Article
Medicine, General & Internal
Mattias Ulmner, Rachael Sugars, Aron Naimi-Akbar, Nikolce Tudzarovski, Carina Kruger-Weiner, Bodil Lund
Summary: Research findings suggest that certain protein concentrations are significantly related to poor surgical outcomes, while others are not. Bilateral masticatory muscle palpation pain is associated with disc displacement and osteoarthritis diagnoses, which may lead to unfavorable surgical outcomes. The multivariate model indicates that chronic inflammatory arthritis and patient-reported TMJ disability might be related to an unfavorable outcome.
Article
Orthopedics
Mengying Jia, Yaoguang Lv, Yingjie Xu, Zhongcheng Gong
Summary: The study revealed the potential involvement of the NLRP3 inflammasome signaling pathway in condylar degeneration of temporomandibular joint osteoarthritis, and demonstrated that sodium hyaluronic acid can reduce certain inflammatory molecules to alleviate inflammation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Pharmacology & Pharmacy
M. R. Mohammed, S. A. Hamad, A. D. Al-Daeoody, A. A. Shehab, O. S. Ahmed
Summary: This study evaluated the effectiveness of dextrose prolotherapy in treating internal derangement of the temporomandibular joint. 20 patients with internal derangement were treated with injections of 12.5% dextrose. Significant improvements were seen in pain, mouth opening, clicking, and deviation at 2, 4, and 12 weeks post-treatment. Prolotherapy was found to be a safe and effective treatment for alleviating the symptoms of internal derangement of the temporomandibular joint.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Seyma Bayindir, Canay Yilmaz Asan, Ahmet Emin Demirbas, Didem Barlak Keti, Nukhet Kutuk
Summary: The aim of this study was to investigate the effect of various mediators in synovial fluid on the pathogenesis of temporomandibular disorders and to evaluate the relationship between clinical and radiological features of temporomandibular joint diseases. The results suggested that aggrecan and adipokines may be precursors of degenerative joint disease, and the presence of localized pain in the joint area may be an early sign of degenerative changes.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Article
Medicine, Research & Experimental
Laskarin Ana -Marija, Laskarin Gordana, Kehler Tatjana, Grzic Renata, Dulcic Niksa
Summary: Spondyloarthritis (SpA) is a group of autoinflammatory/autoimmune diseases affecting the spine and peripheral joints. Temporomandibular disorders (TMDs) are correlated with cervical spine involvement. Proinflammatory cytokines, such as IL-23, IL-17A, and TNF-alpha, play significant roles in the immunopathogenesis of SpA and inflammation-related TMDs. The concentration of salivary IL-23, IL-17A, or TNF-alpha may serve as potential diagnostic markers for internal derangement of temporomandibular joints (TMJs) in patients with SpA, helping to broaden therapeutic approaches for symptomatic TMJ disorders.
MEDICAL HYPOTHESES
(2023)
Article
Dentistry, Oral Surgery & Medicine
S. Priyadarshini, A. Gnanam, B. Sasikala, P. Elavenil, S. Raja Sethupathy Cheeman, R. Mrunalini, V. B. Krishna Kumar Raja
Summary: The study aimed to compare the efficacy of dextrose prolotherapy with occlusal splints in treating internal derangement of the temporomandibular joint. Results showed that prolotherapy was superior in providing long-term clinical relief, with reduction in pain and clicking along with improved mouth opening. Patients who received prolotherapy demonstrated improvement in pain, mouth opening, and clicking, with no significant difference in deviation observed after 1 year.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Multidisciplinary Sciences
Ayman F. Hegab, Hossam IAbd Al Hameed, Khaled Said Karam
Summary: This study aimed to establish a new classification system for TMJ internal derangement based on MRI and correlate it with clinical findings to develop a nonsurgical treatment protocol. The results showed significant improvement in mouth opening, pain scores, and joint sounds following treatment according to the new staging system.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mattias Ulmner, Rachael Sugars, Aron Naimi-Akbar, Per Alstergren, Bodil Lund
Summary: This study aimed to investigate the relationship between cytokine concentrations in synovial fluid and synovial tissue and analyze the correlation between clinical parameters reflecting local inflammation and cytokine concentrations. The results showed weak correlations between cytokine concentrations in synovial fluid and synovial tissue, except for IL-8. Synovial tissue seemed to better reflect inflammation, suggesting the need for further exploration of synovial tissue in TMJ pathology and inflammation research.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Cell Biology
Glauce C. Nascimento, Bruna B. De Paula, Raquel F. Gerlach, Christie R. A. Leite-Panissi
Summary: The study found short- and long-term changes in the expression of MMP-2 and -9 in limbic structures during temporomandibular inflammation-induced orofacial persistent pain, with increased gelatinolytic activity in certain structures. Glial activation may play a role in the production of gelatinases during persistent orofacial pain, suggesting that inhibition of MMPs could be a potential therapeutic target for TMD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Douglas F. Werkman, Louis G. Mercuri, Jonathan P. Troost, Sharon Aronovich
Summary: Most TMJ surgeons do not prefer to use TMJ discectomy for treating TMJ internal derangements, but in cases of disc perforation or persistent symptomatic disc displacement without reduction, discectomy is considered beneficial.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
D. F. Angelo, H. J. Cardoso, D. Sanz
Summary: Synovial entrapment in alloplastic TMJ replacement can be a potential complication postoperatively, with implications that are still relatively unpredictable and poorly understood.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Cell Biology
Ute Nazet, Laura Feulner, Dominique Muschter, Patrick Neubert, Valentin Schatz, Susanne Graessel, Jonathan Jantsch, Peter Proff, Agnes Schroeder, Christian Kirschneck
Summary: This study investigated the impact of mechanical stress on murine synovial fibroblasts (SFs) of temporomandibular origin in the development and progression of temporomandibular joint osteoarthritis (TMJ OA). It was found that prolonged advanced mechanical stress on SFs promoted PG-E2 protein secretion, while decreasing the deposition of extracellular matrix components such as collagen and hyaluronic acid.
Article
Dentistry, Oral Surgery & Medicine
X. Liu, Y. Yang, L. Chen, S. Tian, A. Abdelrehem, J. Feng, G. Fu, W. Chen, C. Ding, Y. Luo, D. Zou, C. Yang
Summary: This study provides the first proteome analysis of condylar absorption and postoperative new bone formation in patients with disc displacement without reduction. Integrated with clinical data, this analysis offers important insights into the proteomics of condylar modification at disc position.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Salvatore Sembronio, Luca Raccampo, Alessandro Tel, Michele Di Cosola, Stefania Troise, Giovanni Dell'Aversana Orabona, Massimo Robiony
Summary: We report the experience of our maxillo-facial surgery unit in the diagnostic and therapeutic role of arthroscopy for temporomandibular joint synovial chondromatosis (SC). Arthroscopic treatment was successful in 87.5% of the patients, and a classification proposal based on clinical, radiological, arthroscopical, and histopathological characteristics was developed. TMJ arthroscopy should be considered as the first line of treatment for SC.
Review
Health Care Sciences & Services
Florent Destruhaut, Antoine Dubuc, Aurelien Bos, Laurent Fabie, Philippe Pomar, Jean-Claude Combadazou, Antonin Hennequin, Sara Laurencin
Summary: Synovial chondromatosis is a non-cancerous tumor that can be diagnosed with CBCT and MRI. It can be caused by primary lesions or trauma, with non-specific clinical manifestations that can lead to misdiagnosis.