Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 45, Issue 2, Pages 895-901Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2014.2480
Keywords
resveratrol; melanoma; survivin
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (Japan) [24700971, 24659348]
- Kato Memorial Bioscience Foundation (Japan)
- Joint Usage/Research Center (Joint Usage/Research Center for Science-Based Natural Medicine), Institute of Natural Medicine, University of Toyama
- Grants-in-Aid for Scientific Research [24659348, 24700971] Funding Source: KAKEN
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Although many chemotherapies have been developed for melanomas, successful therapy would be aided by the identification of intrinsic mechanisms that are crucial for melanoma survival. Here, we used resveratrol, a phytoalexin, as an anti-melanoma reagent. Applying resveratrol to various human and murine melanoma cell lines, we show that survivin is essential for melanoma survival in vitro and in vivo and is targeted by resveratrol. Furthermore, we identify the downregulation of survivin transcription by resveratrol through the suppression of beta-catenin and STAT3. In addition, overexpression of survivin protects melanoma cells from resveratrol-induced apoptosis. Collectively, these studies establish that targeting survivin could provide an opportunity to treat melanoma patients.
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