Journal
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume 35, Issue 4, Pages 693-699Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo_00000381
Keywords
adhesion; migration; invasion; extracellular matrix; glycosphingolipid; prostate cancer
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Funding
- US National Institutes of Health [RR-16480]
- New Mexico Tech
- New Mexico Department of Veteran Services
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The most lethal aspect of cancer is the metastatic spread of primary tumors to distant sites. Any mechanism revealed is a target for therapy. In our previous studies, we reported that the invasive activity of the bone metastatic C4-2B prostate cancer cells could be ascribed to the reorganization of the alpha 2 beta 1 integrin receptor and the alpha 2 subunit-mediated association and activation of downstream signaling towards the activation of MMPs. In the present study, we demonstrate that expression of asialoGM1 in C4-2B cells correlates with cancer progression by influencing adhesion, migration and invasion, via reorganization of asialoGM1 and colocalization with integrin alpha 2 beta 1. These observations reveal an uncharacterized complex of asialoGM1 with the integrin alpha 2 beta 1 receptor promoting cancer metastatic potential through the previously identified integrin-mediated signaling pathway. The present findings promote further understanding of mechanisms by which glycosphingolipids modulate malignant properties and the results obtained here propose novel directions for future study.
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