Journal
MODERN RHEUMATOLOGY
Volume 25, Issue 3, Pages 449-452Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14397595.2014.964823
Keywords
Chinese Han male population; Gout; IL-23R; rs7517847
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Funding
- National Science Foundation of China [81070686, 31371272, 81100621]
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Objectives. Gout is a polygenic auto-inflammatory disease, in which inflammation plays an important role in disease pathogenesis. The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune-related diseases. This study aimed to determine whether the IL-23R rs7517847 (G/T) polymorphism is associated with gout in a Chinese Han male population. Methods. We recruited 400 patients with gout and 582 gout-free controls. After obtaining blood samples for DNA extraction, genotyping of the rs7517847 polymorphism was performed by fluorescence-based quantitative PCR using TaqMan probes. An association analysis was carried out using the chi(2) test. A genotype-phenotype analysis was also conducted. Results. Both genotypic and allelic frequencies of rs7517847 differed significantly between gout patients and controls (chi(2) = 6.792, df = 2, P = 0.034 by genotype; chi(2) = 4.202, df = 1, P = 0.04 by allele). Conclusions. IL-23R may be associated with gout in a Chinese Han male population, although our findings should be confirmed using larger sample sizes and other independent populations.
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