Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 45, Issue 2, Pages 575-580Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2462
Keywords
colorectal cancer; cancer stem cells; CD24; EMT
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology
- Third Comprehensive 10-year Strategy for Cancer Control, Ministry of Health, Labor and Welfare
- Kobayashi Cancer Research Foundation
- Princess Takamatsu Cancer Research Fund
- Senshin Medical Research Foundation
- National Institute of Biomedical Innovation, Japan
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Conventional cancer chemotherapy preferentially destroys non-stem cancer cells within a tumor, and a subpopulation of cancer stem cells (CSCs) is more resistant and survives, leading to relapses and metastasis. Howeve, recent studies suggest that CD24 and susceptibility to epithelial-mesenchymal transition (EMT) can serve as markers of CSCs. We report that CD24(+) cells are susceptible to induction of EMT, a phenotype important for cancer metastasis. We studied the responsiveness of CSC markers to TGF-beta, an effective EMT inducer. The data on CD24 demonstrated that CD24(+) cells are susceptible to EMT, a phenotype important for cancer metastasis in two colorectal cancer cell lines, the CaR-1 and CCK81. CD24(+) cells expressed Notch 1 in response to exposure to TGF-beta in culture and showed higher tumorigenic activity compared to controls. This evidence shows that CD24(+) cells are susceptible to EMT induction and to cancer progression and is indicative of the candidacy of CD24 as a therapeutic target in CSC.
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