, Akihiro Furuhashi, Mikio Imai, Ken Matsunaka, Kiyoshi Koyano
Summary: The study found that injecting fluvastatin after tooth extraction can promote the healing of medication-related osteonecrosis of the jaw-like lesions, reducing the risk of necrotic bone formation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Chemistry, Medicinal
Jung Sun Kim, Jin Woo Kim, Jeong Yee, Sun Jong Kim, Jee Eun Chung, Hye Sun Gwak
Summary: This study aimed to investigate the relationship between PPARγ and PPARGC1A polymorphisms and the development of BRONJ in female osteoporosis patients undergoing bisphosphonate treatment. The results showed that PPARGC1A rs2946385 and rs10020457 polymorphisms were significantly associated with BRONJ. Patients with the combined genotypes of GG in both PPARγ rs1151999 and PPARGC1A rs2946385 had a higher risk of BRONJ. Old age (≥70 years) and long duration of bisphosphonate use (≥60 months) also increased the risk of BRONJ.
Article
Surgery
Cem Ungor, Kerem Turgut Atasoy, Fatih Taskesen, Cagasan Pirpir, Onur Yilmaz
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Editorial Material
Dentistry, Oral Surgery & Medicine
Esra Baltacioglu, Bora Bagis, Abdullah Arslan, Malike Aslan Kehribar, Pinar Yuva, Guven Aydin, Mumin Yilmaz, Figen Cizmeci Senel
JOURNAL OF ORAL IMPLANTOLOGY
(2015)
Article
Dentistry, Oral Surgery & Medicine
N. Y. Altintas, F. Taskesen, B. Bagis, E. Baltacioglu, B. Cezairli, F. C. Senel
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Subutay Han Altintas, Serdar Kilic, Nuray Yilmaz Altintas, Figen Cizmeci Senel
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Y. T. Korkmaz, S. Kayipmaz, F. C. Senel, K. T. Atasoy, Z. Gumrukcu
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2017)
Review
Health Care Sciences & Services
Elif Ozyurt, Keziban Avci, Figen Cizmeci Senel
Summary: In order to provide safe, high-quality, and standardized services in healthcare facilities, the involvement and collaboration of various stakeholders are essential. Trust and collaboration between stakeholders are crucial for designing and implementing the necessary measures to effectively monitor patient outcomes. Clinical leadership practices based on collaboration and mutual respect among healthcare providers play a key role in the successful implementation and evaluation of these measures, especially in today's world where patient safety and quality of care are major concerns.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2021)
Article
Health Care Sciences & Services
Demet Gokmen Kavak, Umut Beylik, Ayse Keles, Figen Cizmeci Senel
Summary: This study examined the social perception of the COVID-19 pandemic and evaluated the public's knowledge, opinions, and emotional condition regarding COVID-19. The results showed that there were differences in knowledge and perception of COVID-19 among different factors such as living in rural areas, low education level, and socioeconomic level. While almost all of the society recognized COVID-19 as a highly contagious disease, they had different perspectives on their risk of getting the disease. The majority of the society (90.2%) considered social distancing measures to be very effective in preventing the spread of the disease.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2022)
Article
Health Care Sciences & Services
Zuhal Cayirtepe, Figen Cizmeci Senel
Summary: Accreditation is documented and reported by external evaluation organizations, and there is a trend towards using digital technologies in surveys. The Covid-19 epidemic has forced external evaluation organizations to work remotely and adopt digital technology. The use of artificial intelligence technologies in surveys may be the next digital trend.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2022)
Review
Medicine, General & Internal
Aslihan Candevir, Cem Ungor, Figen Cizmeci Senel, Yesim Tasova
Summary: Face masks are essential devices for both healthcare and community settings, providing source control and personal protection, especially during epidemics and pandemics. Studies have shown the association between face mask use and decreased risk of viral infections, highlighting the importance of promoting medical face mask use along with other infection control measures.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Health Care Sciences & Services
Fulya Basmaci, Mehmet Ali Kilicarslan, Figen Cizmeci Senel
Summary: This article discusses the impact of Covid-19 on dental laboratories and the necessary precautions to prevent cross-infection, emphasizing the importance of dental laboratories as a potential source of infection and providing guidelines for safety measures.
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2021)
Article
Medicine, General & Internal
Demet Gokmen Kavak, Ayse Sibel Oksuz, Canan Cengiz, Ibrahim Halil Kayral, Figen Cizmeci Senel
TURKISH JOURNAL OF MEDICAL SCIENCES
(2020)
Article
Health Care Sciences & Services
Yeliz Kilinc, Sara Samur Erguven, Figen Cizmeci Senel, Serpil Karaoglanoglu
JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
(2020)
Article
Medicine, General & Internal
Ezher Hamza Dayisoylu, Alper Pampu, Figen Cizmeci Senel, Ercument Onder, Dogan Dolanmaz, Nuray Yilmaz Altintas, Mustafa Cihat Avunduk
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2016)
Article
Surgery
Ugur Gulsen, Ilham Mehdiyev, Cem Ungor, Mehmet Fatih Senturk, Ali Direnc Ulasan
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2015)
