Article
Health Care Sciences & Services
Ilaria Girolami, Stefania Neri, Albino Eccher, Matteo Brunelli, Mattew Hanna, Liron Pantanowitz, Esther Hanspeter, Guido Mazzoleni
Summary: This study reviewed the outcome of 12 years of telepathology in the Italian northern region of South Tyrol. The results showed that after an initial validation phase, telepathology had a sensitivity of 65% and specificity of 100%. There were 2058 intraoperative consultations handled by telepathology, with the majority of cases being breast sentinel lymph nodes. Overall, the sensitivity and specificity were 65% and 100%, respectively.
Article
Oncology
Monica D. Levine, David A. Barrington, Heather Hampel, Paul J. Goodfellow, David E. Cohn
Summary: This study proposes an optimized diagnostic algorithm for newly diagnosed endometrial cancer patients, aiming to improve diagnosis and save costs through upfront multi-gene panel testing. The results show that adopting this algorithm could lead to cost savings of $259 per patient and potentially identify more patients with Lynch syndrome and BRCA1/BRCA2 genetic variants.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Brandie Heald, Sara Mokhtary, Sarah M. Nielsen, Susan Rojahn, Shan Yang, Scott T. Michalski, Edward D. Esplin
Summary: This study assessed the prevalence and clinical impact of pathogenic germline variants (PGVs) in hereditary uterine cancer patients. The results indicate that focusing on Lynch syndrome genes and PTEN and limiting testing to patients under 50 years old may overlook a significant proportion of patients with actionable PGVs.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Peter Leonard Schrammen, Narmin Ghaffari Laleh, Amelie Echle, Daniel Truhn, Volkmar Schulz, Titus J. Brinker, Hermann Brenner, Jenny Chang-Claude, Elizabeth Alwers, Alexander Brobeil, Matthias Kloor, Lara R. Heij, Dirk Jager, Christian Trautwein, Heike Grabsch, Philip Quirke, Nicholas P. West, Michael Hoffmeister, Jakob Nikolas Kather
Summary: SLAM is a simple yet powerful computational pathology method that utilizes a neural network to predict tumor presence and genetic alterations directly from histopathology slides, without the need for complex manual annotations. It demonstrates high reliability and accuracy in clinically relevant tasks, making it a valuable tool for disease analysis.
JOURNAL OF PATHOLOGY
(2022)
Review
Oncology
Alicia Leon-Castillo
Summary: The traditional pathological classification of endometrial carcinomas based on morphologic features is limited in reflecting the biological diversity and reproducibility. Recent studies have shown the strong prognostic value and potential for treatment decisions of molecular endometrial carcinoma subgroups. This has led to a transition towards an integrated histological and molecular classification system.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Daniel Spinosa, Tatiana Acosta, Janice Wong, Kelli Kurtovic, Jennifer Mewshaw, Sarah Collins, Noah Kauff, Laura J. Havrilesky, Kyle C. Strickland, Rebecca A. Previs
Summary: The study evaluated the feasibility and effectiveness of using QI for universal screening to diagnose Lynch syndrome in uterine cancer patients, with results showing significant improvements in screening rates and genetic diagnoses post-implementation.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Gulsen Dogan Durdag, Songul Alemdaroglu, Filiz Aka Bolat, Safak Yilmaz Baran, Seda Yuksel Simsek, Husnu Celik
Summary: This study retrospectively analyzed data from 223 cases of endometrial cancer surgery at a tertiary hospital from 2012 to 2019, and found that the accuracy of FS in predicting PS results was 76.23% for histology, 75.45% for grade, 85.31% for depth of myometrial invasion, and 95.45% for tumor diameter. Surgery based on FS results led to undertreatment in 4 patients, and metastatic lymph node involvement was found in only 35.3-50.0% of cases with high risk parameters on FS.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Rose B. McGee, Ninad Oak, Lynn Harrison, Ke Xu, Regina Nuccio, Alise K. Blake, Roya Mostafavi, Sara Lewis, Leslie M. Taylor, Manish Kubal, Annastasia Ouma, Stacy J. Hines-Dowell, Cheng Cheng, Larissa V. Furtado, Kim E. Nichols
Summary: This study retrospectively examined the prevalence and impact of pathogenic variants in adult-onset cancer predisposition genes (aoCPGs) in pediatric tumors. They found that a small percentage of patients had tumors with aoCPG variants, with some of these variants being of germline origin. These variants were associated with alterations in tumor molecular profiles, but were not commonly used to change treatment decisions in pediatric cancers.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Danielle A. Kapustin, Jun Yun, Vivian Su, Samuel J. Rubin, Ippolito Modica, Daniel Chung, Jun Fan, Mohemmed N. Khan, Raymond L. Chai, Michael Karasick, Scott Doyle, Margaret Brandwein-Weber, Mark L. Urken
Summary: This study developed an interactive form for use during frozen section timeouts, conducted over Zoom calls, to improve communication and documentation. The results showed that this technique can enhance intraoperative communication, increase transparency, and potentially eliminate uncertainty regarding margin status and tumor clearance. This new technique promises an improved standard of care.
Article
Oncology
Zhi-Gang Yao, Bei-Bei Lv, Hai-Yan Jing, Wen-Jing Su, Jia-Mei Li, Hui Fan, Miao-Qing Zhao, Ye-Jun Qin, Xi-Chao Sun
Summary: The study aims to provide an efficient screening strategy to distinguish a broader spectrum of Lynch syndrome (LS) and its mimics, utilizing a combination of clinical and molecular analyses. This strategy is expected to enhance screening efficiency and management for LS and its mimics.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Article
Oncology
Zahra Mehdipour Namdar, Navid Omidifar, Peyman Arasteh, Majid Akrami, Sedigheh Tahmasebi, Aida Salehi Nobandegani, Sogol Sedighi, Vahid Zangouri, Abdolrasoul Talei
Summary: Frozen section pathology is an effective method for detecting involved sentinel lymph nodes in breast cancer patients, but has limitations in accurately identifying marginal involvement.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Kelsey Danley, Karen Schmitz, Ritu Ghai, Joy S. Sclamberg, Lela E. Buckingham, Kelly Burgess, Timothy M. Kuzel, Lydia Usha
Summary: This case report demonstrates a partial response and long-term remission in a woman with metastatic uterine serous carcinoma and Lynch syndrome due to a germline MSH6 gene mutation, treated with frontline pembrolizumab. The observation suggests a potential significant clinical benefit of checkpoint inhibitors used as single agents early on in the treatment of MMR-deficient/high microsatellite instability/hypermutated uterine cancers in women with Lynch syndrome.
Article
Health Care Sciences & Services
Karen M. Huelsman, Jack B. Basil, Rebecca Sisson, Lindsay R. Lipe, Brett Mahon, David J. Draper
Summary: Lynch syndrome patients with synchronous endometrial and ovarian cancer (SEOC) are rare, and a 39-year-old patient with germline PMS2 mutation was reported in this study. Tumor analysis identified clonality of the two tumors arising from one common site, suggesting potential therapy options.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pathology
Johann Lok, Ka Yu Tse, Elaine Yuen Phin Lee, Richard Wing Cheuk Wong, Ivy Shui Ying Cheng, Alice Ngot Htain Chan, Charlotte Ka Lun Leung, Annie Nga Yin Cheung, Philip Pun Ching Ip
Summary: Frozen section diagnosis of uterine smooth muscle tumors has a high accuracy rate, with most cases examined due to abnormal tumor appearance and intraoperative discovery. Diagnostic errors typically result from stromal and cellular alterations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Pathology
Kyle M. Devins, Robert H. Young, Mariachristina Ghioni, Eike Burandt, Jennifer A. Bennett, Esther Oliva
Summary: Embryonal rhabdomyosarcoma of the uterine cervix is a rare tumor associated with DICER1 mutations. The tumor presents with various clinical features and can be difficult to diagnose. The adenosarcoma staging system is superior to the uterine sarcoma staging system for predicting survival. The tumor has a good prognosis at this site, although some patients may experience local recurrence or extrauterine recurrence.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Pathology
Martin Koebel, Bo Meng, Lien N. Hoang, Noorah Almadani, Xiaodong Li, Robert A. Soslow, C. Blake Gilks, Cheng-Han Lee
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2016)
Article
Oncology
Maria B. Schiavone, Oliver Zivanovic, Qin Zhou, Mario M. Leitao, Douglas A. Levine, Robert A. Soslow, Kaled M. Alektiar, Vicky Makker, Alexia Iasonos, Nadeem R. Abu-Rustum
ANNALS OF SURGICAL ONCOLOGY
(2016)
Review
Pathology
Niamh Conlon, Robert A. Soslow, Rajmohan Murali
JOURNAL OF CLINICAL PATHOLOGY
(2015)
Article
Oncology
Salvatore Piscuoglio, Kathleen A. Burke, Charlotte K. Y. Ng, Anastasios D. Papanastasiou, Felipe C. Geyer, Gabriel S. Macedo, Luciano G. Martelotto, Ino de Bruijn, Maria R. De Filippo, Anne M. Schultheis, Rafael A. Ioris, Douglas A. Levine, Robert A. Soslow, Brian P. Rubin, Jorge S. Reis-Filho, Britta Weigelt
JOURNAL OF PATHOLOGY
(2016)
Letter
Oncology
Xinglei Chai, Susan Domchek, Noah Kauff, Timothy Rebbeck, Jinbo Chen
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2015)
Article
Pathology
Laura Romero-Perez, Pablo Garcia-Sanz, Alba Mota, Susanna Leskela, Marta Hergueta-Redondo, Juan Diaz-Martin, M. Angeles Lopez-Garcia, M. Angeles Castilla, Angel Martinez-Ramirez, Robert A. Soslow, Xavier Matias-Guiu, Gema Moreno-Bueno, Jose Palacios
Article
Pathology
Petar Jelinic, Brooke A. Schlappe, Niamh Conlon, Jill Tseng, Narciso Olvera, Fanny Dao, Jennifer J. Mueller, Yaser Hussein, Robert A. Soslow, Douglas A. Levine
Article
Pathology
Niamh Conlon, Anne M. Schultheis, Salvatore Piscuoglio, Annacarolin. A. Silva, Esther Guerra, Carmen Tornos, Victor E. Reuter, Robert A. Soslow, Robert H. Young, Esther Oliva, Britta Weigelt
Article
Oncology
Jennifer J. Mueller, Marie Holzapfel, Chan H. Han, Kevin Santos, Camille Gunderson, Kathleen Moore, Britt Erickson, Charles A. Leath, Elena Diaz, Christine Walsh, Stephanie L. Wethington, Sheila Z. Dejbakhsh, Richard R. Barakat, Ginger J. Gardner, David M. Hyman, Robert A. Soslow, Mario M. Leitao
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2016)
Article
Obstetrics & Gynecology
Yaser R. Hussein, Russell Broaddus, Britta Weigelt, Douglas A. Levine, Robert A. Soslow
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2016)
Article
Obstetrics & Gynecology
Simona Stolnicu, Claudiu Molnar, Iulia Barsan, Monica Boros, Francisco F. Nogales, Robert A. Soslow
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2016)
Article
Obstetrics & Gynecology
Russell Vang, Douglas A. Levine, Robert A. Soslow, Charles Zaloudek, Ie-Ming Shih, Robert J. Kurman
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2016)
Meeting Abstract
Oncology
Catherine A. Shu, Malcolm C. Pike, Anjali R. Jotwani, Tara M. Friebel, Robert A. Soslow, Douglas A. Levine, Mark E. Robson, Jason A. Konner, Joanne Lorraine Blum, Susan L. Neuhausen, Judy Ellen Garber, Mary Beryl Daly, Claudine Isaacs, Ros A. Eeles, Patricia A. Ganz, Carol Aghajanian, Kenneth Offit, Susan M. Domchek, Timothy R. Rebbeck, Noah D. Kauff
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Meeting Abstract
Oncology
Tara Soumerai, David Michael Hyman, Rajmohan Murali, Ahmet Zehir, Roisin Eilish O'Cearbhaill, Maria E. Arcila, Carol Aghajanian, Robert A. Soslow, David B. Solit, Martee Leigh Hensley
JOURNAL OF CLINICAL ONCOLOGY
(2015)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.
