Review
Immunology
Sicheng Zhang, Zhen Duan, Fang Liu, Qingjie Wu, Xiwei Sun, Hailong Ma
Summary: Rheumatoid arthritis (RA) is an autoimmune disease that affects joint health. Exosomes, which are secreted vesicles, contain various substances and play a role in cellular communication. Recent studies have shown that exosomes derived from different cells can influence the biological functions of immune cells and joint cells, but the exact mechanisms are still unclear. This comprehensive review provides a scientific foundation for utilizing exosomes as diagnostic targets and therapeutic approaches in the context of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Yu Wu, Zhuwei Zhang, Xiaoou Sun, Jing Wang, Haitao Shen, Xue Sun, Zhong Wang
Summary: This study found that inhibition of SDF-1/CXCR4 complex formation can rescue the inflammatory response and alleviate neurobehavioral dysfunction after intracerebral hemorrhage (ICH). Pharmacological inhibition with AMD3100 reduced the upregulation of SDF-1/CXCR4 and decreased levels of TNF-alpha and IL-1 beta. These findings suggest that SDF-1/CXCR4 may serve as a therapeutic target for ICH.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell & Tissue Engineering
Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, Hui-Chen Chen, Chia-Hung Hsieh
Summary: The study revealed that CXCR7 promotes the osteogenic and chondrogenic differentiation of MSCs and MSC-mediated immunomodulation by regulating multiple signaling pathways and anti-inflammatory soluble factors. MSCs with enhanced CXCR7 function significantly improved arthritic symptoms in a collagen-induced arthritis model.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Irene Rosa, Maria Simonetta Faussone-Pellegrini, Eloisa Romano, Lidia Ibba-Manneschi, Marco Matucci-Cerinic, Mirko Manetti
Summary: Recent studies have found that Telocytes (TCs)/CD34(+) stromal cells are detectable in various organs throughout the human body, and their impairment in the synovium of patients with rheumatoid arthritis (RA) may have important pathophysiological implications. The distribution of TCs/CD34(+) stromal cells is significantly altered in chronic synovitis, particularly in RA synovial tissue, suggesting potential roles of TCs in regulating tissue homeostasis and structure.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Anatomy & Morphology
Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya
Summary: This study aimed to determine whether the yield of synovial fluid MSCs could predict the ultimate yield of primary MSCs from the synovium of patients with RA. The results showed a positive correlation between the number of synovial fluid cells and synovial cells, and the synovial fluid MSCs exhibited MSC-like characteristics and multi-differentiation potential. These findings reveal the feasibility of using synovial fluid MSC yield to predict the synovial MSC yield.
Review
Chemistry, Medicinal
Marwa M. Qadri
Summary: Rheumatoid arthritis, osteoarthritis, and gout are common joint diseases with unclear pathogenesis. CD44 and its variants play a key role in joint damage and inflammation, suggesting that targeting CD44 could be a promising treatment strategy. PRG4 is a mucinous glycoprotein involved in joint lubrication, and lack of PRG4 expression leads to chronic inflammation and fibrosis. This review summarizes the role of PRG4-CD44 signaling in controlling synovitis, synovial hypertrophy, and tissue fibrosis in DJDs.
Review
Immunology
Marie-Astrid Boutet, Gabriel Courties, Alessandra Nerviani, Benoit Le Goff, Florence Apparailly, Costantino Pitzalis, Frederic Blanchard
Summary: Macrophages play a critical role in the pathogenesis and treatment of rheumatoid arthritis, advancements in high-throughput technologies have expanded the understanding of synovial cell diversity and potential therapeutic targets.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
Masanori A. Murayama, Jun Shimizu, Chie Miyabe, Kazuo Yudo, Yoshishige Miyabe
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-alpha, play crucial roles in RA development. Biological therapies targeting these cytokines have revolutionized RA treatment, but non-responsiveness is still a challenge. This review focuses on the pathogenic roles of chemokines and their receptors in RA and discusses their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Fuyu Jin, Yaqian Li, Xuemin Gao, Xinyu Yang, Tian Li, Shupeng Liu, Zhongqiu Wei, Shifeng Li, Na Mao, Heliang Liu, Wenchen Cai, Hong Xu, Haibo Zhang
Summary: Exercise training has the potential to mitigate the progression of silicosis by suppressing the SRB/NLRP3 and TLR4 pathways. Macrophage-derived IL-17A plays a key role in silica-induced pulmonary inflammation and fibrosis. Exercise training effectively inhibits the IL-17A-CXCL5-CXCR2 axis in silicotic mice, reducing collagen deposition and preserving elastic fibers, ultimately slowing down pulmonary fibrosis advancement and improving lung function post silica exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka
Summary: PAD4 contributes to the production of citrullinated proteins as autoantigens in RA. This study showed that autocitrullinated PAD4 can recruit monocytes and induce inflammation in mouse joints. Higher levels of citrullinated PAD4 were found in the synovial fluid of RA patients compared to osteoarthritis patients.
SCIENTIFIC REPORTS
(2023)
Article
Medical Laboratory Technology
Chen Qian, Jie Chen, Xiaopeng Xu, Qingyang Liu, Minhong Gu, Sheng Lu, Hongxia Bai, Qiubo Wang, Mingyu Xue
Summary: Synovium and serum DUSP22 levels were significantly decreased in RA patients, correlated with joint pain, inflammation markers, and disease activity scores. Serum DUSP22 levels were lowest in RA patients, increased after treatment, and positively correlated with synovium DUSP22 levels in RA patients.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Immunology
Dmitry Rychkov, Jessica Neely, Tomiko Oskotsky, Steven Yu, Noah Perlmutter, Joanne Nititham, Alexander Carvidi, Melissa Krueger, Andrew Gross, Lindsey A. Criswell, Judith F. Ashouri, Marina Sirota
Summary: This study identified 13 biomarkers for rheumatoid arthritis diagnosis and monitoring disease activity, utilizing gene expression data from large samples. These biomarkers can track disease activity, distinguish between osteoarthritis and rheumatoid arthritis, and monitor treatment effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hisakata Yamada
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting systemic synovial tissues, leading to the destruction of multiple joints. The etiology is unknown, but T-cell-mediated autoimmunity has been thought to play critical roles, which is supported by experimental as well as clinical observations. Efforts have been made to elucidate the functions and antigen specificity of pathogenic autoreactive T cells, but the hypothesis that Th1 and Th17 cells are pathogenic T cells in RA joints is not fully supported.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Orthopedics
J. Li, H. Chen, D. Zhang, J. Xie, X. Zhou
Summary: Stromal cell-derived factor 1 (SDF-1), also known as CXCL12, plays a crucial role in cartilage development and diseases by affecting chondrocytes through binding to CXCR4. It is not only a subject of research in cartilage development mechanisms, but also a potential therapeutic target for osteoarthritis and rheumatoid arthritis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Qian-Yue Zhang, Xiao-Ping Ye, Zheng Zhou, Chen-Fang Zhu, Rui Li, Ya Fang, Rui-Jia Zhang, Lu Li, Wei Liu, Zheng Wang, Shi-Yang Song, Sang-Yu Lu, Shuang-Xia Zhao, Jian-Nan Lin, Huai-Dong Song
Summary: By using single-cell RNA sequencing, this study reveals the presence of three stromal cell subtypes in the thyroidal microenvironment of Hashimoto's Thyroiditis, which may contribute to the recruitment of inflammatory immune cells. The study provides a deeper insight into the cellular interactions that might prompt the pathogenesis of Hashimoto's Thyroiditis.
NATURE COMMUNICATIONS
(2022)
