Article
Food Science & Technology
Roman Cardona-Herrera, Elena Franco-Robles, Tannia Alexandra Quinones-Munoz, Cesar Ozuna
Summary: This study evaluated the relationship between the degree of hydrolysis of agave syrup (AS) and its functional properties, and investigated the impact of these properties on weight gain, blood biochemical parameters, and oxidative stress in mice. The results showed that as the degree of hydrolysis increased, the fructose concentration of AS increased, while the concentration of fructans, bioactive compounds, and antioxidant capacity decreased. Moreover, mice drinking AS50 solutions showed a significant decrease in weight gain, cholesterol, triglycerides, and oxidative stress compared to mice drinking AS88 and AS95 solutions.
Article
Nutrition & Dietetics
Desiree M. Sigala, Bettina Hieronimus, Valentina Medici, Vivien Lee, Marinelle Nunez, Andrew A. Bremer, Chad L. Cox, Candice A. Price, Yanet Benyam, Yasser Abdelhafez, John P. McGahan, Nancy L. Keim, Michael Goran, Giovanni Pacini, Andrea Tura, Claude B. Sirlin, Abhijit J. Chaudhari, Peter J. Havel, Kimber L. Stanhope
Summary: This study examined the dose-response effects of consuming high fructose corn syrup (HFCS)-sweetened beverages on hepatic lipid content and insulin sensitivity. The results showed that consuming HFCS-sweetened beverages was associated with an increase in hepatic lipid content and a decrease in insulin sensitivity. These findings strengthen the mechanistic evidence linking HFCS-sweetened beverage consumption to metabolic dysregulation, nonalcoholic fatty liver disease, and type 2 diabetes risk.
Article
Biochemistry & Molecular Biology
Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa
Summary: Obesity and metabolic syndrome increase the susceptibility to chronic kidney disease (CKD), potentially due to enhanced absorption and utilization of fructose. Pound mice with metabolic syndrome showed increased expression of fructose transporter and fructokinase, leading to enhanced fructose absorption. Administration of high fructose corn syrup (HFCS) rapidly induced CKD in pound mice, whereas pound mice lacking fructokinase were protected from CKD. Lowering added sugar intake may reduce the risk for CKD in subjects with metabolic syndrome.
Article
Food Science & Technology
Ta-Kang Huang, Min-Chieh Chuang, Yi Kung, Bo-Chuan Hsieh
Summary: The study developed a sensing approach using charge transfer resistance (RCT) and logarithmic impedance (Log Z) to differentiate pure honey, blended honey, and HFCS, with good resolution and reproducibility. The data acquisition time for obtaining RCT and Log Z were only 3 min and 4 s, suitable for routine rapid screening purpose.
Article
Public, Environmental & Occupational Health
S. C. Dumith, O. P. L. Martins, M. K. V. Moreira, R. G. Paulitsch, M. O. Simoes, L. P. Marmitt, P. E. A. Silva, M. P. Silva
Summary: This study aimed to describe the trends in diabetes mellitus (DM) prevalence in Brazil and analyze the association with the consumption of artificially sweetened beverages. The study used data from VIGITEL surveys (2006-2020) including adults from Brazilian state capitals. The results showed an increasing prevalence of DM over the years, with a four times greater annual percentage change in those who consumed diet/light/zero beverages. The study concludes that a significant reduction in the annual percentage change of DM could be observed if people stopped consuming diet/light soda/juice.
Article
Biochemistry & Molecular Biology
Hidemi Hattori, Yuma Hanai, Yuto Oshima, Hiroaki Kataoka, Nozomu Eto
Summary: Excessive consumption of HFCS drinks, such as soft drinks, without a proper diet, induces nonobese IGT due to insulin-secretion defect. This study found that excess HFCS-water intake did not lead to obesity, but impaired glucose tolerance (IGT) due to insulin-secretion defect. The intake of HFCS-water affected glucose and fructose metabolism by decreasing the expression of certain enzymes in the pancreas.
Article
Food Science & Technology
Milad Pero, Bahareh Borhani, Sadaf Kaffashi Parvian, Roghayeh Rashidi, Mehdi Jafari Asl
Summary: This study examines the substitution of sucrose with high fructose corn syrup in chocolate syrup and analyzes the physicochemical, rheological, and sensory properties of the samples. The results show that high fructose corn syrup can effectively replace sugar and has potential applications in chocolate syrup formulation.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Endocrinology & Metabolism
Joanne A. Harrold, Scott Hill, Cristina Radu, Paul Thomas, Paula Thorp, Charlotte A. Hardman, Paul Christiansen, Jason C. G. Halford
Summary: Non-nutritive sweetened beverages can be more effective in maintaining weight loss compared to water in a behavioral weight management program, but the difference is not clinically significant.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Joanne A. A. Harrold, Scott Hill, Cristina Radu, Paul Thomas, Paula Thorp, Charlotte A. A. Hardman, Paul Christiansen, Jason C. G. Halford
Summary: The objective of this study was to compare the weight loss effects of non-nutritive sweetened beverages and water after a 12-week behavioral weight-management program. The study found that both non-nutritive sweetened beverages and water were equally effective for weight loss during the program.
Review
Nutrition & Dietetics
Xiang Li, Yunqi Luan, Yuejin Li, Shili Ye, Guihui Wang, Xinlun Cai, Yucai Liang, Hamed Kord Varkaneh, Yunpeng Luan
Summary: The meta-analysis suggests that HFCS intake is associated with an increase in CRP levels compared to sucrose, while no significant differences were observed in other anthropometric and metabolic parameters between the two sweeteners.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Lingqi Wu, Huajing Fang, Kai Jing, Haolin Yu, Zhiwei Shan
Summary: In this study, a facile and versatile strategy has been proposed to synthesize high-performance electrochromic metal oxides using waste carbonated beverages as raw materials. By creating nanoscale pores and oxygen vacancies through a carbonization pre-step, the annealed thin film exhibits excellent electrochromic properties. This research provides a new approach for cost-effective electrochromic materials and multiscale optimization of superior metal oxides.
Article
Biochemical Research Methods
Marlies Diepeveen-de Bruin, Walid Maho, Marion E. C. Buso, Novita D. Naomi, Elske M. Brouwer-Brolsma, Edith J. M. Feskens, Michiel G. J. Balvers
Summary: In this study, an ultra-pressure liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to quantify glucose, sucrose, fructose, sucralose, saccharine, acesulfame, cyclamate, and steviol glucuronide in human urine. The method showed acceptable accuracy and precision for quantifying dietary sugars and sweeteners in human urine.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Review
Nutrition & Dietetics
Cherie Russell, Carley Grimes, Phillip Baker, Katherine Sievert, Mark A. Lawrence
Summary: Poor diets, including excessive added sugar consumption, contribute to the global burden of disease. Many nutrition policies have been implemented to reduce added sugar intake, potentially leading to the substitution of non-nutritive sweeteners (NNS) in foods and beverages. NNS are widely used to reduce energy and sugar content while maintaining palatability, but concerns remain over their potential substitution effects in ultra-processed foods. More research is needed to understand NNS consumption trends globally and their impact on dietary patterns.
NUTRITION RESEARCH REVIEWS
(2021)
Article
Food Science & Technology
Nasim Khorshidian, Mahdi Shadnoush, Maryam Zabihzadeh Khajavi, Sara Sohrabvandi, Mojtaba Yousefi, Amir M. Mortazavian
Summary: High-fructose syrups are commonly used in the food industry, but their intake may have direct relationships with adverse health effects such as obesity and the metabolic syndrome, attracting negative attention recently. Studies have suggested potential correlations between high fructose-rich diet and negative effects, but generalizing these findings to high fructose corn syrup (HFCS) is not certain due to using high concentrations of pure fructose in prior research. The advantages and possible disadvantages of HFCS application and consumption are currently challenging issues between nutritionists and food technologists.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Behavioral Sciences
Meenu Minhas, Cheryl L. Limebeer, Evan Strom, Linda A. Parker, Francesco Leri
Summary: The study suggests that dietary sugars may affect vulnerability to opioid abuse. The findings indicate that high fructose corn syrup may increase place preference induced by oxycodone, enhance its suppressant effect on locomotion, and attenuate its elevation in dopamine overflow in the NAc.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
