Article
Biology
Monika Ostap-Chec, Monika Opalek, Daniel Stec, Krzysztof Miler
Summary: Honeybee workers exhibit withdrawal symptoms, with increased ethanol consumption and mortality rates, after prolonged exposure to ethanol spiked food, but do not display an increased appetite for ethanol diluted in water. These findings suggest that workers can develop alcohol dependence and may be a valuable model for studying alcohol addiction in a natural setting.
Review
Psychiatry
Reza Moshfeghinia, Kimia Jazi, Shabnam Kabaranzadghadim, Mahdi Malekpour, Bahare Oji
Summary: Chronic abuse of zolpidem can lead to dependence, withdrawal symptoms, and abuse. High doses can cause extreme cravings and dependence, requiring medical management during the withdrawal process.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Pharmacology & Pharmacy
Hanis Mohammad Hazani, Isa Naina Mohamed, Mustapha Muzaimi, Wael Mohamed, Mohamad Fairuz Yahaya, Seong Lin Teoh, Rashidi Mohamed Pakri Mohamed, Mohd Fadzli Mohamad Isa, Sundus Mansoor Abdulrahman, Ravi Ramadah, Mohammad Rahim Kamaluddin, Jaya Kumar
Summary: Globally, millions of people suffer from substance use disorders, including the use of opioids and methamphetamine. Certain brain regions play important roles in addiction-related behavioral changes. Polydrug abuse has been associated with poorer treatment outcomes, drug-related deaths, and more severe psychopathologies. However, the pharmacological treatment efficacy for polydrug abuse is still unclear and experimental.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Casper J. H. Wolf, Harmen Beurmanjer, Boukje A. G. Dijkstra, Alexander C. Geerlings, Marcia Spoelder, Judith R. Homberg, Arnt F. A. Schellekens
Summary: This study examined the course of GHB withdrawal symptoms under pharmaceutical GHB tapering, finding that it does not significantly differ from withdrawal syndromes of other sedative drugs. There was no association between vital signs and withdrawal symptoms, and vitals were not suitable for monitoring withdrawal. Sex differences were observed in the severity and prevalence of specific withdrawal symptoms, highlighting the importance of personalized approaches in GHB detoxification.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
M. L. Eckard, S. G. Kinsey
Summary: Gabapentin may be effective in reducing cannabis withdrawal symptoms, particularly somatic and affective symptoms, but may act independently of endocrine stress activation.
Article
Biochemistry & Molecular Biology
Leisheng Shi, Yan Wang, Chong Li, Kunlin Zhang, Quansheng Du, Mei Zhao
Summary: AddictGene is a resource that integrates multidimensional data related to commonly abused substances, including gene expression, gene-gene interaction, gene-drug interaction, and epigenetic regulatory information. This database provides detailed information about differentially expressed genes, offering a valuable resource for studying the molecular mechanisms underlying addiction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Paul J. Fitzgerald
Summary: Previous studies have shown that alcohol intake interacts with dopamine, norepinephrine, and epinephrine signaling molecules. This study proposes the existence of a biosynthetic pathway that converts alcohol into these catecholamines in organisms. The study provides detailed instructions on how to test this hypothesis in mice using stable isotope-labeled ethanol. Confirmation of this hypothesis could have significant implications for neuroscience and our understanding of alcohol abuse.
Article
Health Care Sciences & Services
Hector Isaac Rocha-Gonzalez, Lidia Elizabeth De la Cruz-Alvarez, Ashuin Kammar-Garcia, Samuel Canizales-Quinteros, Juan Carlos Huerta-Cruz, Lina Marcela Barranco-Garduno, Juan Gerardo Reyes-Garcia
Summary: The study analyzed the impact of body weight loss in the first month of treatment with 30 mg phentermine and the development of tolerance to phentermine on its 6-month efficacy. It found that early development of tolerance to phentermine could decrease the effectiveness of weight loss over 6 months, while patients with greater weight loss in the first month had better weight loss outcomes at 6 months.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Psychiatry
Tuyen T. Le, Isabel Pazos Cordero, Muhammad Youshay Jawad, Jennifer Swainson, Joshua D. Di Vincenzo, Saja Jaberi, Lee Phan, Leanna M. W. Lui, Roger Ho, Joshua D. Rosenblat, Roger S. McIntyre
Summary: This scoping review examines the abuse liability of ketamine and its enantiomers. Preclinical studies suggest that (R,S)-ketamine and (S)-ketamine have a higher risk for abuse, while (R)-ketamine shows minimal abuse liability at doses relevant for antidepressant effects. Limited clinical studies indicate that ketamine administration in professionally controlled settings did not result in misuse, dependence, diversion, or gateway activity in patients with treatment-resistant depression (TRD).
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Surgery
Sukriti Mohan, Jamil S. Samaan, Agnes Premkumar, Kamran Samakar
Summary: Most current evidence suggests that abuse history is not associated with weight loss outcomes after bariatric surgery. The relationship between abuse history and postoperative psychiatric outcomes is inconclusive and further studies are needed. Abuse history should not preclude patients from undergoing bariatric surgery, but careful monitoring and appropriate treatment for psychological distress and comorbidities should be provided.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Gavin C. Jones, Christina A. Small, Dallin Z. Otteson, Caylor W. Hafen, Jacob T. Breinholt, Paul D. Flora, Matthew D. Burris, David W. Sant, Tysum R. Ruchti, Jordan T. Yorgason, Scott C. Steffensen, Kyle B. Bills
Summary: This study used a Wistar rat model to evaluate the effectiveness of whole-body vibration (WBV) as a preventative measure for the neuronal and behavioral effects of morphine withdrawal. The results showed that concurrent administration of WBV at 80 Hz with morphine significantly reduced adaptations in neuronal activity and dopamine release, as well as modulated the expression of δ-opioid receptors on cholinergic interneurons in the nucleus accumbens. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kathrin Jobski, Carsten Bantel, Falk Hoffmann
Summary: This study analyzed spontaneous reports of fentanyl-associated abuse, dependence, and withdrawal in European countries. It found that fentanyl is mainly used for non-cancer pain indications and often in transdermal formulations. Patients with musculoskeletal disorders had a higher prevalence of depression and prolonged hospitalizations.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Itzel G. Salazar-Valencia, Hugo Villamil-Ramirez, Francisco Barajas-Olmos, Martha Guevara-Cruz, Luis R. Macias-Kauffer, Humberto Garcia-Ortiz, Omar Hernandez-Vergara, David Alberto Diaz De Sandy-Galan, Paola Leon-Mimila, Federico Centeno-Cruz, Luis E. Gonzalez-Salazar, Rocio Guizar-Heredia, Edgar Pichardo-Ontiveros, Leonor Jacobo-Albavera, Rosalinda Posadas-Sanchez, Gilberto Vargas-Alarcon, Rafael Velazquez-Cruz, Ruth Gutierrez-Aguilar, Carlos Zerrweck, Hector Isaac Rocha-Gonzalez, Juan Gerardo Reyes-Garcia, Miriam Del C. Carrasco-Portugal, Francisco Javier Flores-Murrieta, Armando R. Tovar, Lorena Orozco, Teresa Villarreal-Molina, Samuel Canizales-Quinteros
Summary: The MC4R Ile269Asn mutation is associated with obesity in the Mexican population. Weight loss interventions such as dietary restriction, phentermine, and RYGB have similar effects on mutation carriers and non-carriers. Therefore, these interventions may be effective in the short-term treatment of obesity in MC4R Ile269Asn mutation carriers.
Review
Endocrinology & Metabolism
Xiang-Guo Lei, Jia-Qi Ruan, Chen Lai, Ziyi Sun, Xi Yang
Summary: Phentermine/topiramate therapy can significantly reduce body weight, and the efficacy is closely related to the dosage, but may increase the risk of nervous system-related adverse events.
Article
Neurosciences
M. J. Carpio, Runbo Gao, Erica Wooner, Christelle A. Cayton, Jocelyn M. Richard
Summary: This study assessed the impact of CIE on cue-elicited alcohol seeking, finding that CIE enhanced responses to cues paired with alcohol, but only in rats with alcohol experience during acute withdrawal. CIE also influenced cue responses and likelihood of entering the alcohol port, even when rats had received alcohol during acute withdrawal.
PSYCHOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
John M. Jakicic, Robert Berkowitz, Paula Bolin, George A. Bray, Jeanne M. Clark, Mace Coday, Caitlin Egan, Mary Evans, John P. Foreyt, Janet E. Fulton, Frank L. Greenway, Edward W. Gregg, Helen P. Hazuda, James O. Hill, Edward S. Horton, Van S. Hubbard, Robert W. Jeffery, Karen C. Johnson, Ruby Johnson, Steven E. Kahn, Anne Kure, Wei Lang, Cora E. Lewis, David M. Nathan, Jennifer Patricio, Anne Peters, Xavier Pi-Sunyer, Henry Pownall, W. Jack Rejeski, Monika Safford, Kerry J. Stewart, Thomas A. Wadden, Michael P. Walkup, Rena R. Wing, Holly Wyatt
Summary: Increased accelerometry-measured moderate-to-vigorous physical activity (MVPA) is associated with decreased risk of cardiovascular disease (CVD) outcomes, emphasizing the need for long-term engagement in MVPA to reduce CVD risk in adults with overweight/obesity and type 2 diabetes.
Article
Chemistry, Medicinal
Kristina. J. J. Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack. N. N. Losso
Summary: This study evaluated the beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and proinflammatory cytokine production related to nonalcoholic fatty liver disease (NAFLD). The results showed that NaP and NaB promoted FAO, regulated lipolysis, and reduced reactive oxygen species production in HepG2 cells. NaP and NaB also increased the mRNA expression of key genes related to FAO in different models. Additionally, only NaP treatment significantly decreased tumor necrosis factor alpha (TNF-alpha) expression in LPS-induced HepG2 cells. The findings suggest that NaP and NaB have potential for further in vivo studies on NAFLD.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Psychiatry
Awirut Oon-arom, Chawisa Suradom, Somdet Srichairatanakool, Suchaya Luewan, Touchwin Petiwathayakorn, Benchalak Maneeton, Narong Maneeton, Suttipong Kawilapat, Manit Srisurapanont
Summary: This study aimed to determine whether serum oxytocin (OT) or corticotrophin-releasing hormone (CRH) levels in the third trimester of pregnancy could predict postpartum depression (PPD) at six weeks after childbirth. The results showed that only high levels of CRH, not OT, in late pregnancy could predict PPD at six weeks postpartum. However, combining CRH levels, late pregnancy stress, and newborn well-being immediately after birth seems to increase the accuracy of PPD prediction.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Stefany D. Primeaux, Robert Dubin, Frank L. Greenway
Summary: This study aimed to investigate the effects of an orlistat mouth rinse on the intake of a high-fat meal. The results showed that the orlistat mouth rinse decreased total and fat calories consumed during the high-fat meal in high-fat consumers, but did not alter calories consumed in low-fat consumers (P < 0.05).
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Candida J. Rebello, Dachuan Zhang, John P. Kirwan, Adam C. Lowe, Carlante J. Emerson, Chelsea L. Kracht, Lori C. Steib, Frank L. Greenway, William D. Johnson, Justin C. Brown
Summary: This study systematically summarized the effect of exercise training on whole-body insulin sensitivity and found that exercise training significantly increases insulin-stimulated glucose disposal. Weight loss may maximize the effect and improve hepatic insulin sensitivity. Differences in tracer methodology contribute to divergent outcomes and should be considered in research conclusions.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Review
Nutrition & Dietetics
Maytinee Srifuengfung, Somporn Srifuengfung, Chalermsri Pummangura, Keerati Pattanaseri, Awirut Oon-arom, Manit Srisurapanont
Summary: This systematic review and meta-analysis found that vitamin D supplements were superior to placebo in reducing depressive symptoms, especially in adults with severe depression. Bolus doses of vitamin D appeared to be more effective than daily oral administration. The use of vitamin D supplements did not affect the drop-out rates of depressed patients. Therefore, vitamin D supplements are safe and effective for individuals with depression.
Article
Endocrinology & Metabolism
John W. Apolzan, Jessica Gokee LaRose, Stephen D. Anton, Robbie A. Beyl, Frank L. Greenway, Edmond P. Wickham, Autumn Lanoye, Melissa N. Harris, Corby K. Martin, Tiffany Bullard, Gary D. Foster, Michelle I. Cardel
Summary: The efficacy of a scalable, virtually delivered, diabetes-tailored weight management program on glycemic control in adults with type 2 diabetes was tested. The results showed that the program had positive and clinically meaningful effects on glycemic control, body weight, and psychosocial outcomes.
NUTRITION & DIABETES
(2023)
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Manit Srisurapanont, Awirut Oon-arom, Chawisa Suradom, Suchaya Luewan, Suttipong Kawilapat
Summary: This study aimed to evaluate the convergent validity of the EPDS and PHQ-9 in Thai pregnant and postpartum women, using the WHODAS as the reference standard. The EPDS and PHQ-9 showed moderate correlations with the WHODAS scores in both antenatal and postpartum participants. The PHQ-9 performed better than the EPDS in distinguishing disability from non-disability in postpartum women.
Article
Physiology
Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Arny A. Ferrando, Jennifer C. Rood, Stefan M. Pasiakos
Summary: The physical performance decrements observed during multi-stressor military operations may be attributed to cellular membrane dysfunction, which can be quantified using phase angle (PhA) derived from bioelectrical impedance analysis (BIA). Positive associations between PhA and performance have been reported, but it is unknown whether changes in PhA indicate acute decrements in performance during military operations.
PHYSIOLOGICAL REPORTS
(2023)
Article
Behavioral Sciences
Zheng Wang, Guillaume Spielmann, Neil Johannsen, Frank Greenway, Brian A. Irving, Marc Dalecki
Summary: This study demonstrates that normo-baric oxygen treatment can significantly improve participants' sequence learning processing speed, and this improvement consolidates after overnight sleep.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Endocrinology & Metabolism
Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway
Summary: Insulin is secreted in pulses to regulate blood glucose levels. In type 2 diabetes, irregularities in insulin secretion occur. Native Americans have a higher prevalence of type 2 diabetes and are genetically predisposed to low beta-cell function. A retrospective chart review of metabolic outcomes in Native Americans showed improvements after physiologic hormone administration, suggesting the need for further investigation in randomized controlled trials.
Article
Multidisciplinary Sciences
Christoph Hoechsmann, Shengping Yang, Jose M. Ordovas, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin
Summary: Weight loss differences between isocaloric high-carbohydrate and high-fat diets are generally small, but individual weight loss varies within diet groups. Genotype patterns may modify diet effects on weight loss.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Candida J. Rebello, Stephen Boue, Ronald J. Levy, Renee Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan
Summary: This study examined the safety of soybean products in Western diets and conducted a dose-escalating clinical trial in older adults with obesity. The results showed that consuming less than 30g of soybean flour per day is beneficial for cardiovascular and overall health, and can reduce the dependence on other food groups and nutrients in older adults with obesity.
