Article
Nutrition & Dietetics
Claudia Vetrani, Ludovica Verde, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
Summary: High adherence to the Mediterranean Diet, particularly the consumption of fish, is associated with decreased insulin resistance in individuals with overweight/obesity.
Article
Endocrinology & Metabolism
Rana Halloun, Alfonso Galderisi, Sonia Caprio, Ram Weiss
Summary: This study found that adipose tissue insulin resistance does not protect against increases in the degree of obesity in youth with obesity, and skeletal muscle insulin resistance is not associated with increases in the degree of obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Pilarski, Marta Pelczynska, Anna Koperska, Agnieszka Seraszek-Jaros, Monika Szulinska, Pawel Bogdanski
Summary: This study aimed to determine the association between vaspin concentration and metabolic disorders in obese individuals. The results showed that serum vaspin concentrations were significantly higher in the obese group compared to the control group. The findings suggest that vaspin may be a useful diagnostic parameter for obesity-related complications.
Review
Food Science & Technology
Gary Williamson
Summary: Dietary polyphenols can interact with glucose transporters in the small intestine and modulate glucose uptake after eating or drinking. For example, apple polyphenol phlorizin inhibits glucose transporter-1 and is converted to phloretin in the intestinal lumen, which can effectively inhibit glucose transporter-2. As a result, an apple extract rich in phlorizin can lower blood glucose and insulin levels in healthy individuals after consuming glucose challenge. However, the olive phenolic oleuropein inhibits glucose transporter-2, but its inhibition strength is not enough to modulate blood glucose in healthy volunteers after glucose challenge. In addition, little is known about the acute effects of polyphenols on secondary effects induced by glucose consumption, apart from their postprandial effects on glucose, insulin, and some incretin hormones.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Nutrition & Dietetics
Akihiro Yoshida, Takao Kimura, Katsuhiko Tsunekawa, Yoshifumi Shoho, Yoshimaro Yanagawa, Osamu Araki, Tomoyuki Aoki, Takayuki Ogiwara, Masami Murakami
Summary: The age-related sex difference in glucose tolerance was investigated in 1156 participants, revealing that the superior glucose tolerance in females is more pronounced in young females and attenuated in middle-aged females.
Article
Nutrition & Dietetics
Maria Giovanna Lupo, Elisa Brilli, Virginia De Vito, Germano Tarantino, Stefania Sut, Irene Ferrarese, Giovanni Panighel, Daniela Gabbia, Sara De Martin, Stefano Dall'Acqua, Nicola Ferri
Summary: This study developed a new oral formulation of berberine based on Sucrosomial (R) technology and demonstrated its effectiveness in improving insulin resistance. The results showed that Sucrosomial (R) berberine had significant effects on proteins related to insulin resistance in vitro, and its oral administration increased the plasma concentration of berberine and reduced insulin resistance in mice fed with a high-fat diet.
Article
Multidisciplinary Sciences
Michal Kukla, Tomasz Menzyk, Marcin Dembinski, Marek Winiarski, Aleksander Garlicki, Monika Bociaga-Jasik, Magdalena Skonieczna, Dorota Hudy, Barbara Maziarz, Beata Kusnierz-Cabala, Lubomir Skladany, Ivica Grgurevic, Malgorzata Wojcik-Bugajska, Tomasz Grodzicki, Dominika Stygar, Tomasz Rogula
Summary: Chemerin and omentin levels were significantly decreased in COVID-19 patients compared to healthy controls, but did not correlate with disease severity. Elevated GGT activity may be the only predictive factor for a more severe COVID-19 course.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Quan Wen, Rasmus Stenlid, Azazul Islam Chowdhury, Iris Ciba, Banu Aydin, Sara Y. Cerenius, Hannes Manell, Anders Forslund, Peter Bergsten
Summary: The study investigated the effect of metformin on insulin secretion in isolated islets treated with palmitate and its implications for children with obesity. It was found that adding metformin after 1 day of palmitate exposure increased insulin secretion, while adding metformin after 0.5 days reduced insulin secretion. Additionally, metformin treatment in children with obesity improved glycemic and lipid levels and decreased insulin levels during OGTT.
Article
Endocrinology & Metabolism
Daniela Vejrazkova, Marketa Vankova, Josef Vcelak, Hana Krejci, Katerina Anderlova, Andrea Tura, Giovanni Pacini, Alena Sumova, Martin Sladek, Bela Bendlova
Summary: Variability in the MTNR1B gene affects the development of type 2 diabetes mellitus. In this study, a Czech population sample was used to compare the distribution of the rs10830963 genetic variant between individuals with different glucose tolerance. The variant was found to be associated with impaired early phase of beta cell function and higher blood glucose levels, even in healthy individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Lina Sakhneny, Laura Mueller, Anat Schonblum, Sivan Azaria, Guzel Burganova, Alona Epshtein, Abigail Isaacson, Heather Wilson, Francesca M. Spagnoli, Limor Landsman
Summary: Glucose homeostasis in the body depends on insulin secretion from mature pancreatic beta cells. This study identifies BMP4 as a critical component in regulating beta cell function, with pericytes as the primary source of BMP4 in the pancreatic microenvironment. The timely production of BMP4 in the islet niche promotes beta cell functional maturation.
DEVELOPMENTAL CELL
(2021)
Article
Endocrinology & Metabolism
Mujtaba H. Shah, Paolo Piaggi, Helen C. Looker, Ethan Paddock, Jonathan Krakoff, Douglas C. Chang
Summary: The study found that lower MCRI is associated with an unfavorable metabolic phenotype and an increased risk of incident type 2 diabetes.
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Arianna Solito, Nicole Bozzi Cionci, Matteo Calgaro, Marina Caputo, Lucia Vannini, Iderina Hasballa, Francesca Archero, Enza Giglione, Roberta Ricotti, Gillian Elisabeth Walker, Antonella Petri, Emanuela Agosti, Giorgio Bellomo, Gianluca Aimaretti, Gianni Bona, Simonetta Bellone, Angela Amoruso, Marco Pane, Diana Di Gioia, Nicola Vitulo, Flavia Prodam
Summary: This study evaluated the impact of probiotics on weight, metabolism, gut microbial groups, and functionality in youths with obesity through a double-blind, randomized control trial. The results showed that an 8-week treatment with B. breve BR03 and B632 had beneficial effects on insulin sensitivity in youths with obesity, suggesting that microbiota functionality may influence metabolic responses to probiotics and tailored probiotic treatments could be an additional strategy for obesity.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jarlei Fiamoncini, Carlos M. Donado-Pestana, Graziela Biude Silva Duarte, Milena Rundle, Elizabeth Louise Thomas, Yoana Kiselova-Kaneva, Thomas E. Gundersen, Diana Bunzel, Jean-Pierre Trezzi, Sabine E. Kulling, Karsten Hiller, Denise Sonntag, Diana Ivanova, Lorraine Brennan, Suzan Wopereis, Ben van Ommen, Gary Frost, Jimmy Bell, Christian A. Drevon, Hannelore Daniel
Summary: This study identified markers associated with differential responses to an OGTT in a population of healthy adults. It found that individuals with distinct postprandial glucose profiles displayed higher postprandial glucose levels and increased fasting plasma concentrations of known biomarkers of insulin resistance. The study suggests that analysis of the corresponding metabolite profile in a fasting blood sample may allow for early identification of individuals at risk for insulin resistance.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Claudia Kappes, Robert Stein, Antje Koerner, Andreas Merkenschlager, Wieland Kiess
Summary: This literature review investigates the effects of stress exposure, including the COVID-19 pandemic, on obesity risk in children and adolescents. It highlights the biological and behavioral alterations associated with stress exposure that contribute to the development of obesity. However, there is a lack of longitudinal studies exploring the relationships between environmental, behavioral, and biological factors, and results are mixed. Intervention programs targeting stress reduction through mindfulness may offer a promising approach in preventing and treating childhood and adolescent obesity.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Nutrition & Dietetics
Sophie Vinoy, Janina Goletzke, Maryam Rakhshandehroo, Lisa Schweitzer, Matthieu Flourakis, Antje Koerner, Ute Alexy, Evert M. van Schothorst, Antonio Ceriello, Julia K. Zakrzewski-Fruer, Anette Buyken
Summary: In June 2021, a workshop organized by the European branch of ILSI addressed the role of postprandial glycaemic response in pediatric health and highlighted research gaps in this area. The workshop emphasized the importance of understanding glycaemic responses in pediatric populations, and the changes in metabolism and dietary needs from infancy to adolescence. The lack of scientific data on glucose and insulin profiles in response to commonly consumed foods by children, as well as the need for long-term evidence and suitable predictors for future health effects, were identified as significant research gaps.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Anja Saalbach, Ulf Anderegg, Ralph Wendt, Joachim Beige, Anette Bachmann, Nora Kloeting, Matthias Blueher, Ming-Zhi Zhang, Raymond C. Harris, Michael Stumvoll, Anke Toenjes, Thomas Ebert
Summary: Kidney fibrosis, a major factor in chronic kidney disease (CKD), leads to irreversible organ function loss. This study investigated the association of the soluble form of Thymocyte differentiation antigen-1 (sThy-1) with clinical parameters in CKD patients receiving hemodialysis. The study also examined Thy-1 tissue expression in a mouse model of diabetic CKD. The results showed that sThy-1 levels increased with worsening renal function, regardless of the presence of diabetes. Serum creatinine was found to be a major predictor of sThy-1 levels. Additionally, sThy-1 was found to be an independent predictor of markers of renal function. The study suggests that Thy-1 may have a role in controlling kidney fibrosis and could potentially be used as a renal antifibrotic factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Endocrinology & Metabolism
Wieland Kiess, Anette Stoltze, Anna S. Kirstein, Julia Gesing, Robert Stein, Antje Koerner, Roland Pfaeffle
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Julius Lars Breinker, Anika Kaspar, Elena Sergeyev, Antje Koerner, Wieland Kiess, Anja Hilbert
Summary: Multimodal obesity treatments for children and adolescents have limited effectiveness and high dropout rates. The impact of clinical and sociodemographic factors on treatment outcomes remains unclear. This study investigated predictors of treatment success and adherence in a multimodal obesity treatment over 12 months. The results suggest the importance of early intervention for juvenile obesity and highlight the potential positive effect of eating disorder psychopathology on controlled food intake. Challenges due to the COVID-19 pandemic also need to be addressed.
Article
Genetics & Heredity
Janine Molder, Esther Guiu-Jurado, Yusef Moulla, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Michael Stumvoll, Peter Kovacs, Matthias Blueher, Nora Kloeting
Summary: This study aimed to investigate the influence of SNP rs10487505 on leptin mRNA expression and obesity-related parameters. The researchers found that rs10487505 is associated with lower leptin levels in women and a lower mean BMI in women carrying the C allele. However, no association was found between rs10487505 and leptin mRNA expression in adipose tissue.
Article
Biochemistry & Molecular Biology
Robert Stein, Florian Koutny, Johannes Riedel, Natascha Doerr, Klara Meyer, Marco Colombo, Mandy Vogel, Christian Heinz Anderwald, Matthias Blueher, Wieland Kiess, Antje Koerner, Daniel Weghuber
Summary: The single point insulin sensitivity estimator (SPISE) is a fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. This study evaluated the distribution and correlation of SPISE in children and adolescents with overweight or obesity, and assessed its role as a prognostic marker for future dysglycemia. The results showed that SPISE decreased with age and had a modest correlation with established fasting markers of insulin resistance. SPISE was found to be a better prognostic marker for future dysglycemia than other fasting indexes.
Article
Endocrinology & Metabolism
Noa Ofir, Yuval Mizrakli, Yariv Greenshpan, Yftach Gepner, Omri Sharabi, Gal Tsaban, Hila Zelicha, Anat Yaskolka Meir, Uta Ceglarek, Michael Stumvoll, Matthias Blueher, Yoash Chassidim, Assaf Rudich, Anat Reiner-Benaim, Iris Shai, Ilan Shelef, Roi Gazit
Summary: In this study, the researchers found that long-term weight loss can temporarily reduce bone marrow adipose tissue (BMAT) in adults, with more prominent effects in younger adults. The storage and dynamics of BMAT are largely independent of other fat depots or cardio-metabolic risk markers, highlighting its unique functions.
Review
Medicine, General & Internal
Lara Heuft, Jenny Voigt, Lars Selig, Michael Stumvoll, Haiko Schloegl, Thorsten Kaiser
Summary: This study investigates the role of clinical decision support systems (CDSS) in the diagnosis of refeeding syndrome (RFS) and highlights the importance of identifying high-risk patients. The literature review reveals that malnourished patients with RFS have higher mortality rates and an increased risk of ICU admission compared to those without RFS. The use of CDSS significantly improves the detection and diagnosis of RFS.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Inka Rapoehn, Ivet Elias, Juliane Weiner, Anna Pujol, Stephanie Kehr, Alexandra Chadt, Hadi Al-Hasani, Ralph Burkhardt, Nora Kloeting, Michael Stumvoll, Fatima Bosch, Peter Kovacs, John T. Heiker, Jana Breitfeld
Summary: Adipose tissue inflammation and insulin resistance are important factors in the development of metabolic diseases resulting from overweight and obesity. The serpin vaspin has compensatory roles in inflammation and insulin resistance. A new transgenic mouse line with human vaspin expression in adipose tissue has been developed, which showed improved metabolic parameters and increased energy expenditure under high-fat diet conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marleen Wuerfel, Matthias Blueher, Michael Stumvoll, Thomas Ebert, Peter Kovacs, Anke Toenjes, Jana Breitfeld
Summary: Adipokines play a crucial role in the development of obesity and its associated metabolic and cardiovascular complications. While some adipokines have been identified and studied, many regulatory mechanisms remain unclear, hindering their clinical application. However, due to their complex metabolic properties, adipokines hold great potential as biomarkers and treatment strategies for obesity and related disorders. This review summarizes current clinical studies on adipokines and their potential diagnostic and therapeutic use in obesity and metabolic disorders, highlighting the promising clinical application of fibroblast growth factors (FGF)-19, FGF-21, and leptin.
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Gastroenterology & Hepatology
Evelyn Medawar, Frauke Beyer, Ronja Thieleking, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Madlen Reinicke, Rima Chakaroun, Martin von Bergen, Michael Stumvoll, Arno Villringer, A. Veronica Witte
Summary: This study investigated the effects of high-dosed prebiotic fiber on reward-related food decision-making in overweight young adults. The results showed that prebiotic intake decreased brain activation towards high-caloric food stimuli and caused shifts in gut microbiota.
Article
Endocrinology & Metabolism
Jana Breitfeld, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Voelker, Henry Voelzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Juergen Kratzsch, Joachim Thiery, Berend Isermann, Markus Loeffler, Nora Kloeting, Matthias Blueher, Michael Stumvoll, John T. Heiker, Anke Toenjes, Markus Scholz, Peter Kovacs
Summary: This study found a correlation between genetic variants of the Vaspin gene and serum Vaspin levels, and further revealed the causal role of Vaspin in lipid metabolism.
Letter
Health Care Sciences & Services
Robert Stein, Eric Goepel, Daniel Weghuber, Maximiliane Chiara Hammel, Mandy Vogel, Wieland Kiess, Antje Koerner
LANCET REGIONAL HEALTH-EUROPE
(2023)