Article
Rheumatology
Marco Di Battista, Andrea Delle Sedie, Chiara Romei, Laura Tavanti, Mattia Da Rio, Riccardo Morganti, Alessandra Della Rossa, Marta Mosca
Summary: This study assessed the changes in lung ultrasound (LUS) and high-resolution CT (HRCT) in SSc-ILD patients treated with NIN, and found that NIN treatment significantly reduced the number of B-lines and pleural line irregularities. Male gender, smoking habit, and baseline forced vital capacity <70% predicted were associated with worse LUS outcomes. A greater reduction in imaging abnormalities was observed in those who improved in functional and quality-of-life outcomes.
Article
Biochemistry & Molecular Biology
Tamas Nagy, Nora Melinda Toth, Erik Palmer, Lorinc Polivka, Balazs Csoma, Alexandra Nagy, Noemi Eszes, Krisztina Vincze, Eniko Barczi, Aniko Bohacs, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Gyorgy Nagy, Emese Kiss, Pal Maurovich-Horvat, Veronika Muller
Summary: This study aimed to assess predictors of functional decline in SSc-ILD patients and compare disease behavior to IPF patients. The study found that cough and pulmonary hypertension are significant prognostic factors for functional progression in SSc-ILD patients.
Article
Rheumatology
David Roofeh, Kevin K. Brown, Ella A. Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U. Wells, Ganesh Raghu, Christopher P. Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A. Johannson, Yannick Allanore, Eric L. Matteson, Leticia Kawano-Dourado, John D. Pauling, James R. Seibold, Elizabeth R. Volkmann, Simon L. F. Walsh, Chester Oddis, Eric S. White, Shaney L. Barratt, Elana J. Bernstein, Robyn T. Domsic, Paul F. Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C. Mathai, Vibeke Strand, Tracy J. Doyle, Virginia Steen, Donald F. Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D. Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna
Summary: This study aimed to establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). The results showed that using the proposed conceptual framework, international experts were able to achieve a consensus on classifying SSc-ILD patients along the dimensions of disease severity, risk of progression and progression over time.
Article
Rheumatology
Cosimo Bruni, Mariaelena Occhipinti, Michael Pienn, Gianna Camiciottoli, Maurizio Bartolucci, Silvia Laura Bosello, Christian Payer, Zoltan Balint, Anna Rita Larici, Alessandra Tottoli, Lorenzo Tofani, Enrico De Lorenzis, Gemma Lepri, Silvia Bellando-Randone, Amelia Spinella, Dilia Giuggioli, Francesco Masini, Giovanna Cuomo, Federico Lavorini, Stefano Colagrande, Horst Olschewski, Marco Matucci-Cerinic
Summary: Recent advancements have made it possible to quantitatively assess lung vascular and parenchymal changes in thoracic CT images using automated software tools. In this study, the researchers investigated the vessel parameters of patients with SSc and correlated them with interstitial lung disease (ILD) features. The results showed that the CT vessel parameters increased in parallel with ILD extent and functional impairment, suggesting that they may serve as a biomarker of SSc-ILD severity.
Article
Medicine, General & Internal
Barbara Ruaro, Elisa Baratella, Paola Confalonieri, Marco Confalonieri, Fabio Giuseppe Vassallo, Barbara Wade, Pietro Geri, Riccardo Pozzan, Gaetano Caforio, Cristina Marrocchio, Maria Assunta Cova, Francesco Salton
Summary: Imaging, especially high-resolution computed tomography (HRCT), plays a crucial role in the evaluation of systemic sclerosis-associated interstitial lung disease (SSc-ILD). Most SSc patients with ILD show a non-specific interstitial pneumonia pattern on HRCT, while recent studies suggest that lung ultrasound (LUS) may be a valuable tool in SSc diagnosis and follow-up.
Article
Medicine, Research & Experimental
Masataka Kuwana, Aiko Saito, Wataru Sakamoto, Christina Raabe, Kumiko Saito
Summary: This study estimated the incidence and prevalence rates of systemic sclerosis (SSc) and SSc-associated interstitial lung disease (SSc-ILD) in Japan using medical databases. The results showed that approximately 30% of SSc patients had ILD, and the utilization of immunomodulatory medications was low.
ADVANCES IN THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Nicoleta Dima, Ioana Bratoiu, Ciprian Rezus, Alexandra Maria Burlui, Damiana Costin, Luana Andreea Macovei, Elena Rezus
Summary: Interstitial lung disease (ILD) is a serious manifestation of connective tissue diseases (CTD) that requires thorough evaluation and treatment. The prevalence of ILD in systemic lupus erythematosus (SLE) is still debated, but it is crucial to exclude an overlap syndrome for an accurate diagnosis. Increasing the identification of SLE-associated ILD cases is important, and various treatment options are being proposed. Systemic sclerosis (SSc)-associated ILD is a leading cause of mortality and should be investigated in all SSc patients. Progress has been made in the treatment of ILD, with tyrosine kinases inhibitor Nintedanib showing promising results in reducing the progression rate compared to placebo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Nicholas Landini, Martina Orlandi, Cosimo Bruni, Edoardo Carlesi, Cosimo Nardi, Linda Calistri, Giovanni Morana, Sara Tomassetti, Stefano Colagrande, Marco Matucci-Cerinic
Summary: The extent and severity of ILD can predict mortality in SSc-ILD patients on CT, as well as densitometric analysis parameters, fibrotic extent, and reticulation extent. Extensive ILD is also associated with death, need for supplemental oxygen, or lung transplantation. Honeycombing extent is a predictor for respiratory mortality.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Junfei Zhou, Meihua Gao, Shuai Zhang, Xiangting Lu, Zhidan Lei, Tianming Cheng, Yajing Liu, Tianshu Chu, Lipu Shi
Summary: Non-selective JAKi tofacitinib has been shown to improve interstitial lung disease (ILD) in patients with systemic sclerosis (SSc), reducing serum lactate dehydrogenase (LDH) concentration and interleukin-6 levels, improving lung function, and alleviating pulmonary HRCT findings including ground-glass attenuation and irregular pleural thickening. Tofacitinib also helps in ameliorating skin sclerosis and reducing pulmonary fibrosis in SSc-ILD patients. Further studies are needed to confirm these findings and explore the efficacy in more detail.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Nagy, Erik Palmer, Lorinc Polivka, Noemi Eszes, Krisztina Vincze, Eniko Barczi, Aniko Bohacs, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Gyoergy Nagy, Emese Kiss, Pal Maurovich-Horvat, Veronika Mueller
Summary: This study evaluated the clinical characteristics and predictors of lung function changes in SSc-ILD patients treated in a real-world setting. The results showed that untreated patients had the most prominent functional decline, and a normal body mass index was associated with a significant risk of deterioration. The majority of patients improved or were stable during follow-up.
Article
Biochemistry & Molecular Biology
Caterina Oriana Aragona, Antonio Giovanni Versace, Carmelo Ioppolo, Daniela La Rosa, Rita Lauro, Maria Concetta Tringali, Simona Tomeo, Guido Ferlazzo, William Neal Roberts, Alessandra Bitto, Natasha Irrera, Gianluca Bagnato
Summary: This review discusses recent advancements in the treatment of systemic sclerosis-associated interstitial lung disease, including new molecular targets and approved drugs to slow disease progression. The focus is on personalized treatment strategies based on emerging pathogenic features of the disease.
Article
Health Care Sciences & Services
Chiara Pellicano, Marzia Miglionico, Laura Romaggioli, Amalia Colalillo, Lorenzo Vantaggio, Cecilia Napodano, Cinzia Calla, Francesca Gulli, Mariapaola Marino, Umberto Basile, Edoardo Rosato
Summary: This study found that SSc patients have increased levels of CH50 and serum C2 compared to healthy controls. These findings may be associated with disease severity and the severity of skin and lung fibrosis in SSc patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Hye Jin Jang, Ala Woo, Song Yee Kim, Seung Hyun Yong, Youngmok Park, Kyungsoo Chung, Su Hwan Lee, Ah Young Leem, Sang Hoon Lee, Eun Young Kim, Ji Ye Jung, Young Ae Kang, Young Sam Kim, Moo Suk Park
Summary: This study aimed to identify risk factors for mortality and compare the clinical characteristics of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). The study found that approximately 10% of SSc-ILD patients showed disease progression, and ILD was detected within less than five years from the first visit. Therefore, careful monitoring of symptoms and signs from an early stage and long-term surveillance are necessary.
ANNALS OF MEDICINE
(2023)
Article
Rheumatology
Sabrina Hoa, Murray Baron, Marie Hudson
Summary: This international survey reveals regional variations in SSc-ILD screening and significant heterogeneity among rheumatologists and respirologists in the treatment of subclinical SSc-ILD. High-quality research is needed to produce evidence-based guidelines and harmonize the approach to identification and treatment of subclinical SSc-ILD.
Review
Biochemistry & Molecular Biology
Joe E. Mouawad, Carol Feghali-Bostwick
Summary: Systemic sclerosis, also known as scleroderma, is an autoimmune disorder that affects the connective tissues and has a high mortality rate. Fibrosis, particularly in the lungs, is a hallmark of the disease and is currently the leading cause of death. Understanding the molecular mechanisms involved in lung fibrosis is essential for developing potential therapies to improve patient outcomes and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Cesar Ramos-Remus, Aldo Barajas-Ochoa, Andrea Ramirez-Gomez, Jose D. Castillo-Ortiz, Victor Brambila-Barba, Adewale O. Adebajo, Luis R. Espinoza, Francisco J. Aceves-Avila, Jorge M. Sanchez-Gonzalez, Nadia Boudersa, Samy Slimani, Aicha Ladjouze-Rezig, Monica P. Diaz, Karin I. Kirmayr, Cecilia A. Asnal, Luis J. Catoggio, Gustavo Citera, Gustavo C. Casado, Analia P. Alvarez, Cecilia N. Pisoni, Emilio Benavente, Adriana Lopez-Cabanillas, Roberto M. Baez, Bernardo A. Pons-Estel, Monica P. Sacnun, Javier A. Cavallasca, Raul H. Paniego, Susanna M. Proudman, Ranjeny Thomas, Gabor Major, David M. Mathers, Leslie Schrieber, Nazrul Islam, Syed A. Haq, Patrick H. Dessein, Carlos A. von Muhlen, Washington A. Bianchi, Geraldo da R. Castelar-Pinheiro, Daniel Feldman-Pollak, Waldenise Cossermelli, Karina R. Bonfiglioli, Rina D. Giorgi, Wendlassida J. Zabsonre-Tiendrebeogo, Lilia Olaru, Jacob Karsh, Irene H. Castro-Esparza, Carlos Fuentealba, Sergio Aguilera, Paula I. Burgos, Oscar Neira, Zhan-guo Li, Lai-Shan Tam, Mo Y. Mok, Yimy F. Medina, Andres E. Zuniga-Vera, Mario J. Moreno-Alvarez, Claudia Vera, Ivonne Quezada, Ivan M. Moreno, Wendy Calapaqui, Ghada El-Mardenly, M. Salah Salama, Gaafar Ragab, Kamel Gado, Tahsin Hadidi, Marjatta Leirisalo-Repo, Riitta Tuompo, Riitta Koivuniemi, Francis Berenbaum, Yannick Allanore, Arnaud Constantin, Frank Buttgereit, Hendrik Schulze-Koops, Myriam Liz, Dzifa Dey, Carlos B. Santiago-Pastelin, Hugo D. Alonzo-Borjas, Victor Cuellar-Cruz, Balebail G. Dharmanand, G. C. Yathish, Shashank M. Akerkar, Anand N. Malaviya, Arman Ahmadzadeh, Tomoko Hasunuma, Benard O. Owino, Cesar Pacheco-Tena, Aaron Frausto-Arenas, Adrian A. De la Madrid-Cernas, Roman Cardona-Cabrera, Juan D. Centeno-Valadez, Isaura M. Rodriguez-Torres, Binit Vaidya, Arun K. Gupta, Andrew A. Harrison, Rebecca Grainger, Henry M. Nwankwo, Andreas P. Diamantopoulos, Elisabeth Maeland, Emilio Besada, Luis Gorriz, Margarita Duarte, Sonia Cabrera-Villalba, Maria T. Romero-de Albrecht, Augusto Garcia-Poma, Maria I. Segami, Maria P. Ramos, Wilkerson Perez-Medina, Maria L. Dianongco, Juan J. Lichauco, Geraldine Z. Racaza, Sandra V. Navarra, Tito P. Torralba, Bernadette H. Manapat-Reyes, Ester G. Penserga, Mohammed Hammoudeh, Samar Al-Emadi, Anna G. Botchkova, Sabri H. AlSaeedi, Hani Almoallim, Hussein F. Al-Arfaj, Wei H. Koh, Ying Y. Leung, David A. Whitelaw, Bridget Hodkinson, Javier Garcia-Miguel, Juan C. Duro, Emilio Martin-Mola, Maria Ahijon-Lana, Jose L. Andreu, Axel Finckh, Deshire Alpizar-Rodriguez, Manathip Osiri, Nuntana Kasitanon, Worawit Louthrenoo, Ronald F. van Vollenhoven, Niek de Vries, Christiaan van Denderen, Martjin Gerritsen, Tim L. Jansen, Piet van Riel, Concepcion M. Nunez-Sotelo, Sol Villegas-Morales
CLINICAL RHEUMATOLOGY
(2017)
Article
Rheumatology
Suparaporn Wangkaew, Chate Sivasomboon, Wit Leungwatthananon, Nuntana Kasitanon, Worawit Louthrenoo
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Wanruchada Katchamart, Pongthorn Narongroeknawin, Parawee Chevaisrakul, Pornchai Dechanuwong, Ajanee Mahakkanukrauh, Nuntana Kasitanon, Rattapol Pakchotanon, Kittiwan Sumethkul, Parichat Ueareewongsa, Sittichai Ukritchon, Thitirat Bhurihirun, Kittikorn Duangkum, Porntip Intapiboon, Samanan Intongkam, Wimol Jangsombatsiri, Kanon Jatuworapruk, Naravadee Kositpesat, Pawinee Leungroongroj, Wiyanoot Lomarat, Chonachan Petcharat, Siriluck Sittivutworapant, Patcharawan Suebmee, Pongchirat Tantayakom, Worakan Tipsing, Paijit Asavatanabodee, Praveena Chiowchanwisawakit, Chingching Foocharoen, Ajchara Koolvisoot, Worawit Louthrenoo, Boonjing Siripaitoon, Kitti Totemchokchyakarn, Tasanee Kitumnuaypong
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Article
Rheumatology
Nuntana Kasitanon, Pornkamon Boripatkosol, Worawit Louthrenoo
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2018)
Article
Rheumatology
Worawit Louthrenoo, Nuntana Kasitanon, Wanruchada Katchamart, Duangkamol Aiewruengsurat, Parawee Chevaisrakul, Praveena Chiowchanwisawakit, Pornchai Dechanuwong, Punchong Hanvivadhanakul, Ajanee Mahakkanukrauh, Siriporn Manavathongchai, Chayawee Muangchan, Pongthorn Narongroeknawin, Veerapong Phumethum, Boonjing Siripaitoon, Anawat Suesuwan, Siraphop Suwannaroj, Parichat Uea-Areewongsa, Sittichai Ukritchon, Paijit Asavatanabodee, Ajchara Koolvisoot, Ratanavadee Nanagara, Kitti Totemchokchyakarn, Kanokrut Nuntirooj, Tasanee Kitumnuaypong
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2017)
Editorial Material
Rheumatology
Kanon Jatuworapruk, Thanate Kattipathanapong, Nuntana Kasitanon, Worawit Louthrenoo
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2017)
Article
Rheumatology
Philip J. Mease, Slawomir Jeka, Juan Jose Jaller, Tasanee Kitumnuaypong, Worawit Louthrenoo, Herman Mann, Galina Matsievskaia, Enrique R. Soriano, Bin Jia, Caihong Wang, Jing Nie, Elizabeth Hsia
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Rheumatology
Worawit Louthrenoo, Kanon Jatuworapruk, Panomkorn Lhakum, Nuttaya Pattamapaspong
RHEUMATOLOGY INTERNATIONAL
(2017)
Article
Orthopedics
Nuttaya Pattamapaspong, Withawat Vuthiwong, Thanat Kanthawang, Worawit Louthrenoo
SKELETAL RADIOLOGY
(2017)
Article
Rheumatology
Alexis Ogdie, William J. Taylor, Tuhina Neogi, Jaap Fransen, Tim L. Jansen, H. Ralph Schumacher, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Maxim Eliseev, Geraldine McCarthy, Lisa K. Stamp, Fernando Perez-Ruiz, Francisca Sivera, Hang-Korng Ea, Martijn Gerritsen, Giovanni Cagnotto, Lorenzo Cavagna, Chingtsai Lin, Yin-Yi Chou, Anne-Kathrin Tausche, Manuella Lima Gomes Ochtrop, Matthijs Janssen, Jiunn-Horng Chen, Ole Slot, Juris Lazovskis, Douglas White, Marco A. Cimmino, Till Uhlig, Nicola Dalbeth
ARTHRITIS & RHEUMATOLOGY
(2017)
Article
Rheumatology
Angelo L. Gaffo, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi-Hsing Chen, Ching-Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Hansel Hernandez-Llinas, Tuhina Neogi, Ana Beatriz Vargas-Santos, Geraldo da Rocha Castelar-Pinheiro, Rodrigo B. C. Amorim, Till Uhlig, Hilde B. Hammer, Maxim Eliseev, Fernando Perez-Ruiz, Lorenzo Cavagna, Geraldine M. McCarthy, Lisa K. Stamp, Martijn Gerritsen, Viktoria Fana, Francisca Sivera, William Taylor
ARTHRITIS & RHEUMATOLOGY
(2018)
Article
Rheumatology
William J. Taylor, Jaap Fransen, Nicola Dalbeth, Tuhina Neogi, H. Ralph Schumacher, Melanie Brown, Worawit Louthrenoo, Janitzia Vazquez-Mellado, Maxim Eliseev, Geraldine McCarthy, Lisa K. Stamp, Fernando Perez-Ruiz, Francisca Sivera, Hang-Korng Ea, Martijn Gerritsen, Carlo Scire, Lorenzo Cavagna, Chingtsai Lin, Yin-Yi Chou, Anne-Kathrin Tausche, Geraldo da Rocha Castelar-Pinheiro, Matthijs Janssen, Jiunn-Horng Chen, Ole Slot, Marco Cimmino, Till Uhlig, Tim L. Jansen
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Review
Immunology
Poramed Winichakoon, Wanitcha Chanloung, Teerapat Nantsupawat, Worawit Louthrenoo
Summary: This study reported a rare case of Adult-onset Still's disease (AOSD)-like syndrome as a complication of COVID-19 vaccination. A total of 11 cases, including the one in this report, developed AOSD-like syndrome after vaccination, with fever and joint pain being the main clinical findings. Treatment with non-steroidal anti-inflammatory drugs and high-dose corticosteroids showed good responses.
Article
Rheumatology
Usanee Damrongpipatkul, Kanokporn Oranratanachai, Nuntana Kasitanon, Salita Wuttiplakorn, Worawit Louthrenoo
CLINICAL RHEUMATOLOGY
(2018)
Article
Rheumatology
Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora, Yeong-Jian Wu, Laniyati Hamijoyo, Madelynn Chan, Sean O'Neill, Fiona Goldblatt, Mandana Nikpour, Eric Francis Morand
ARTHRITIS RESEARCH & THERAPY
(2017)