Article
Pharmacology & Pharmacy
Ghulam Md Ashraf, Badrah S. Alghamdi, Fahad S. Alshehri, Mohammad Zubair Alam, Haythum O. Tayeb, Frank Tarazi
Summary: The study found that the antidiabetic drug EMPA effectively attenuated the body weight gain induced by the atypical antipsychotic drug Ola in female Wistar rats. The impact of Ola on female Wistar rats was significantly different from male rats, indicating a potential gender difference in body weight gain caused by antipsychotic drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ochuko L. Erukainure, Motlalepula G. Matsabisa, Veronica F. Salau, Kolawole A. Olofinsan, Sunday O. Oyedemi, Chika I. Chukwuma, Adeline Lum Nde, Md. Shahidul Islam
Summary: Reduced glucose uptake and utilization has been linked to obesity and its complications. This study found that cannabinoid-stimulated glucose uptake increased antioxidative activities, modulated cholinergic and purinergic dysfunctions, and improved glucose-lipid homeostasis in adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Russell T. Turner, Carmen P. Wong, Kristina M. Fosse, Adam J. Branscum, Urszula T. Iwaniec
Summary: The study compared the effects of increasing leptin levels through gene therapy and conventional caloric restriction in preventing weight gain in rats. Both methods were equally effective in preventing weight gain, but differed in energy intake, energy expenditure, adipokine levels, and body composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sarbani Ghoshal, Sandip Mukherjee, Molee Chakraborty, Eliwaza Naomi Msengi, Jake Haubner, Anutosh Chakraborty
Summary: The deletion of Ip6k1 protects mice from age-induced metabolic dysfunction by preventing the increase in body weight and fat mass, improving insulin sensitivity, and enhancing carbohydrate oxidation efficiency. Targeting Ip6k1 may delay the development of age-related metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Cordoba-Sosa Gabriela, Nicolas-Toledo Leticia, Cervantes-Rodriguez Margarita, Xelhuantzi-Arreguin Nicte, Arteaga-Castaneda Maria de Lourdes, Zambrano Elena, Cuevas-Romero Estela, Rodriguez-Antolin Jorge
Summary: This study found that maternal consumption of a high-sugar diet leads to adverse effects on perigonadal adipose tissue and testes in adult offspring. The enlargement of adipose tissue and inflammatory processes in the testes may be associated with gestational and lactational diet.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Chantal R. Ryan, Michael S. Finch, Tyler C. Dunham, Jensen E. Murphy, Brian D. Roy, Rebecca E. K. MacPherson
Summary: This study suggests that creatine supplementation may affect mitochondrial markers in adipose tissue, leading to UCP1-independent thermogenesis. The responses to supplementation vary based on sex and depot-specific differences in adipose tissue.
Article
Medicine, General & Internal
Renata Saucedo, Maria Isabel Pena-Cano, Mary Flor Diaz-Velazquez, Aldo Ferreira-Hermosillo, Juan Mario Solis-Paredes, Ignacio Camacho-Arroyo, Jorge Valencia-Ortega
Summary: This study found that excessive and adequate gestational weight gain (GWG) were associated with higher expressions of inflammatory genes in visceral adipose tissue (VAT) compared to insufficient GWG. Additionally, GWG was positively correlated with newborn weight.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Melanie Raquel Martinez-Cignoni, Agusti Gonzalez-Vicens, Andrea Moran-Costoya, Ana Maria Proenza, Magdalena Gianotti, Adamo Valle, Isabel Llado
Summary: The study suggests that in the context of diabetes and obesity, estradiol may lose its cardioprotective role and even contribute to greater metabolic alterations. Ovariectomy attenuated the diabetic condition and metabolic dysfunction in fa/fa rats, indicating a potential negative impact of estradiol in obese-diabetic individuals. Adipose tissue from ovariectomized rats showed a healthier expansion pattern, which could help maintain tissue function and reduce inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hye-Jin Lee, Bo-Yeong Jin, Mi-Rae Park, Nam Hoon Kim, Kwan Sik Seo, Yong Taek Jeong, Tsutomu Wada, Jun-Seok Lee, Sang-Hyun Choi, Dong-Hoon Kim
Summary: This study investigated the role of modulation of the WAT vasculature in regulating RWG after CR and found that it can attenuate RWG by suppressing hyperphagia and increasing BAT thermogenesis and WAT browning.
Article
Biochemistry & Molecular Biology
Pilar Rodriguez-Rodriguez, Ignacio Monedero-Cobeta, David Ramiro-Cortijo, Sophida Puthong, Begona Quintana-Villamandos, Alicia Gil-Ramirez, Silvia Canas, Santiago Ruvira, Silvia M. Arribas
Summary: Low birth weight and accelerated growth during lactation are associated with cardiometabolic disease development. Slower postnatal growth can improve early cardiovascular alterations induced by fetal undernutrition, especially during the exclusive lactation period.
Article
Nutrition & Dietetics
Franciely Alves da Silva, Lorena Silva Freire, Thiago da Rosa Lima, Stephanie Figueiredo Santos, Bibiana Mozzaquatro Gai, Edson Moleta Colodel, Eudes Thiago Pereira Avila, Amilcar Sabino Damazo, Mayara Peron Pereira, Nair Honda Kawashita
Summary: This study investigated whether the consumption of diets with different fat levels and fructose drinks leads to cardiovascular damage in newly weaned rats. The results showed that rats in the high-fat and very high-fat diet groups developed obesity-related cardiovascular damage, including cardiac injury and left ventricular hypertrophy. The study suggests that changes in the leptin-signal transducer and activator of transcription 3 pathway are associated with the occurrence of left ventricular hypertrophy.
Article
Agriculture, Dairy & Animal Science
S. Kargar, M. Bahadori-Moghaddam, S. M. Ghoreishi, A. Akhlaghi, M. Kanani, A. Pazoki, M. H. Ghaffari
Summary: In this study, replacing pasteurized waste milk with transition milk (TM) was found to improve growth performance and health of dairy calves. Calves fed higher levels of TM showed increased body weight gain, higher feed efficiency, and lower incidence of diarrhea compared to the control group. These findings suggest that providing TM to dairy calves at an early stage of life could support higher growth rates and health benefits.
Article
Biochemistry & Molecular Biology
Hala A. Hafez, Ali M. Atoom, Rana H. M. Khafaga, Sara A. Shaker, Maher A. Kamel, Nagwa M. Assem, Shimaa A. Mahmoud
Summary: The study found that the therapeutic dose of SOF has adverse effects on mitochondrial biogenesis and function in different tissues of young female rats, with the most significant effects observed in ovarian tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Berk, Karolina Konstantynowicz-Nowicka, Tomasz Charytoniuk, Ewa Harasim-Symbor, Adrian Chabowski
Summary: Available data suggests that cannabidiol (CBD) can improve symptoms of insulin resistance by modulating sphingolipid concentrations. CBD reduces ceramide content in adipose tissues, enhancing insulin sensitivity. Therefore, CBD may be considered as a potential therapeutic strategy for treating insulin resistance and metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Niketa A. Patel, Ashley Lui, Andrea N. Trujillo, Zeinab Y. Motawe, Deena Bader, Jane Schuster, Andrea Burgess, Natascha G. Alves, Michiko Jo, Jerome W. Breslin
Summary: This study identified mediators in the peri-lymphatic adipose tissue (PLAT) that are altered in obese versus lean Zucker rats, with a focus on potential sex differences. It was found that obese male and female rats show increased inflammation, but they have distinct signals in terms of protein and lncRNA expression. These findings provide valuable insights for the development of therapeutics for obesity-induced inflammation.
Review
Neurosciences
Sari G. Ferber, Reut Hazani, Gal Shoval, Aron Weller
Summary: Borderline Personality Disorder (BPD) is a chronic debilitating psychiatric disorder characterized by emotional instability, chaotic interpersonal relationships, and cognitive disturbances. Studies have shown compromised brain regions, the hypothalamus and the corticolimbic system, in BPD patients, with potential involvement of the endocannabinoid system (ECS) in symptom improvement.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Noa Hazut, Kayla Rapps, Aron Weller, Abraham J. Susswein
Summary: Nitric oxide (NO) has complex, state-dependent effects on both the quantity of food eaten and on patterns of feeding in rats, mediating feeding inhibition caused by satiation through unconventional pathways.
Article
Biochemistry & Molecular Biology
Sari Goldstein Ferber, Aron Weller, Michal Ben-Shachar, Gil Klinger, Ronny Geva
Summary: This paper proposes a theory on the ontogenetic-neurobiological basis of self-regulation, suggesting that it is a complex mechanism starting from early brainstem development and progressing to cortical control. The paper discusses the synchronous reactivity between the sympathetic and parasympathetic systems, as well as the development of cardiovascular and white matter, in creating self-regulatory functions. It also proposes hypotheses for further investigation of the clock circuitry and its associations with other biological clocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Danielle Hen-Shoval, Aron Weller, Abraham Weizman, Gal Shoval
Summary: Depression and anxiety disorders are common and growing mental health concerns in adolescents, with antidepressant medication use increasing accordingly. Cannabis use may affect the efficacy of antidepressants, particularly among adolescents, highlighting the need for further research in this area.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Neurosciences
Sari Goldstein Ferber, Aron Weller, Rotem Maor, Yuval Feldman, Yossi Harel-Fisch, Mario Mikulincer
Summary: The study found that perceived support in close relationships was negatively associated with the intensity of depression, anxiety, OCD, and PTSD. Larger rings of potential support, such as perceived belongingness to a community and trust in government, were also negatively related to anxiety and depression but positively associated with the intensity of OCD and PTSD.
ANXIETY STRESS AND COPING
(2022)
Editorial Material
Neurosciences
Sari Goldstein Ferber, Ronny Geva, Aron Weller
Summary: In this editorial, the neurobiological processes underlying the early emergence of awareness are discussed, focusing on the timing and mechanism of the mind's integration into the body. A developmental perspective based on Perceptual Control Theory is proposed, highlighting the coupling of behavioral manifestations with underlying mechanisms on various levels. The potential interference of pharmacological treatments administered to preterm infants is also addressed, emphasizing the importance of considering the side effects of current pharmaceuticals in the development of novel treatments.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Environmental Sciences
Maya Levhar, Anat Schonblum, Liat Arnon, Yaron Michael, Liat Salzer Sheelo, Michal Eisner, Eran Hadar, Israel Meizner, Arnon Wiznitzer, Aron Weller, Lee Koren, Keren Agay-Shay
Summary: The study found that exposure to more greenness during the first trimester was associated with reduced maternal cortisol levels. This association was particularly strong among those of lower sociodemographic status. The findings suggest potential benefits of promoting greenness exposure during early pregnancy for disadvantaged populations.
ENVIRONMENTAL RESEARCH
(2022)
Article
Psychiatry
Sari Goldstein Ferber, Aron Weller
Summary: The COVID-19 pandemic has highlighted the need for remote psychotherapy and explores its effectiveness in treating patients. The article introduces the concept of 'the inanimate third', referring to the electronic device used in therapy, and discusses its objectivity compared to the subjective emotional processes involved. It also addresses emotional themes relevant to the pandemic and evaluates the existence of transference and countertransference processes in remote therapy. The term 'social paradox' is suggested to describe the conflicting nature of digital media symbolizing both distance and intimacy, separation and unity. The article concludes that therapeutic dialogue can help deal with the social paradox by eliminating its conflicting elements.
BRITISH JOURNAL OF PSYCHOTHERAPY
(2022)
Review
Psychiatry
Reut Hazani, Michal Lavidor, Aron Weller
Summary: This study aims to evaluate the efficacy of available treatments for social deficits in different animal models of schizophrenia. The results showed that treatment significantly improved social deficit in almost all models. There were significant subgroup differences across models and treatment subgroups. The perinatal and adult pharmacological models showed the most substantial influence, and atypical antipsychotic drugs had the highest effect within each model subgroup.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Endocrinology & Metabolism
Kayla Rapps, Tatiana Kisliouk, Asaf Marco, Aron Weller, Noam Meiri
Summary: KDM4D plays a role in energy balance by regulating the expression of AgRP. Downregulation of Kdm4d mRNA results in enrichment of H3K9me2 on the AgRP promoter and transcriptional repression of AgRP. Upregulation of Kdm4d mRNA in calorically restricted rats leads to demethylation of H3K9 on the AgRP promoter and transcriptional increase of AgRP. Inhibition of KDM4D activity leads to transcriptional repression of AgRP, inhibiting hunger.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Sari Goldstein Ferber, Gal Shoval, Rodolfo Rossi, Viviana Trezza, Giorgio Di Lorenzo, Gil Zalsman, Aron Weller, J. John Mann
Summary: The psychiatric burden related to COVID-19 is not limited to a single diagnosis, but spans across multiple diagnostic categories. Understanding the diverse range of symptoms associated with COVID-19 can lead to better prevention and treatment strategies.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Biochemistry & Molecular Biology
Danielle Hen-Shoval, Lital Moshe, Talia Indig-Naimer, Raphael Mechoulam, Gal Shoval, Gil Zalsman, Natalya M. Kogan, Aron Weller
Summary: This study explored the anti-depressant effects of Cannabidiolic Acid-Methyl Ester (CBDA-ME) in female Wistar-Kyoto (WKY) rats and found that females require higher doses of CBDA-ME to induce anti-depressant effects. Furthermore, the anti-depressant effects of CBDA-ME in females may be related to serum Brain-Derived Neurotrophic Factor (BDNF), endocannabinoid levels, and hippocampal expression of Fatty Acid Amide Hydrolase (FAAH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ygal Rotenstreich, Inbal Sharvit-Ginon, Ifat Sher, Ofira Zloto, Ido Didi Fabian, Amir Abd-Elkader, Aron Weller, Anthony Heymann, Michal Schnaider Beeri, Ramit Ravona-Springer
Summary: This study compared the retinal layers' thickness between apolipoprotein E (APOE) sigma 4 carriers and non-carriers, and found that asymptomatic midlife APOE sigma 4 carriers at high Alzheimer's disease (AD) risk have thicker macular layers.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Meeting Abstract
Ophthalmology
Ygal Rotenstreich, Yael Lustig, Inbal Sharvit-Ginon, Yael Feldman, Michael Mrejen, Michal Schnaider Beeri, Aron Weller, Ramit Ravona-Springer, Ifat Sher-Rosenthal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Shivang Parikh, Roma Parikh, Keren Michael, Lior Bikovski, Georgina Barnabas, Mariya Mardamshina, Rina Hemi, Paulee Manich, Nir Goldstein, Hagar Malcov-Brog, Tom Ben-Dov, Ohad Glaich, Daphna Liber, Yael Bornstein, Koral Goltseker, Roy Ben-Bezalel, Mor Pavlovsky, Tamar Golan, Liron Spitzer, Hagit Matz, Pinchas Gonen, Ruth Percik, Lior Leibou, Tomer Perluk, Gil Ast, Jacob Frand, Ronen Brenner, Tamar Ziv, Mehdi Khaled, Shamgar Ben-Eliyahu, Segev Barak, Orit Karnieli-Miller, Eran Levin, Yftach Gepner, Ram Weiss, Paul Pfluger, Aron Weller, Carmit Levy
Summary: Ultraviolet exposure on the skin increases food intake and body weight in males, but not in females. This sexual dimorphism is mediated by the expression of ghrelin in skin adipocytes. These findings highlight the significant metabolic differences between males and females and the important role of the skin in energy homeostasis. Furthermore, this research may lead to potential sex-based treatments for endocrine-related diseases.