Article
Immunology
Kyle Jones, Sergio Ramirez-Perez, Sean Niu, Umesh Gangishetti, Hicham Drissi, Pallavi Bhattaram
Summary: The study demonstrates the role of SOX4 and RELA in the regulation of gene expression downstream of TNF signaling, particularly in the transformation of FLS in arthritis and inflammatory pathology.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Wenhui Zhao, Ting Lin, Ziyi Fang, Huilin Zhou, Yangguang Du, Hexu Han
Summary: This study found that NAT10 expression was significantly increased in hepatocellular carcinoma (HCC) tissues and was associated with worse prognosis in HCC patients. NAT10 overexpression promoted HCC cell proliferation and migration, potentially through the activation of the NF-KB signaling pathway. NAT10 also played a role in HCC drug resistance by promoting acetyl-NF-KB p65 (Lys310) formation.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Marina Kolesnichenko, Nadine Mikuda, Uta E. Hoepken, Eva Kaergel, Bora Uyar, Ahmet Bugra Tufan, Maja Milanovic, Wei Sun, Inge Krahn, Kolja Schleich, Linda Hoff, Michael Hinz, Michael Willenbrock, Sabine Jungmann, Altuna Akalin, Soyoung Lee, Ruth Schmidt-Ullrich, Clemens A. Schmitt, Claus Scheidereit
Summary: The study reveals that DNA double-strand breaks elicit two subsequent phases of NF-kappa B activation, with the first phase controlling anti-apoptotic gene expression and the second phase driving expression of senescence-associated genes.
Article
Pharmacology & Pharmacy
Lihua Zhang, Zhongliang Li, Changcheng Xing, Ning Gao, Rui Xu
Summary: This study found that HHcy synergistically aggravated arterial damage in hypertensive rats through immune/inflammatory response, while folate demonstrated anti-inflammatory properties and reversed the NF-kappa B p65/Rela/IL-6 levels induced by HHcy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wendy A. Goodman, Shrikanth C. Basavarajappa, Angela R. Liu, Franklin D. Staback Rodriguez, Tailor Mathes, Parameswaran Ramakrishnan
Summary: Studies have shown that Sam68 is an important inflammatory driver in experimental colitis, reducing the expression of proinflammatory genes and suggesting that targeting Sam68 may hold promise for treating UC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Junichi Nunomura, Rei Nakano, Atsuto Naruke, Yoko Suwabe, Masumi Nakano, Naoya Yachiku, Manami Kuji, Mana Sugimura, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama
Summary: IL-1 beta triggers the expression of MMP-3 in melanoma cells, which is involved in cell migration.
Article
Chemistry, Medicinal
Renny Amelia, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita
Summary: NF-kappaB activity is associated with peptic ulcer disease. Chitin extracted from blue swimming crab shells can alter the translocation of NF-kappaB p65 and reduce ethanol-induced gastric ulcer index.
Article
Cell Biology
Joseph W. Hawkins, Madeleine C. McNeill, Reza Ebrahimighaei, Harry H. Mellor, Andrew C. Newby, Mark Bond
Summary: cAMP inhibits NF-kB activity by increasing nuclear actin monomer levels, leading to immunosuppressive and anti-inflammatory effects.
Article
Immunology
Masashi Mizuno, Rei Nakano, Saki Nose, Moeka Matsumura, Yasuyuki Nii, Kentaro Kurogochi, Hiroshi Sugiya, Masami Uechi
Summary: In this study, it was found that interleukin 1 beta (IL-1 beta) induces the expression of interleukin 8 (IL-8) in canine cardiac fibroblasts through the activation of nuclear factor (NF)-kappa B p65.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Spyros Foutadakis, Eugenia Roupakia, Panagiotis Liakopoulos, Petros Kolovos, Evangelos Kolettas
Summary: Transcription Factors (TFs) are key regulators of gene expression, controlling aspects such as cell homeostasis, identity, and fate. NF-kappa B and E2F1 are important TFs involved in inflammation and cell cycle progression, respectively. This study compared their genomic binding profiles and found distinct preferences in the type of DNA elements they bind to. Additionally, NF-kappa B and E2F1 showed limited overlap in their binding sites and tended to bind to active chromatin even before stimulation. Furthermore, NF-kappa B was found to recruit E2F1 near pro-inflammatory genes following immune stimulation.
Article
Biochemistry & Molecular Biology
Jill E. Hunter, Amy E. Campbell, Jacqueline A. Butterworth, Helene Sellier, Nicola L. Hannaway, Saimir Luli, Achilleas Floudas, Niall S. Kenneth, Adam J. Moore, Philip J. Brownridge, Huw D. Thomas, Jonathan Coxhead, Leigh Taylor, Peter Leary, Megan S. R. Hasoon, Andrew M. Knight, Michelle D. Garrett, Ian Collins, Claire E. Eyers, Neil D. Perkins
Summary: DNA replication stress is a common feature of cancer cells, and ATR/CHK1 signaling pathway is an attractive target for anti-cancer therapies. This study reveals the critical role of RelA NF-xB subunit in MYC induced DNA replication stress, suggesting its potential as a therapeutic target.
BIOCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Tugba Soydas, Muge Sayitoglu, Elif Yaprak Sarac, Suzan Cinar, Seyhun Solakoglu, Tunc Tiryaki, Gonul Kanigur Sultuybek
Summary: The study found that metformin can not only inhibit apoptosis of human dermal fibroblasts during skin aging at high glucose concentrations, but also reverse the impact on NF-kB through regulating the expression of COL1A1 and COL3A1.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Immunology
Lauren W. Kaminsky, Rana Al-Sadi, Thomas Y. Ma
Summary: The intestinal epithelial tight junction (TJ) barrier plays a crucial role in intestinal diseases, especially inflammatory bowel diseases. The IL-1 beta-induced increase in intestinal TJ permeability is a key factor in the inflammatory process.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Benjamin Ehst, Zhiping Wang, Justin Leitenberger, Danielle McClanahan, Rachel De La Torre, Erika Sawka, Alex G. Ortega-Loayza, Jennifer Strunck, Teri Greiling, Eric Simpson, Yuangang Liu
Summary: IL-23 plays a crucial role in Th17 immunity and inflammatory responses, especially in diseases like psoriasis. While dendritic cells are considered the main source of IL-23 in psoriasis, there is controversy surrounding the expression of IL-23 in psoriatic keratinocytes. Research has shown that a combination of TNF alpha and IL-17A can induce IL-23 production in human keratinocytes, with enhanced effects in psoriatic keratinocytes and EGFR signaling.
Article
Oncology
Kazumasa Mori, Shigeki Haraguchi, Miki Hiori, Jun Shimada, Yoshihiro Ohmori
Article
Biochemistry & Molecular Biology
Hana Yamaguchi, Miki Hiroi, Yoshihiro Ohmori
Article
Pathology
Shreeram C. Nallar, Sudhakar Kalakonda, Peng Sun, Yoshihiro Ohmori, Miki Hiroi, Kazumasa Mori, Daniel J. Lindner, Dhananjaya V. Kalvakolanu
AMERICAN JOURNAL OF PATHOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Miki Hiroi, Kazumasa Mori, Yoshiichi Sakaeda, Jun Shimada, Yoshihiro Ohmori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Cell Biology
Soji Fukumoto, Miki Hiroi, Paramasari Dirgahayu, Kazutoyo Miura, Sayuri Tademoto, Hitoshi Otsuki, Yoshihiro Ohmori
CELLULAR IMMUNOLOGY
(2012)
Article
Immunology
Kohsaku Uetani, Miki Hiroi, Tadamichi Meguro, Hiroshi Ogawa, Toshinori Kamisako, Yoshihiro Ohmori, Serpil C. Erzurum
EUROPEAN JOURNAL OF IMMUNOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Miki Hiroi, Kazumasa Mori, Keisuke Sekine, Yoshiichi Sakaeda, Jun Shimada, Yoshihiro Ohmori
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Cell Biology
Shigeru Amano, Keisuke Sekine, Lynda F. Bonewald, Yoshihiro Ohmori
JOURNAL OF CELLULAR PHYSIOLOGY
(2009)
Article
Cell Biology
Miki Hiroi, Yoshiichi Sakaeda, Hana Yamaguchi, Yoshihiro Ohmori
MEDIATORS OF INFLAMMATION
(2013)
Article
Oncology
Harumi Inoue, Yuji Miyazaki, Kentaro Kikuchi, Noriaki Yoshida, Fumio Ide, Yoshihiro Ohmori, Akihito Tomomura, Hideaki Sakashita, Kaoru Kusama
Article
Oncology
Hana Yamaguchi, Miki Hiroi, Kazumasa Mori, Ryosuke Ushio, Ari Matsumoto, Nobuharu Yamamoto, Jun Shimada, Yoshihiro Ohmori
Summary: This study investigated the gene expression kinetics of chemokines/cytokines during oral cancer development in a mouse model using the carcinogen 4NQO. The results showed that both Th1- and Treg-associated chemokines were simultaneously expressed in premalignant lesions, suggesting the initiation of anti-tumor immune responses and immunosuppression in the early stages of OLP development. This study highlights the role of chemokines and cytokines in immune cell recruitment and activation during oral cancer progression.
Article
Biochemistry & Molecular Biology
Ryosuke Ushio, Miki Hiroi, Ari Matsumoto, Kazumasa Mori, Nobuharu Yamamoto, Yoshihiro Ohmori
Summary: The combined treatment of DNMTis, HMTis, and HDACis in epigenomic therapy effectively reduces the viability of oral squamous cell carcinoma cells by inducing apoptosis and cell cycle arrest in the S and G2/M phases.
Article
Oncology
Masakatsu Fukuda, Miki Hiroi, Seiji Suzuki, Yoshihiro Ohmori, Hideaki Sakashita
Article
Dentistry, Oral Surgery & Medicine
Reina Kuroshita, Shigeru Amano, Shoji Takahashi, Hiroshi Sakagami, Yoshihiro Ohmori, Shigeru Watanabe
PEDIATRIC DENTAL JOURNAL
(2010)