Article
Cell Biology
Chung-Huang Tsai, Pei-Ju Huang, I. T. Lee, Chien-Min Chen, Min Huan Wu
Summary: This study investigates the relationship between diabetes and sarcopenia, focusing on the molecular mechanism of endothelin-1 (ET-1). The results show that ET-1 is positively correlated with HbA1c, creatinine levels, and duration of disease in diabetes patients. ET-1 induces inflammation in muscle cells and decreases energy metabolism in fat, contributing to the development of myopathy. Furthermore, ET-1 suppresses the expression of miR-let-7g-5p in myocytes and adipocytes. Overall, this study reveals a new mechanism of chronic inflammation triggered by ET-1 in patients with hyperglycemia.
Article
Cell Biology
In Hyuk Bang, Dami Park, Youngyi Lee, Hwangeui Cho, Byung-Hyun Park, Eun Ju Bae
Summary: The study demonstrates that myeloid Sirt6 plays a crucial role in adaptive thermogenesis by regulating the differentiation of macrophages and eosinophils, promoting adipocyte beiging. This is achieved through its ability to bind GATA-1 and enhance its transcriptional activity, independent of its deacetylase or ADP-ribosyltransferase function.
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Zhang, Chenfei Li, Liting Yang, Gabriel Komla Adzika, Jeremiah Ong'achwa Machuki, Mingjin Shi, Qi Sun, Hong Sun
Summary: The study aimed to investigate the impact of estrogen deficiency during catecholamine stress on vasomotor function, as well as to utilize estrogen replacement therapy to mitigate the adverse effects of stress on aortic vessels. The results showed that estrogen prevented excessive weight gain during stress, while upregulating eNOS activities and decreasing ET-1 expressions to facilitate vasomotor functions. Overall, estrogen treatments during stress preserved vasomotor functions by preventing excessive intima-media thickening and collagen depositions in the aortic vascular walls.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biology
Choijamts Munkhzul, Ji-Min Lee, Boseon Kim, Thi Thanh My Nguyen, Rehna Paula Ginting, Dahee Jeong, Young-Kook Kim, Min-Woo Lee, Mihye Lee
Summary: Adipose tissue is influenced by type 2 immunity, and in this study, researchers identified miRNA genes that are upregulated by IL-4 stimulation and found that they play a role in regulating the differentiation of APs into beige adipocytes through the Wnt signaling pathway.
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Immunology
Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Giulio Cavalli, Giacomo De Luca, Alessandro Tomelleri, Nicola Boffini, Rebecca De Lorenzo, Annalisa Ruggeri, Patrizia Rovere-Querini, Antonella Castagna, Giovanni Landoni, Moreno Tresoldi, Fabio Ciceri, Alberto Zangrillo, Lorenzo Dagna
Summary: This study shows that IL-1 and IL-6 blockade therapy is more likely to provide a survival advantage in hyper-inflamed COVID-19 patients, especially when initiated before the establishment of severe respiratory failure.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Summary: The study reveals that perturbation of the actin cytoskeleton is not sufficient to induce NF-kappa B activation and IL-6 secretion, but it reduces IL-6-induced activation of STAT3 in Hep3B cells. Additionally, IL-6 receptor proteolysis by ADAM10 is not dependent on the integrity of the actin cytoskeleton.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Paul M. Ridker, Manas Rane
Summary: IL-6 is a pivotal cytokine in innate immunity with a proatherogenic role in cardiovascular disease. Research has explored mechanisms of IL-6 signaling, murine models, and human epidemiological data regarding its utility as a biomarker of vascular risk.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rossella Salemi, Giuseppe Gattuso, Barbara Tomasello, Alessandro Lavoro, Agostino Gaudio, Massimo Libra, Salvatore Santo Signorelli, Saverio Candido
Summary: This study investigated the involvement of IL-6 trans-signaling in DVT and found a strong correlation between the Asp358Ala variant and sIL6-R levels. The high frequency of the Asp358Ala mutation and elevated IL-6 levels in DVT patients may explain the association between IL-6 overactivation and DVT outcome. These findings provide a proof of concept for targeting IL-6 trans-signaling as a new strategy for DVT adjuvant therapy.
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Article
Biochemistry & Molecular Biology
Alexandra Hoepfinger, Thomas Karrasch, Andreas Schaeffler, Andreas Schmid
Summary: Recent investigation has found that Cathelicidin antimicrobial peptide (CAMP) plays a significant role in infection defense and innate immunity processes in adipose tissue. However, its regulation and functions as an adipokine in metabolic contexts are not well understood. This study examined the regulation of CAMP levels during oral glucose tolerance tests (OGTTs) and found that glucose positively regulates systemic CAMP in a postprandial manner, independent of its impact on adipocyte CAMP expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Meng Zhang, Jianing Gao, Xuyang Zhao, Mingming Zhao, Dong Ma, Xinhua Zhang, Dongping Tian, Bing Pan, Xiaoxiang Yan, Jianwei Wu, Xia Meng, Huiyong Yin, Lemin Zheng
Summary: The study revealed that p38 alpha in macrophages aggravates artery injury by phosphorylating MKL1 and increasing IL-6 expression after vascular injury, which in turn affects the process of re-endothelialization.
Article
Cell Biology
Gabriel Komla Adzika, Hongjian Hou, Adebayo Oluwafemi Adekunle, Ruqayya Rizvi, Seyram Yao Adzraku, Kexue Li, Qi-Ming Deng, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Jeremiah Ong'achwa Machuki, Wenkang Shang, Tongtong Ma, Stephane Koda, Xianluo Ma, Hong Sun
Summary: The study aimed to prevent pathological cardiac hypertrophy during chronic stress by modulating cardiac and inflammatory responses. The combination of Amlexanox and Forskolin showed the highest efficacy in regulating adaptive inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Athina Dimosiari, Dimitrios Patoulias, George D. Kitas, Theodoros Dimitroulas
Summary: Cardiovascular disease (CVD) is a global pandemic of the 21st century, with high morbidity, mortality, and economic burden. Inflammation plays a crucial role in the development and progression of CVD, particularly the NLRP3 inflammasome-IL-1/IL-6 pathway, which has been studied as a potential treatment target. However, evidence on the cardiovascular safety of IL-1 and IL-6 antagonists in patients without rheumatic disease is limited and conflicting. This review summarizes and critically presents the available evidence from randomized controlled trials and observational studies regarding the use of IL-1 and IL-6 antagonists in the treatment of CVD.
JOURNAL OF CLINICAL MEDICINE
(2023)