Article
Nutrition & Dietetics
Marina Berbegal, Mario Tome-Fernandez, Miriam Sanchez-SanSegundo, Ana Zaragoza-Marti, Jose Antonio Hurtado-Sanchez
Summary: The study found that obese individuals performed poorer in short-term phonological memory and working memory, with weight, BMI, waist-hip ratio index, body fat, and visceral fat showing inverse correlations with memory function. Muscle mass was not a significant predictor of memory function, while higher systolic blood pressure was associated with worse memory function.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Shweta Mital, Hai V. Nguyen
Summary: The cost-effectiveness of antiobesity drugs for adolescents is still unknown, although the American Academy of Pediatrics has recommended their use.
Article
Public, Environmental & Occupational Health
Xi Yang, Kaushik Chattopadhyay, Richard Hubbard, Jia-Lin Li, Li Li, Yi Lin
Summary: A 36-month weight management programme in Ningbo, China showed that participants achieved significant initial weight loss at 3 months and maintained the weight loss during 33-month follow-ups. At 36 months, a certain percentage of participants achieved 5%, 10%, and 15% weight loss. The programme is suggested to benefit overweight and obese adults in reducing body weight and maintaining long-term weight loss.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Nutrition & Dietetics
Farah J. Alsharif, Yara A. Almuhtadi
Summary: With the global prevalence of obesity increasing dramatically, it has become a serious public health threat associated with comorbid conditions and psychological disorders. While lifestyle interventions and dietary adjustments may help with weight loss, maintaining these changes long-term can be challenging. Spices like turmeric, ginger, and pepper have shown promise in obesity management, with curcumin in particular gaining interest for its health benefits. Studies have shown potential favorable effects of curcumin supplementation on anthropometric indices, warranting further investigation for overweight or obese adults.
Review
Endocrinology & Metabolism
Cosimo Giannini, Concetta Mastromauro, Serena Scapaticci, Cristina Gentile, Francesco Chiarelli
Summary: Bile acids are important molecules involved in digestion and also act as key regulators of metabolism and inflammation. Recent studies have shown that bile acids play a crucial role in glucose, lipid, and energy metabolism. The close relationship between bile acids and metabolic disorders suggests their potential as therapeutic targets for metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Guotao Sun, Long Li, Xiaolin Zhang
Summary: This study systematically explores scientific co-operation, disciplinary interaction, hotspots and trends in the field of weight loss in overweight/obese children and adolescents, and provides valuable references for further research. The main contribution of this study is to reveal the overall picture of the research in this field with visual maps and detailed data, which can help researchers quickly understand the status of studies, seek collaboration, and grasp research hotspots and frontier trends.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Megan Rodgers, Alexandra L. Migdal, Tahereh Ghorbani Rodriguez, Zsu-Zsu Chen, Anjali K. Nath, Robert E. Gerszten, Natasha Kasid, Elena Toschi, Juliet Tripaldi, Brent Heineman, Minh Phan, Long Ngo, Eleftheria Maratos-Flier, Jody Dushay
Summary: In this study, long-term weight loss with exenatide treatment was similar to that achieved with a hypocaloric diet in a population of early high responders. Weight loss at 3 months of treatment predicted super responder status in both treatment groups, with individual variability observed in weight loss outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Hiba Jebeile, Natalie B. Lister, Louise A. Baur, Sarah P. Garnett, Susan J. Paxton
Summary: The intersection between adolescent obesity and eating disorder risk is concerning, with recognized risk factors such as body dissatisfaction, poor self-esteem, depression, and dieting behaviors being elevated in this population. Supervised weight management may reduce eating disorder risk, but some adolescents may develop or have undiagnosed eating disorders, necessitating a risk management approach in clinical practice. Future research is needed to identify specific eating disorder risk factors in adolescents with obesity.
Article
Medicine, General & Internal
Samira M. Almalki, Nasser M. Al-Daghri, Mariam Eid Al-Juhani, Hanan A. Alfawaz
Summary: Background: Obesity is a chronic and inflammatory disease resulting from interactions between genes and environmental factors. Probiotics have shown potential as a supplementation for reducing obesity. However, limited studies have been conducted on human subjects in this field. Therefore, this study aims to investigate the anti-obesity effect of probiotic supplementation.
Article
Infectious Diseases
Sri Riyati Sugiarto, Madhu Page-Sharp, Jocelyn J. Drinkwater, Wendy A. Davis, Sam Salman, Timothy M. E. Davis
Summary: This study investigated the pharmacokinetic properties of artemether, lumefantrine, and their active metabolites in individuals with different body weights. The results indicate that dose modification of artemether-lumefantrine is not necessary for overweight and obese patients with malaria.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Nutrition & Dietetics
Bruna Clemente Cota, Sarah Aparecida Vieira Ribeiro, Silvia Eloiza Priore, Leidjaira Lopes Juvanhol, Eliane Rodrigues de Faria, Franciane Rocha de Faria, Patricia Feliciano Pereira
Summary: The study found that adolescents with the MONW phenotype were positively associated with anthropometric and body composition parameters such as waist circumference, waist-to-height ratio, and android-to-gynoid fat ratio.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Maria Choleva, Eleni Matalliotaki, Sokratis Antoniou, Eirini Asimomyti, Archontoula Drouka, Maria Stefani, Mary Yannakoulia, Elizabeth Fragopoulou
Summary: The aim of this study was to evaluate metabolic and oxidative stress responses after the intake of grape pomace (GP) extract in normal and overweight healthy women. The results showed that GP extract reduced uric acid, thiobarbituric acid substance levels, and superoxide dismutase activity in normal-weight women, while increasing uric acid and reducing protein carbonyls levels in overweight/obese women.
Review
Nutrition & Dietetics
Shan Wu, Jiani Jin, Kai-Lun Hu, Yiqing Wu, Dan Zhang
Summary: This study aimed to evaluate the optimal intervention strategy to prevent gestational diabetes mellitus (GDM) and restrict gestational weight gain (GWG) among overweight/obese pregnant women. The results showed that PA and diet + PA interventions had a trend of preventing GDM, and interventions of diet, PA, and diet + PA were significant factors to restrict GWG. Overall, a combination of diet and physical activity intervention seemed to be the superior choice for both GDM prevention and excessive GWG.
Article
Medicine, General & Internal
Francesca Lim, Brandon K. Bellows, Sarah Xinhui Tan, Zainab Aziz, Jennifer A. Woo Baidal, Aaron S. Kelly, Chin Hur
Summary: This study evaluates the cost-effectiveness of pharmacotherapy for obese adolescents. The results suggest that top-dose phentermine and topiramate as adjunct to lifestyle counseling is a cost-effective option after 5 years. However, long-term clinical trials are needed to fully evaluate the outcomes of pharmacotherapy.
Article
Endocrinology & Metabolism
Anna Stahl-Pehe, Silvia Selinski, Christina Baechle, Katty Castillo, Karin Lange, Reinhard W. Holl, Joachim Rosenbauer
Summary: The aim of this study was to screen individuals aged 14 to 30 with early-onset type 1 diabetes for generalized anxiety disorder (GAD) and compare the characteristics of those who tested positive versus negative. The results showed that positive screening results were associated with impairments in various domains, highlighting the extensive effects of GAD symptoms on the daily lives of adolescents and young adults with diabetes. Diabetologists should be aware of these potential impacts.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Regina Prigge, John A. McKnight, Sarah H. Wild
Summary: The study aimed to update and expand on an international comparison of glycemic control in individuals with type 1 diabetes, utilizing data from various sources between 2016 and 2020. Findings showed significant variations in glycemic control among different age groups and data sources, with suboptimal control observed for most individuals with type 1 diabetes. Despite some improvements over time, there is still room for enhancement in glycemic control.
Article
Environmental Sciences
Stefanie Lanzinger, Hicran Altug, Tamara Schikowski, Semik Khodaverdi, Joachim Rosenbauer, Wolfgang Rathmann, Kirsten Praedicow, Eckhard Schoenau, Reinhard W. Holl
Summary: The study revealed that air pollution is associated with higher HbA1c levels and increased risk of severe hypoglycemia in individuals with type 1 diabetes.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
B. Hartmann, S. R. Tittel, M. Femerling, M. Pfeifer, S. Meyhoefer, K. Lange, S. Milek, L. Stemler, F. Best, R. W. Holl
Summary: This study aimed to assess changes in diabetes management during the COVID-19 lockdown for patients with type 1 or type 2 diabetes mellitus in Germany. The results showed that patients with both types of diabetes experienced only clinically insignificant changes in glucose control or body weight during the lockdown period, indicating that they were able to maintain metabolic control despite the restrictions.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Pediatrics
Susann Weihrauch-Bluher, Susanna Wiegand, Paul Weihe, Nicole Prinz, Daniel Weghuber, Georg Leipold, Almut Dannemann, Lara Bergjohann, Thomas Reinehr, Reinhard W. Holl
Summary: This study investigated the associations between BMI-SDS/WHtR and serum uric acid (sUA)/gamma-glutamyl-transferase (GGT) levels, as well as cardiometabolic risk markers in children with obesity, considering factors such as sex, pubertal development, and weight loss/type of patient care. The findings suggest that abdominal obesity may contribute to hyperuricemia and hepatic involvement in prepubertal children. Even moderate weight loss has beneficial effects on cardiometabolic risk profile and glucose homeostasis.
Article
Medicine, General & Internal
Nicole Prinz, Resthie R. R. Putri, Thomas Reinehr, Pernilla Danielsson, Daniel Weghuber, Mikael Norman, Niels Rochow, Claude Marcus, Reinhard W. Holl, Emilia Hagman
Summary: Background: Children with obesity have an increased risk of cardiometabolic risk factors, but not all children carry a similar risk. Perinatal factors, i.e., gestational age (GA) and birth weight for GA, may affect the risk for metabolic complications. However, there are conflicting data whether the association between birth size and cardiometabolic risk factors is independent among children with obesity. Moreover, differential effects of GA and birth weight for GA on cardiometabolic risk factors in pediatric obesity are still unexplored. We aimed to investigate the association between birth weight for GA and cardiometabolic risk factors in children and adolescents with overweight or obesity and to assess whether the association is modified by prematurity.
Article
Pediatrics
Julia M. M. Goeldel, Clemens Kamrath, Kirsten Minden, Susanna Wiegand, Stefanie Lanzinger, Claudia Sengler, Susann Weihrauch-Blueher, Reinhard W. W. Holl, Sascha R. R. Tittel, Petra Warschburger
Summary: This study investigates the access to healthcare for children and adolescents with three common chronic diseases (T1D, obesity, or JIA) during the COVID-19 pandemic in Germany. The results show that overall satisfaction with healthcare was high and the proportion of canceled appointments was relatively small. Only a few parents reported obstacles to health services during the pandemic. Therefore, it seems that access to healthcare was largely preserved for this population in Germany.
Article
Pediatrics
Petra Warschburger, Clemens Kamrath, Stefanie Lanzinger, Claudia Sengler, Susanna Wiegand, Julia M. Goeldel, Susann Weihrauch-Blueher, Reinhard W. Holl, Kirsten Minden
Summary: This study aims to analyze the multiple impacts on health care and psychosocial well-being on children and adolescents with chronic physical health conditions (CCs) and their parents during the COVID-19 pandemic.
Article
Endocrinology & Metabolism
Christian Denzer, Joachim Rosenbauer, Daniela Klose, Antje Koerner, Thomas Reinehr, Christina Baechle, Carmen Schroeder, Susanna W. Wiegand, Reinhard Holl, Nicole Prinz, DPV Initiative
Summary: The incidence of pediatric type 2 diabetes in Germany increased during the COVID-19 pandemic, with a significant increase observed in 2021. Adolescent boys were more affected, resulting in a reversal of the sex ratio of youth-onset T2D.
Review
Endocrinology & Metabolism
Clemens Kamrath, Alexander J. Eckert, Reinhard W. Holl, Joachim Rosenbauer
Summary: The COVID-19 pandemic has affected the incidence of type 1 diabetes and the frequency of diabetic ketoacidosis, but the exact relationships are unclear. It is also unknown whether these effects are temporary or have long-term relevance. Additionally, it is unclear whether the changes during the pandemic are due to direct effects of SARS-CoV-2 or changes in the patient's environment.
PEDIATRIC DIABETES
(2023)
Article
Endocrinology & Metabolism
Anna Stahl-Pehe, Christina Baechle, Kalman Bodis, Oana-Patricia Zaharia, Karin Lange, Reinhard Holl, Michael Roden, Joachim Rosenbauer
Summary: This study analyzed the impact of diabetes distress and depression on T1D patients and found that the age at which adults develop T1D is associated with the level of diabetes distress, but not with depression.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Endocrinology & Metabolism
Marie Auzanneau, Alexander J. Eckert, Andreas Fritsche, Martin Heni, Andrea Icks, Annabel S. Mueller-Stierlin, Ana Dugic, Alexander Risse, Stefanie Lanzinger, Reinhard W. Holl
Summary: The study analyzed the proportion of diabetes among hospitalized cases in Germany from 2015 to 2020. Using nationwide statistics, they identified diabetes cases based on ICD-10 codes and also included COVID-19 diagnoses for 2020. The results showed that the proportion of diabetes cases increased from 18.3% in 2015 to 18.5% in 2019, and further increased to 18.8% in 2020. The study highlights the higher prevalence of diabetes in hospital settings and its association with COVID-19. Rating: 8 out of 10.
ENDOCRINE CONNECTIONS
(2023)
Article
Cell Biology
Lara Lechner, Robert Opitz, Matt J. Silver, Philipp M. Krabusch, Andrew M. Prentice, Martha S. Field, Harald Stachelscheid, Elsa Leitao, Christopher Schroeder, Valeria Fernandez Vallone, Bernhard Horsthemke, Karl-Heinz Joeckel, Boerge Schmidt, Markus M. Noethen, Per Hoffmann, Stefan Herms, Patrick W. Kleyn, Matthias Megges, Ulrike Blume-Peytavi, Katja Weiss, Knut Mai, Oliver Blankenstein, Benedikt Obermayer, Susanna Wiegand, Peter Kuehnen
Summary: Increasing evidence suggests that epigenetic variants play a role in the development of obesity. The study identified POMC hypermethylation as a risk factor for obesity and found that it is not genetically determined. The researchers also established an embryonic stem cell model to investigate the early establishment of POMC methylation states.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Susann Weihrauch-Blueher, Oliver Huizinga, Christine Joisten, Juliane Pflanz, Gabriel Torbahn, Susanna Wiegand, Christina Holzapfel, Hans Hauner
Summary: A cross-sectional survey was conducted in Germany in April/May 2022 focusing on the impact of the COVID-19 pandemic on lifestyle and health behavior of children and adolescents. The results showed that children aged 10-12 years and those from low-income families were particularly affected, with negative changes in eating habits, physical activity, and media consumption. Urgent political action is needed to address the adverse consequences on childhood lifestyle and health.