Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells

SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells

(2011) M. Lauricella et al.   BIOCHIMIE

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

(2011) Caroline MM van Geelen et al.   BMC CANCER

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

(2011) Masahiro Sonoshita et al.   CANCER CELL

Proteasome inhibitors sensitize glioma cells and glioma stem cells to TRAIL-induced apoptosis by PKCε-dependent downregulation of AKT and XIAP expressions

(2011) Sarit Kahana et al.   CELLULAR SIGNALLING

Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma

(2011) Feng Chen et al.   CELLULAR ONCOLOGY

γ-Secretase Inhibitor-I Enhances Radiosensitivity of Glioblastoma Cell Lines by Depleting CD133+ Tumor Cells

(2010) Jun Lin et al.   ARCHIVES OF MEDICAL RESEARCH

REVIEW: γ-Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State

(2010) Francesco Panza et al.   CNS Neuroscience & Therapeutics

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

(2010) Zhiwei Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

(2010) Jon C Aster et al.   JOURNAL OF PATHOLOGY

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

The Synthetic Cannabinoid WIN 55,212-2 Sensitizes Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis by Activating p8/CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)/Death Receptor 5 (DR5) Axis

(2010) O. Pellerito et al.   MOLECULAR PHARMACOLOGY

The Notch signaling pathway: Transcriptional regulation at Notch target genes

(2009) T. Borggrefe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The PKB/AKT Pathway in Cancer

(2009) Amancio Carnero   CURRENT PHARMACEUTICAL DESIGN

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Notch1 Signaling Sensitizes Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Hepatocellular Carcinoma Cells by Inhibiting Akt/Hdm2-mediated p53 Degradation and Up-regulating p53-dependent DR5 Expression

(2009) Chunmei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of the PI3K/Akt/mTOR Pathway: New Hope for Breast Cancer Patients

(2009) Sandra Ghayad et al.   Recent Patents on Anti-Cancer Drug Discovery

c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells

(2008) Travis W. Day et al.   BIOCHEMICAL PHARMACOLOGY

Apoptosis induced in HepG2 cells by the synthetic cannabinoid WIN: Involvement of the transcription factor PPARγ

(2008) Michela Giuliano et al.   BIOCHIMIE

Molecular Dependence of Estrogen Receptor-Negative Breast Cancer on a Notch-Survivin Signaling Axis

(2008) C. W. Lee et al.   CANCER RESEARCH

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Notch1 is an effector of Akt and hypoxia in melanoma development

(2008) Barbara Bedogni et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch tumor suppressor function

(2008) G P Dotto   ONCOGENE

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY