Article
Chemistry, Multidisciplinary
In-Oh Choi, Ji-Su Oh, Sang-Joun Yu, Byung-Ock Kim, Won-Pyo Lee
Summary: The study evaluated the efficacy of using three-dimensional preformed titanium mesh for non-contained horizontal defects in guided bone regeneration, showing significant hard tissue gain rates in all three groups, with better results observed in patients using cross-linked collagen membranes in combination with the titanium mesh.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Francesca Delucchi, Enrico Pozzetti, Francesco Bagnasco, Paolo Pesce, Domenico Baldi, Francesco Pera, Nicolo Di Tullio, Paolo Pera, Maria Menini
Summary: The study found that DAE surfaces reduce peri-implant bone loss compared to machined surfaces, with a significant impact in the first year post implant insertion. However, in the long term, this surface treatment did not significantly affect soft tissue and bone maintenance.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Francesca Delucchi, Camilla Canepa, Luigi Canullo, Paolo Pesce, Gaetano Isola, Maria Menini
Summary: The aim of this systematic review is to summarize current knowledge on the use of biomarkers extracted from peri-implant crevicular fluid (PICF) as predictors of peri-implant bone loss (BL). A total of 158 entries were initially found, and after a full-text review and assessment of eligibility criteria, nine articles were selected. According to the review, several inflammatory biomarkers harvested from PICF seem to be correlated with peri-implant bone loss and may aid in diagnosing peri-implantitis early. MiRNA expression has shown predictive potential for peri-implant bone loss and may be useful for preventive and therapeutic purposes in implant dentistry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Waad Kheder, Amal Bouzid, Thenmozhi Venkatachalam, Iman M. Talaat, Noha Mousaad Elemam, Tom Kalathil Raju, Soumya Sheela, Manju Nidagodu Jayakumar, Azzam A. Maghazachi, Abdul Rani Samsudin, Rifat Hamoudi
Summary: This study analyzed the gene expression in peri-implant gingival tissues of patients with failed, successful, or no implants. The results showed that titanium particles modulate lymphocyte and macrophage polarization in peri-implant tissues, which may contribute to implant failure. The presence of titanium particles and infiltration of immune cells, particularly lymphocytes and macrophages, were confirmed in the failed implant samples. In vitro validation also demonstrated increased expression of IL-1 beta, IL-8, and IL-18 by macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lena Freitag, Thomas Spinell, Annika Kroger, Gregor Wuerfl, Michael Lauseker, Reinhard Hickel, Moritz Kebschull
Summary: This study aims to systematically review the impact of titanium particles on oral-related cells by examining changes in molecular signatures. Through a systematic search, 12 eligible publications were identified, and a significant overlap of gene expression in oral-related cells exposed to titanium particles was found in four studies. Changes in immune/inflammatory and stress response processes, as well as toll-like receptor and mitogen-activated protein kinase signaling pathways, were associated with titanium exposure in transcriptome and proteome studies. However, the findings regarding epigenetic changes caused by titanium were inconsistent.
Review
Medicine, Research & Experimental
Carlos Henrique Alves, Karolayne Larissa Russi, Natalia Conceicao Rocha, Fabio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello
Summary: In recent decades, there have been significant advances in ortho-aesthetic-functional rehabilitation with the introduction of implantology. However, there is still a percentage of failures in implantology surgeries, mainly due to infections caused by bacterial proliferation, fungi presence, and biofilm formation, leading to peri-implantitis. Various studies have been conducted to explore the interaction between the host-oral microbiome and the development of peri-implantitis. Peri-implantitis is associated with a diversity of bacterial species, with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia being identified in higher proportions of peri-implantitis samples. In addition, the injury of peri-implant tissue triggers an inflammatory response mediated by the activation of innate immune cells, such as macrophages, dendritic cells, mast cells, and neutrophils. Activation of the host immune system may disrupt the balance of oral microbiota, leading to dysbiosis and the production of various substances that contribute to implant loss.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lorenzo Marini, Cristiano Tomasi, Rodolfo Gianserra, Filippo Graziani, Luca Landi, Mauro Merli, Luigi Nibali, Mario Roccuzzo, Nicola M. Sforza, Maurizio S. Tonetti, Federico Deli, Piero Papi, Bianca Di Murro, Mariana A. Rojas, Andrea Pilloni
Summary: The purpose of this study was to evaluate the reliability and accuracy of assigning case definitions to dental implants according to the 2018 classification. The study found that the reliability and accuracy of the case definitions were mostly moderate.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
J. Martinez-Amargant, B. de Tapia, A. Pascual, J. Takamoli, C. Esquinas, J. Nart, C. Valles
Summary: This study aimed to determine the association between tobacco and peri-implant diseases and investigate patient- and implant-related variables associated with peri-implant diseases. Data from 117 patients treated with implant-supported restorations were analyzed, and the study found that smoke intensity was associated with an increased risk of peri-implant diseases.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Karin Apaza-Bedoya, Maria Elisa Galarraga-Vinueza, Bruna Barbosa Correa, Frank Schwarz, Marco Aurelio Bianchini, Cesar Augusto Magalhaes Benfatti
Summary: This study assessed the prevalence and risk indicators of peri-implant diseases, and associated specific clinical characteristics with these diseases. In the medium term, peri-implant diseases were correlated with factors inherent to the patient's conditions, presurgical treatment plan, and hygiene maintenance care.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Na Zhou, Haohao Huang, Hui Liu, Qiang Li, Guangwen Yang, Yu Zhang, Meng Ding, Heng Dong, Yongbin Mou
Summary: Analysis showed significant differences in bacterial structures between NH and PM implant groups, with higher relative abundance of Actinomyces and Streptococcus in NH samples. Genera Fusobacterium and Prevotella were identified as potential biomarkers for peri-implant mucositis. Moreover, gram-negative anaerobic bacteria, including Porphyromonas and Prevotella, were more prevalent in samples from patients with periodontitis history, indicating higher risk for peri-implant mucositis.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Chemistry, Physical
Hugo Robertson Sant'Anna, Marcio Zaffalon Casati, Mounir Colares Mussi, Fabiano Ribeiro Cirano, Suzana Peres Pimentel, Fernanda Vieira Ribeiro, Monica Grazieli Correa
Summary: This study found that the use of implants with modified macrogeometry can improve biomechanical retention and positively modulate important bone markers in the peri-implant bone tissue under diabetic conditions.
Review
Dentistry, Oral Surgery & Medicine
Andrea Roccuzzo, Jean-Claude Imber, Giovanni Edoardo Salvi, Mario Roccuzzo
Summary: Peri-implantitis is a common disease characterized by inflammation in the tissues around dental implants, leading to bone loss. Nonideal conditions in implant therapy, such as poor planning and insufficient periodontal therapy, may contribute to its progression. There is a good level of evidence for certain factors, while more research is needed to identify others and their long-term impact on peri-implantitis.
PERIODONTOLOGY 2000
(2023)
Article
Chemistry, Multidisciplinary
M. H. R. Borges, B. E. Nagay, R. C. Costa, C. M. Sacramento, K. G. Ruiz, R. Landers, J. J. J. P. van den Beucken, C. A. Fortulan, E. C. Rangel, N. C. da Cruz, V. A. R. Barao
Summary: This study proposes a two-step technique using plasma electrolytic oxidation (PEO) to improve the adhesiveness and mechanical properties of polypyrrole (PPy) films on implants. The results showed that PEO-treated titanium surfaces successfully achieved highly adherent PPy films with improved biocompatibility and corrosion resistance.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Polymer Science
Maria Baus-Dominguez, Serafin Maza-Solano, Celia Vazquez-Pachon, Marta Flores-Cerero, Daniel Torres-Lagares, Maria-Angeles Serrera-Figallo, Laura Macias-Garcia
Summary: This study aims to analyze the histological behavior of peri-implant soft tissues in three different restorative materials. The results show that the reinforced composite has a greater number of keratinized epithelial cells, indicating greater surface roughness and inflammatory response. The hybrid ceramic is the best material for rehabilitation, as it exhibits a better cellular response.
Article
Biochemistry & Molecular Biology
Morena Petrini, Tania Vanessa Pierfelice, Emira D'Amico, Natalia Di Pietro, Assunta Pandolfi, Camillo D'Arcangelo, Francesco De Angelis, Domitilla Mandatori, Valeria Schiavone, Adriano Piattelli, Giovanna Iezzi
Summary: Current research on dental implants has focused on the influence of surface roughness on osseointegration rate, while studies on developing surfaces to improve interaction with peri-implant soft tissues are lacking. This study showed that implant discs with Ti-S surfaces promoted adhesion and proliferation of gingival fibroblasts in vitro, suggesting their potential for in vivo applications. Further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Marina Carpano, Marina Perona, Carla Rodriguez, Susana Nievas, Maria Olivera, Gustavo A. Santa Cruz, Daniel Brandizzi, Romulo Cabrini, Mario Pisarev, Guillermo Juan Juvenal, Maria Alejandra Dagrosa
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2015)
Article
Chemistry, Inorganic & Nuclear
A. Portu, G. Saint Martin, D. Brandizzi, O. A. Bernaola, R. L. Cabrini
APPLIED RADIATION AND ISOTOPES
(2011)
Letter
Cell Biology
Maria Luisa Paparella, Daniel Brandizzi, Eduardo Santini-Araujo, Romulo Luis Cabrini
Article
Cell Biology
Maria Luisa Paparella, Liliana Graciela Olvi, Daniel Brandizzi, Alicia Keszler, Eduardo Santini-Araujo, Romulo Luis Cabrini
Article
Engineering, Biomedical
Daniel G. Olmedo, Deborah R. Tasat, Pablo Evelson, Raul Rebagliatti, Maria B. Guglielmotti, Romulo L. Cabrini
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2011)
Article
Engineering, Biomedical
Marcos E. Bruno, Deborah R. Tasat, Emilio Ramos, Maria L. Paparella, Pablo Evelson, Raul Jimenez Rebagliati, Romulo L. Cabrini, Maria B. Guglielmotti, Daniel G. Olmedo
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2014)
Article
Dentistry, Oral Surgery & Medicine
Daniel G. Olmedo, Maria L. Paparella, Martin Spielberg, Daniel Brandizzi, Maria B. Guglielmotti, Romulo L. Cabrini
JOURNAL OF PERIODONTOLOGY
(2012)
Article
Dentistry, Oral Surgery & Medicine
Daniel G. Olmedo, Gabriela Nalli, Sergio Verdu, Maria L. Paparella, Romulo L. Cabrini
JOURNAL OF PERIODONTOLOGY
(2013)
Article
Dentistry, Oral Surgery & Medicine
Maria Luisa Paparella, Mariela Gisele Domingo, Sebastian Ariel Puia, Elisabeth Jacobi-Gresser, Daniel Gustavo Olmedo
Summary: This descriptive histopathological study reviewed 68 cases of peri-implant tissue pathologies associated with titanium dental implants at the School of Dentistry, University of Buenos Aires from 1990 to 2018. A significant number of cases showed the presence of metallic particles, predominantly containing aluminum, titanium, iron, and nickel. The role of metallic particles in the development of these lesions remains unclear.
Article
Engineering, Biomedical
Maria Alvarez Echazu, Sandra Renou, Gisela Alvarez, Martin Desimone, Daniel Olmedo
Summary: Bone is a hierarchical material that has inspired the design of biopolymer-derived biocomposites for tissue engineering. The study synthesized a collagen-silica-based biocomposite and analyzed its ultrastructure, biodegradability, swelling behavior, and biocompatibility. In an in vivo experimental model, the biocomposite showed good biocompatibility properties and stimulated new bone formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Engineering, Biomedical
Mariela Gisele Domingo, Melisa Kurtz, Guillermo Maglione, Maximiliano Martin, Fernando Brites, Deborah Ruth Tasat, Daniel Gustavo Olmedo
Summary: This study evaluated the biological response of lung, liver, and kidneys to acute exposure to titanium dioxide. The results showed increased titanium concentration in the plasma and target organs after one month of exposure. Histopathological analysis revealed the presence of particles, but no structural changes were observed. Oxidative metabolism in the lung, liver, and kidneys showed alterations, with decreased antioxidant enzyme activity in the liver. Determination of serum biochemical markers and analysis of oxidative metabolism were not early bioindicators of tissue damage.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Orlando Auciello, Sandra Renou, Karam Kang, Deborah Tasat, Daniel Olmedo
Summary: The tissue response and biocompatibility of UNCD-coated titanium micro-implants were evaluated in a murine model. The histological evaluation showed good tissue integration and no inflammatory response. Although the osseointegration percentage was similar between the UNCD-coated and control groups, the tribological properties of UNCD make it a superior implant coating material.
Article
Biochemistry & Molecular Biology
Maria Alvarez Echazu, Sandra J. Renou, Gisela S. Alvarez, Martin F. Desimone, Daniel G. Olmedo
Summary: In this study, a chitosan-silica-based biocomposite was synthesized and characterized for its physicochemical properties and biocompatibility. The results showed that the biocomposite had good biocompatibility and could act as a template for cellular interactions and extracellular matrix formation, promoting new bone tissue formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
