Article
Oncology
Jie Yu, Qiqi Fan, Lingling Li
Summary: MCM3AP-AS1 is upregulated in EC and predicts poor prognosis. It acts as a ceRNA of miR-126 to upregulate VEGF, thereby regulating cancer cell behaviors in EC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rasa Liutkeviciene, Justina Auzelyte, Vykintas Liutkevicius, Alvita Vilkeviciute, Greta Gedvilaite, Paulius Vaiciulis, Virgilijus Uloza
Summary: This study evaluated the relationship between two polymorphisms (rs7412 and rs429358) of the ApoE gene and the development of laryngeal squamous cell carcinoma (LSCC). The findings suggest that the ApoE epsilon 2/epsilon 4 and epsilon 3/epsilon 4 genotypes have a protective role in LSCC development, while the ApoE epsilon 3/epsilon 3 genotype may increase the risk of LSCC development.
Article
Medicine, Research & Experimental
Jizi Zhou, Ying Zhao, Ping An, Huanqiang Zhao, Xiaotian Li, Yu Xiong
Summary: This study reveals that circRNA hsa_circ_0002348 is significantly increased in preeclampsia placentas and correlates with the severity of clinical manifestations. It functions as an endogenous sponge for miR-126-3p to upregulate BAK1 expression, thereby regulating trophoblast proliferation and apoptosis. Hsa_circ_0002348 may serve as a potential therapeutic target for preeclampsia.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yan-Ping Guo, Zhi-Feng Wang, Na Li, Qian-Qian Lei, Qiong Cheng, Li-Gang Shi, Sheng-Li Zhou, Xin-Hua Wang, Yang Sun, Ling-Fei Kong
Summary: This study found that lncRNA HOTAIR regulates RCC angiogenesis through the miR-126/EGFL7 axis, providing a new perspective on the molecular pathways of angiogenesis in RCC development and potentially serving as therapeutic targets for RCC treatment.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Oncology
Thorben Fruendt, Linda Krause, Elaine Hussey, Bettina Steinbach, Daniel Koehler, Johann von Felden, Kornelius Schulze, Ansgar W. Lohse, Henning Wege, Heidi Schwarzenbach
Summary: Exosomes carrying small non-coding RNA, particularly miR-16, miR-146a, miR-192, and miR-221, appear to be promising diagnostic and prognostic markers for hepatocellular carcinoma (HCC) and liver cirrhosis patients. MiR-146a showed potential as a diagnostic marker for distinguishing HCC patients from liver cirrhosis patients, while miR-192 independently correlated with overall survival in HCC patients.
Article
Multidisciplinary Sciences
Hiroya Yamada, Koji Suzuki, Ryosuke Fujii, Miyuki Kawado, Shuji Hashimoto, Yoshiyuki Watanabe, Hiroyasu Iso, Yoshihisa Fujino, Kenji Wakai, Akiko Tamakoshi
Summary: This study found that high levels of circulating miR-21 and miR-29a were significantly associated with an increased risk of total death, cancer death, and CVD death, while individuals with low levels of circulating miR-126 were more likely to experience total death. This suggests that circulating miRNAs may serve as potential biomarkers for early detection of high-risk individuals.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Yu-Tsai Lin, Hung-Chen Wang, Ming-Hsien Tsai, Yan-Ye Su, Ming-Yu Yang, Chih-Yen Chien
Summary: Nasopharyngeal carcinoma (NPC) is a common type of head and neck cancer in Asia. This study found that angiotensin II receptor blockers (ARBs) may improve the survival rates of NPC patients by increasing 5-year overall survival and disease-specific survival rates. The anticancer effects of ARBs in NPC were attributed to inducing apoptosis, inhibiting cell proliferation, and suppressing angiogenesis through the PI3K/AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Joanna Janiszewska, Magdalena Bodnar, Julia Paczkowska, Adam Ustaszewski, Maciej J. Smialek, Lukasz Szylberg, Andrzej Marszalek, Katarzyna Kiwerska, Reidar Grenman, Krzysztof Szyfter, Malgorzata Wierzbicka, Maciej Giefing, Malgorzata Jarmuz-Szymczak
Summary: The study demonstrates that miR-1290 suppresses MAF expression in LSCC, revealing the underlying interaction between the two. Immunohistochemistry staining showed loss of nuclear MAF expression in 58% of LSCC samples. Through data analysis, it was determined that loss-of-function mutations, promoter region DNA methylation or CNV are not responsible for MAF loss in LSCC.
Article
Oncology
Diana Marzic, Blazen Marijic, Tamara Braut, Stefan Janik, Manuela Avirovic, Ita Hadzisejdic, Filip Tudor, Katarina Radobuljac, Miran Coklo, Boban M. Erovic
Summary: IMP3 expression is higher in malignant laryngeal lesions compared to dysplasia and benign lesions, serving as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression is associated with worse clinical outcomes in patients with squamous cell carcinoma of the larynx.
Article
Cell Biology
Ce Li, Wenming Li, Shengda Cao, Jianing Xu, Ye Qian, Xinliang Pan, Dapeng Lei, Dongmin Wei
Summary: This study confirmed the carcinogenic effect of circ_0058106 in promoting tumorigenesis, metastasis, invasion, and EMT process of HSCC cells by regulating the Wnt2b/β-catenin/c-Myc pathway through sponging miR-185-3p, suggesting circ_0058106 may be a new therapeutic target and prognostic marker for HSCC.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Christina Gobin, Samuel Inkabi, Chayil C. Lattimore, Tongjun Gu, James N. Menefee, Mayrangela Rodriguez, Heather Kates, Christopher Fields, Tengfei Bian, Natalie Silver, Chengguo Xing, Clayton Yates, Rolf Renne, Mingyi Xie, Kristianna M. Fredenburg
Summary: In this study, differential miRNA expression in laryngeal squamous cell carcinoma (LSCC) between Black and White patients was examined. MiR-9-5p was found to be significantly lower in Black LSCC patients. The study showed that increasing miR-9-5p inhibited migration, proliferation, and increased cisplatin sensitivity in Black LSCC cells, while reducing miR-9-5p had the opposite effect in White LSCC cells. These findings suggest a crucial role of miR-9-5p in LSCC tumorigenesis and chemoresistance.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Lin Liu, Qing Han, Jing Cai, Man Xiao, Da Huang, Jin Cao
Summary: This study demonstrated that decreased expression of miR-126 is associated with poor prognosis in patients with ovarian cancer. MiR-126 may serve as a potential independent biomarker for predicting recurrence in epithelial ovarian cancer patients.
Article
Cell Biology
Chang-Liang Wu, Ti-Dong Shan, Yue Han, Yan Kong, Yuan-Bo Li, Xin-Gang Peng, Liang Shang, Pei-Ge Wang, Le-Ping Li
Summary: LINC00665 is significantly upregulated in CRC, promoting proliferation and inhibiting apoptosis through the regulation of key proteins. This suggests that LINC00665 may be an important biomarker and therapeutic target for colorectal cancer.
Article
Biotechnology & Applied Microbiology
Qi Liu, Xin Xu, Wei Sun
Summary: circ_0003528 is overexpressed in hepatocellular carcinoma (HCC) and knockdown of circ_0003528 suppresses tumor aggressiveness and growth. miR-212-3p functions through interaction with circ_0003528 and XIAP. Knockdown of circ_0003528 may be a potential therapeutic strategy for HCC treatment.
