Article
Medicine, Research & Experimental
Matthew Stewart, Brian Swendseid, Perry Hammond, Ishani Khatiwala, Juliana Sarwary, Tingting Zhan, Ryan Heffelfinger, Adam Luginbuhl, Larissa Sweeny, Mark K. Wax, Joseph M. Curry
Summary: The study explores the impact of intraoperative revision (IOR) on free tissue transfer (FTT) outcomes. Results show that both intraoperative and postoperative revisions are associated with increased failure rates compared to nonrevised flaps, with arterial revision having the highest failure rate. Revision of both vessels and postoperative revision after intraoperative revision are strongly predictive of failure, highlighting the importance of careful management in FTT procedures.
Article
Otorhinolaryngology
Kevin J. Contrera, Abbas M. Hassan, John W. Shuck, Michael Bobian, Austin Y. Ha, Edward I. Chang, Patrick B. Garvey, Margaret S. Roubaud, Z-Hye Lee, Mathew M. Hanasono, Neil D. Gross, Jeffrey N. Myers, Peirong Yu, Rene D. Largo
Summary: Lateral arm autologous tissue transfer is a safe and reliable method for head and neck reconstruction with low donor-site morbidity. Complications are associated with peripheral vascular disease, pharyngeal defects, and vein grafts.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Oncology
Theresa Tharakan, Gifty Marfowaa, Kenneth Akakpo, Ryan Jackson, Joseph Zenga, Sidharth V. Puram, Patrik Pipkorn
Summary: This study retrospectively analyzed the experience of two tertiary academic centers in using multiple simultaneous free flaps for complex head and neck defect reconstruction. The results showed that multiple simultaneous free flaps are a rare but reliable option for patients with defects involving multiple tissue types, functional areas, or large volumes.
Article
Medicine, General & Internal
Paulo-Roberto Cardoso Ferreira, Rita Isabel Pinheiro De Oliveira, Marta Dias Vaz, Carla Bentes, Horacio Costa
Summary: Head and neck free-flap microvascular surgeries are complex procedures, and proper anaesthesia plays a crucial role in the outcome. Our institution has found that using an opioid-free anaesthesia strategy can significantly reduce postoperative complications and length of hospital stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Mark Ooms, Behrus Puladi, Khosrow Siamak Houschyar, Marius Heitzer, Ashkan Rashad, Johannes Bickenbach, Frank Hoelzle, Ali Modabber
Summary: Smoking has some effect on the perfusion of microvascular free flaps, but it does not decrease the flap survival rate.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Edward I. I. Chang
Summary: This study retrospectively analyzed the experience of a single surgeon performing alternate soft-tissue flaps over a 10-year period. A total of 156 surgeries were performed in 155 patients. The study found that reconstructive microsurgeons may need to incorporate alternate donor sites into their armamentarium when the primary workhorse flaps are not suitable or available.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Otorhinolaryngology
Leila J. Mady, Seerat K. Poonia, Khalil Baddour, Vusala Snyder, Chareeni Kurukulasuriya, Ariel S. Frost, Steven B. Cannady, Steven B. Chinn, Tanya Fancy, Neal Futran, Matthew M. Hanasono, Carol M. Lewis, Brett A. Miles, Urjeet Patel, Jeremy D. Richmon, Mark K. Wax, Peirong Yu, Mario G. Solari, Shaum Sridharan
Summary: A set of standardized terms for common free flap complications were defined through clinical consensus surveys, promoting consistency and comparability in reporting.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, Research & Experimental
Aaron Domack, Morgan M. Sandelski, Syed Ali, Keith E. Blackwell, Marisa Buchakjian, Andres M. Bur, Steven B. Cannady, Carlos X. Castellanos, Yadranko Ducic, Tamer A. Ghanem, Andrew T. Huang, Ryan S. Jackson, Niels Kokot, Shawn Li, Patrik Pipkorn, Sidharth V. Puram, Rod Rezaee, Karthik Rajasekaran, Yelizaveta Shnayder, Uttam K. Sinha, Daniel Sukato, Neeraj Suresh, Akina Tamaki, Carissa M. Thomas, Eric J. Thorpe, Mark K. Wax, Sara Yang, Andrea Ziegler, Amy L. Pittman
Summary: COVID-19 infection does not increase the risk of free flap complications in patients undergoing head and neck free flap reconstruction. However, these patients are at increased risk of medical complications.
Article
Anesthesiology
David W. Healy, Benjamin H. Cloyd, Tracey Straker, Michael J. Brenner, Edward J. Damrose, Matthew E. Spector, Amit Saxena, Joshua H. Atkins, Radhamangalam J. Ramamurthi, Arpan Mehta, Michael F. Aziz, Davide Cattano, Adam I. Levine, Samuel A. Schechtman, Laura F. Cavallone, Basem B. Abdelmalak
Summary: The perioperative care for adult patients undergoing free tissue transfer during head and neck surgical reconstruction lacks consistency. An expert group was formed to develop consensus statements through literature review and discussions to improve and standardize care. Key consensus statements focused on preoperative assessment, airway management, monitoring, fluid management, and other important aspects of care.
ANESTHESIA AND ANALGESIA
(2021)
Review
Otorhinolaryngology
Joshua A. Bloom, Christopher Homsy
Summary: Abdominal-based free flaps, though not commonly used in head and neck reconstruction, serve as great alternatives to traditional workhorse flaps. This review article aims to expand the toolbox of head and neck surgeons by introducing major abdominal-based free tissue transfers for reconstruction.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2021)
Article
Oncology
Cyrus J. Kerawala, Francesco Riva, Vinidh Paleri
Summary: This study evaluated the outcomes of early feeding on patients undergoing free flap reconstruction of oral defects and found that early feeding is not associated with increased incidence of post-operative complications but can reduce hospital stay.
Article
Otorhinolaryngology
Cassandre Lambert, Gwenaelle Creff, Vincent Mazoue, Paul Coudert, Olivier De Crouy Chanel, Franck Jegoux
Summary: This study aimed to identify risk factors for post-operative complications in micro-anastomosed osteomyocutaneous free flaps (MOFF) and analyze their long-term consequences. The results showed that alcohol consumption was an independent risk factor for surgical complications in MOFF, while patients with a history of chemotherapy, radiotherapy, or who were over 70 years of age were at a higher risk of postoperative medical complications.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Meghan M. Crippen, Rohan S. Ganti, Vivian Xu, Brian Swendseid, Diana L. Tzeng, Joseph Curry
Summary: This study found that patients with a history of VTE may have a higher risk of complications in head and neck free flap surgery, particularly increased risks of postoperative thrombosis and reoperation. Therefore, this risk should be considered in preoperative assessment and postoperative monitoring.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Steffen Schoepper, Ralf Smeets, Martin Gosau, Henning Hanken
Summary: The study aims to prove that intraoperative fluorescence-angiography using indocyanine-green (ICGFA) can predict perfusion-associated complications following microvascular reconstruction. The analysis of flow parameters shows a significant correlation between the ratio of maximum and minimum intensity (F-max/min) and the occurrence of complications.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Surgery
Daniel Boczar, Ricardo Rodriguez Colon, Lavinia Anzai, David A. Daar, Bachar F. Chaya, Jorge Trilles, Jamie P. Levine, Adam S. Jacobson
Summary: In microvascular free flap for head and neck reconstruction, there is no significant difference in postoperative complications and venous congestion between flaps with 1 and 2 venous anastomoses.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Review
Chemistry, Multidisciplinary
Sabrina C. Shen, Eesha Khare, Nicolas A. Lee, Michael K. Saad, David L. Kaplan, Markus J. Buehler
Summary: Engineered materials are important for modern technology but often contribute to ecological deterioration. Next-generation materials can address sustainability goals by providing alternatives to fossil fuel-based materials and reducing extraction processes and solid waste. Challenges include investigating and designing new feedstocks, which are mechanically weak and difficult to standardize. This review outlines a framework for examining sustainability in material systems and discusses the role of computational tools in discovering novel sustainable materials, with a focus on bioinspired and biobased materials.
Article
Materials Science, Multidisciplinary
Markus J. Buehler
Summary: We propose a deep learning method for predicting high-resolution stress fields from material microstructures using a novel class of progressive attention-based transformer diffusion models. The model is trained on a small dataset of input microstructures and corresponding atomic-level Von Mises stress fields obtained from molecular dynamics simulations, and demonstrates excellent accuracy in predicting results. Computational experiments show that the model can accurately predict distinct fracture scenarios, even when trained on a small dataset featuring samples of multiple cracks. Comparison with molecular dynamics simulations confirms the model's high fidelity in all cases, highlighting the exciting potential of progressive transformer diffusion models in the physical sciences for producing high-resolution field images.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Zhenze Yang, Yu-Chuan Hsu, Markus J. Buehler
Summary: We present a method of generating new protein designs through a generative adversarial neural network. The mechanical properties of the generated designs are evaluated using simulations and a neural network is developed to predict mechanical properties directly from the molecular architecture. The study provides insights into tailored nanomechanical properties and the nanomechanical responses of molecular structures. Manufactured samples of the designs are also reported using 3D printing.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Review
Chemistry, Physical
Dhriti Nepal, Saewon Kang, Katarina M. Adstedt, Krishan Kanhaiya, Michael R. Bockstaller, L. Catherine Brinson, Markus J. Buehler, Peter Coveney, Kaushik Dayal, Jaafar A. El-Awady, Luke C. Henderson, David L. Kaplan, Sinan Keten, Nicholas A. Kotov, George C. Schatz, Silvia Vignolini, Fritz Vollrath, Yusu Wang, Boris Yakobson, Vladimir V. Tsukruk, Hendrik Heinz
Summary: This Review discusses recent advancements in bioinspired nanocomposite design, focusing on the role of hierarchical structuring at different length scales in creating multifunctional, lightweight, and robust structural materials. By manipulating the architecture, interphases, and confinement, dynamic and synergistic responses have been achieved. The study highlights the significance of hierarchical structures across multiple length scales for achieving multifunctionality and robustness.
Article
Materials Science, Multidisciplinary
Markus J. Buehler
Summary: In this study, a computational approach for analyzing and designing multiscale architected materials is presented. The challenge lies in effectively modeling complex multi-level material structures for hierarchical design approaches. The authors propose an integrated deep neural network architecture that learns coarse-grained representations of complex microstructure data and solves forward and inverse problems through an attention-based diffusion model. The application of the method in the analysis and design of highly porous metamaterials is demonstrated, and the mechanical behavior is validated using molecular dynamics simulations.
MODELLING AND SIMULATION IN MATERIALS SCIENCE AND ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Eesha Khare, Xiangjun Peng, Zaira Martin-Moldes, Guy M. Genin, David L. Kaplan, Markus J. Buehler
Summary: Model verification is critical for scientific accountability, transparency, and learning. In this study, a model verification approach was applied to a molecular dynamics simulation, successfully replicating the key findings of the original model and gaining new insights. Improvements in model validation processes, particularly through enhanced documentation methods, were discussed. This protocol for model verification can be further applied to validate other simulations.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Materials Science, Biomaterials
Mario Milazzo, Vincent Fitzpatrick, Crystal E. Owens, Igor M. Carraretto, Gareth H. McKinley, David L. Kaplan, Markus J. Buehler
Summary: This study investigates the rheology, printability, and prosthetic mechanical properties of HA and HA-silk protein composites, highlighting the roles of composition and water content. The inclusion of silk improves the quality of printed items by reducing underextrusion and slumping. A printing map is constructed to guide the manufacturing of HA-based inks for biomedical applications requiring sub-millimetric features.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Bo Ni, David L. Kaplan, Markus J. Buehler
Summary: We present two generative deep-learning models capable of predicting amino acid sequences and 3D protein structures based on secondary structure design objectives. Both models are robust to imperfect inputs and have the capacity for de novo design, enabling the discovery of novel protein sequences not found in natural mechanisms or systems. The residue-level secondary structure design model demonstrates higher accuracy and more diverse sequences. These findings highlight untapped opportunities for protein design beyond known proteins. Our models, trained on a dataset extracted from experimentally known 3D protein structures using an attention-based diffusion model, have potential applications in the generative design of various biological or engineering systems. Further research could explore additional conditioning and other functional properties of the generated proteins beyond structural objectives.
Article
Computer Science, Artificial Intelligence
Markus J. Buehler
Summary: Taking inspiration from nature, humans have used the design approach of materials for centuries. This paper introduces the AttentionCrossTranslation model, which computationally discovers reversible relationships among patterns in different domains. The model is validated with known translation problems and then used to map musical data to protein sequences. The generated protein structures are validated using molecular dynamics and the music scores are turned into audible sound.
Article
Materials Science, Multidisciplinary
Sofia E. Arevalo, Markus J. Buehler
Summary: Biological systems provide inspiration and knowledge for scientists in various fields, as their material architectures often exhibit complex structures and functional interactions. By utilizing molecular-based multiscale modeling, machine learning, and artificial intelligence, along with experimental approaches, researchers can analyze, predict, and design materials with improved properties. This article explores materiomic graph-based modeling frameworks for materials-focused studies in a biological context, and provides an overview of methods applicable to bottom-up manufacturing.
Article
Materials Science, Multidisciplinary
Andrew J. Lew, Cayla A. Stifler, Astrid Cantamessa, Alexandra Tits, Davide Ruffoni, Pupa U. P. A. Gilbert, Markus J. Buehler
Summary: Bioinspired structures created by human engineering offer exciting possibilities for material configurations, but attaining desired properties is still challenging. This study examines the structure-property relationship by focusing on tooth enamel, the hardest biological tissue in humans. The use of artificial intelligence models enables rapid and non-destructive characterization of properties, and a deep image regression neural network is trained as a surrogate model. This model improves spatial resolution and sensitivity compared to experimental hardness maps, allowing for guided materials design.
Article
Chemistry, Physical
Eesha Khare, Jaden Luo, Markus J. Buehler
Summary: Several biological organisms use metal-coordination bonds to create remarkable materials, such as the jaw of the marine worm Nereis virens, which achieves impressive hardness without mineralization. This study investigates the role of metal ions, specifically zinc ions, in the structure and mechanical properties of the Nvjp-1 protein. The initial distribution of metal ions affects the protein's structure, while tensile strength is influenced by hydrogen bond content and uniform distribution of metal ions, providing insights for the development of hardened biomaterials and modeling proteins with significant metal ion content.
Article
Chemistry, Multidisciplinary
Eesha Khare, Darshdeep S. Grewal, Markus J. Buehler
Summary: Dynamic noncovalent interactions play a crucial role in the structure and function of biological proteins and have been explored in bioinspired materials. Metal-coordination bonds offer tunability and can control the properties of synthetic materials. However, understanding the exact contribution of these bonds towards mechanical strength and the effect of geometric arrangements is lacking. In this study, we engineer the cooperative rupture of metal-coordination bonds to enhance the rupture strength of metal-coordinated peptide dimers, and we provide quantitative insights into the cooperativity and intrinsic strength limit of these bonds. This work aims to advance the molecular design principles for metal-coordinated materials.
Article
Chemistry, Multidisciplinary
Wei Lu, David L. Kaplan, Markus J. Buehler
Summary: This study proposes a custom generative language model to design novel spider silk protein sequences with complex combinations of target mechanical properties. The model is fine-tuned on major ampullate spidroin (MaSp) sequences and enables the creation of silk sequences with unique combinations of properties. The study provides insights into the mechanistic roles of sequence patterns in achieving key mechanical properties and has implications for expanding the silkome dataset and synthetic silk design and optimization.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Markus J. Buehler
Summary: We introduce a flexible multi-modal mechanics language model, MeLM, that can solve various nonlinear forward and inverse problems in different fields, such as bio-inspired design, nanotube mechanics, and protein unfolding. MeLM effectively represents large-scale systems and performs well in complex mechanics design problems, offering potential for materials discovery and analysis.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
