Article
Endocrinology & Metabolism
Artur Kuchareczko, Janusz Kopczynski, Artur Kowalik, Kinga Hincza-Nowak, Agnieszka Walczyk, Iwona Palyga, Tomasz Trybek, Monika Szymonek, Danuta Gasior-Perczak, Klaudia Gadawska-Juszczyk, Estera Mikina, Izabela Plachta, Agnieszka Suligowska, Agnieszka Plusa, Magdalena Chrapek, Tomasz Lopatynski, Stanislaw Gozdz, Aldona Kowalska
Summary: This study examined the impact of BRAF(V600E) and TERT hotspot mutations on Polish patients with PTMC. Regardless of the presence of these mutations, the overall response to treatment and long-term disease-free survival rates were excellent.
Article
Endocrinology & Metabolism
Tetiana Bogdanova, Serhii Chernyshov, Liudmyla Zurnadzhy, Tatiana I. I. Rogounovitch, Norisato Mitsutake, Mykola Tronko, Masahiro Ito, Michael Bolgov, Sergii Masiuk, Shunichi Yamashita, Vladimir A. A. Saenko
Summary: This study investigated the differences in behavior between radiogenic and sporadic papillary thyroid microcarcinoma (MPTC) and found that radiogenic MPTCs did not exhibit more aggressive clinical and histopathological behavior compared to sporadic tumors. Furthermore, radiogenic MPTCs had lower frequencies of oncocytic changes, nodal disease, and higher rates of complete remission after radioiodine therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yan Lin, Zhao-rong Wu, Yao-ping Shi, Min Ding, Xiao-yin Tang, Yi He, Bo Zhai, Ping Li
Summary: This study evaluates the efficiency, safety, and prognosis of ultrasound-guided percutaneous radiofrequency ablation (RFA) for unifocal papillary thyroid microcarcinomas (PTMCs) with BRAF V600E mutation. The results show that RFA is an effective and safe treatment option for unifocal PTMCs with BRAF V600E mutation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Mingguo Xie, Xiongfei Wang, Jiao Qiao, Jian Zhou, Yuguang Guan, Tianfu Li, Xueling Qi, Guoming Luan
Summary: The study evaluated the clinicopathological features and surgical prognosis of epilepsy-associated glioneuronal tumors (GNT) with CD34 expression and BRAF mutation. The results showed that CD34 expression or BRAF mutation in GNT was not associated with surgical outcomes of seizure control and tumor progression-free survival.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Laura Perez-Fernandez, Julia Sastre, Carles Zafon, Amelia Oleaga, Esmeralda Castelblanco, Ismael Capel, Juan C. Galofre, Sonsoles Guadalix-Iglesias, Antonio De la Vieja, Garcilaso Riesco-Eizaguirre
Summary: Dynamic risk stratification (DRS) is a new system in thyroid cancer that considers treatment response to improve the initial risk of recurrence. In this multicenter study, we validated the DRS system and found that integrating BRAFV600E into DRS does not provide additional benefit.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jing Du, Ruijun Han, Cui Chen, Xiaowei Ma, Yuling Shen, Jun Chen, Fenghua Li
Summary: The combined use of ultrasound, cytology, and BRAF(V600E) mutation analysis is the most efficient and objective method for diagnosing papillary thyroid microcarcinoma (PTMC). The BRAF(V600E) mutation test has the highest sensitivity, specificity, accuracy, and diagnostic value among the three methods.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Federica Vianello, Simona Censi, Sara Watutantrige-Fernando, Susi Barollo, Yi Hang Zhu, Nora Albiger, Loris Bertazza, Jacopo Manso, Sofia Carducci, Clara Benna, Maurizio Iacobone, Francesca Galuppini, Gianmaria Pennelli, Caterina Mian
Summary: Only a minority of cases of differentiated thyroid carcinoma (DTC) have a poor clinical outcome, with distant metastatic DTC having the worst prognosis. Large and small non-metastatic DTC have similar outcomes, but show different molecular patterns. TERT promoter mutations emerged as an independent factor pointing to a poor prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Maria Teresa Sama, Enrico Grosso, Chiara Mele, Sara Laurora, Oriana Monzeglio, Paolo Marzullo, Renzo Boldorini, Paolo Aluffi Valletti, Gianluca Aimaretti, Maria Scatolini, Loredana Pagano
Summary: Despite the generally indolent clinical course and good prognosis of mPTCs, a subset may exhibit potentially aggressive behavior, leading to relapse and metastasis. The most frequently detected mutation in mPTCs is BRAF(V600E), which is associated with unfavorable histopathological features but not directly linked to tumor recurrence and distant metastasis. Further research is needed to explore the specific genetic alterations that could serve as prognostic markers in mPTCs.
Article
Oncology
Joonseon Park, Solji An, Kwangsoon Kim, Ja Seong Bae, Jeong Soo Kim
Summary: BRAF(V600E) positivity is associated with increased aggressiveness of papillary thyroid cancer (PTC). Younger patients with BRAF(V600E)-positive PTC have a higher risk of recurrence compared to older patients.
Article
Endocrinology & Metabolism
Jingjia Cao, Baojin Chen, Xiaolu Zhu, Yaru Sun, Xiao Li, Wei Zhang, Ximing Wang
Summary: This study evaluated the role of the BRAFV600E mutation in the clinical outcomes of PTMC after RAI therapy. The BRAFV600E mutation was found to be associated with multifocality, extrathyroidal invasion, and tumor size in PTMC, but had no significant association with clinical outcomes in patients with intermediate to high recurrence risk.
Article
Multidisciplinary Sciences
Han Luo, Xuyang Xia, Gyeong Dae Kim, Yang Liu, Zhinan Xue, Lingyun Zhang, Yang Shu, Tian Yang, Yan Chen, Shouyue Zhang, Haining Chen, Weihan Zhang, Ruicen Li, Huairong Tang, Birong Dong, Xianghui Fu, Wei Cheng, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Changyang Gong, Yiguo Hu, Jingqiang Zhu, Zhihui Li, Carlos Caulin, Tao Wei, Jihwan Park, Heng Xu
Summary: By utilizing single-cell RNA sequencing, this study delved into the landscape of thyroid cancer at a single-cell level, elucidating the dedifferentiation process and suppressive immune microenvironment. It was found that ATC cells originated from a small subset of PTC cells, with CREB3L1 potentially playing a functional role in ATC development.
Article
Medicine, General & Internal
Yini Zhang, Lidan Liu, Ye Liu, Nan Cao, Lifen Wang, Chengjuan Xing
Summary: This study found that using IHC to detect BRAF V600E mutant protein has high sensitivity but low specificity in diagnosing PTC, and can be used as a preliminary screening method. The mutation rate of BRAF V600E protein in the HT+PTC group was significantly lower than that in the PTC group.
Article
Biochemistry & Molecular Biology
Elisa Bonaldi, Chiara Gargiuli, Loris De Cecco, Arianna Micali, Maria Grazia Rizzetti, Angela Greco, Maria Grazia Borrello, Emanuela Minna
Summary: The study demonstrates that the BRAF inhibitors Vemurafenib and Dabrafenib induce antiproliferative and redifferentiative effects in thyroid cancer cells, while rewiring the MAPK pathway related to RAS signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Jennifer A. Silver, Mariya Bogatchenko, Marc Pusztaszeri, Veronique-Isabelle Forest, Michael P. Hier, Ji Wei Yang, Michael Tamilia, Richard J. Payne
Summary: The study found an association between BRAF V600E mutation and aggressive features in PTMC (<= 1 cm) and small PTC (1-1.5 cm). Determining the molecular status of these thyroid nodules for the presence of BRAF V600E can help guide patient management.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil
Summary: The BRAF(V600E) mutation is associated with the clinicopathological progression of PTMC, leading to more aggressive tumors and higher recurrence risk. Patients with BRAF(V600E) mutations may require earlier interventions, while those with wild-type BRAF(V600E) PTMC can be managed conservatively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Umberto Malapelle, Francesco Pepe, Pasquale Pisapia, Annalisa Altimari, Claudio Bellevicine, Hans Brunnstrom, Rossella Bruno, Reinhard Buttner, Luis Cirnes, Carlos E. De Andrea, Dario de Biase, Catherine Dumur, Kajsa Ericson Lindquist, Gabriella Fontanini, Eugenio Gautiero, David Gentien, Paul Hofman, Veronique Hofman, Antonino Iaccarino, Maria Dolores Lozano, Clara Mayo-de-Las-Casas, Sabine Merkelbach-Bruse, Fabio Pagni, Ruth Roman, Fernando C. Schmitt, Janna Siemanowski, Sinchita Roy-Chowdhuri, Giovanni Tallini, Francesc Tresserra, Sara Vander Borght, Philippe Vielh, Elena Vigliar, Giulia Anna Carmen Vita, Birgit Weynand, Rafael Rosell, Miguel Angel Molina Vila, Giancarlo Troncone
Summary: Gene fusion assays are crucial for personalized treatments of advanced human cancers. This study developed and validated gene fusion reference standards using cell line slides, finding that better results were obtained with Pap staining and amplicon-based assays. Further optimization is required for MGG stained cells and hybridisation-based approaches.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Anna Koot, Paula Soares, Eyal Robenshtok, Laura D. Locati, Christelle de la Fouchardiere, Markus Luster, Massimo Bongiovanni, Rosella Hermens, Petronella Ottevanger, Frans Geenen, Beate Bartes, Harald Rimmele, Cosimo Durante, Els Nieveen-van Dijkum, Peep Stalmeier, Marek Dedecjus, Romana Netea-Maier
Summary: The incidence of differentiated thyroid cancer (DTC) is increasing globally, mainly due to the detection of micro papillary thyroid carcinomas (microPTCs), which often lead to overtreatment without improvement in mortality rate. Less aggressive approaches, such as active surveillance or minimally invasive treatments (MIT), have been suggested as alternatives. Patient participation in decision-making process is crucial. The Endocrine Task Force of the EORTC aims to establish consensus and provide practical suggestions for implementing shared decision making (SDM) based on scientific evidence and patients' needs.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Marco Capezzone, Massimo Tosti Balducci, Eugenia Maria Morabito, Cosimo Durante, Paolo Piacentini, Liborio Torregrossa, Gabriele Materazzi, Giacomo Giubbolini, Virginia Mancini, Maja Rossi, Massimo Alessandri, Alessandra Cartocci
Summary: The incidence of thyroid cancer in Italy, particularly in the southern Tuscany region, is high and could be influenced by environmental heavy metal pollution. The study observed significantly higher incidence rates in Grosseto Province compared to other provinces, especially among male patients.
Article
Biochemistry & Molecular Biology
Antonio De Leo, Daniela Serban, Thais Maloberti, Viviana Sanza, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Federico Chiarucci, Angelo Gianluca Corradini, Andrea Repaci, Alessandra Colapinto, Margherita Nannini, Maria A. Pantaleo, Dario de Biase, Giovanni Tallini
Summary: BRAF non-V600E mutations are uncommon in thyroid carcinoma, typically found in indolent follicular-patterned tumors, but can also be found in tumors with metastatic potential concomitant with other molecular alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Giorgio Grani, Michele Gentili, Federico Siciliano, Domenico Albano, Valentina Zilioli, Silvia Morelli, Efisio Puxeddu, Maria Chiara Zatelli, Irene Gagliardi, Alessandro Piovesan, Alice Nervo, Umberto Crocetti, Michela Massa, Maria Teresa Sama, Chiara Mele, Maurilio Deandrea, Laura Fugazzola, Barbara Puligheddu, Alessandro Antonelli, Ruth Rossetto, Annamaria D'Amore, Graziano Ceresini, Roberto Castello, Erica Solaroli, Marco Centanni, Salvatore Monti, Flavia Magri, Rocco Bruno, Clotilde Sparano, Luciano Pezzullo, Anna Crescenzi, Caterina Mian, Dario Tumino, Andrea Repaci, Maria Grazia Castagna, Vincenzo Triggiani, Tommaso Porcelli, Domenico Meringolo, Laura Locati, Giovanna Spiazzi, Giulia Di Dalmazi, Aris Anagnostopoulos, Stefano Leonardi, Sebastiano Filetti, Cosimo Durante
Summary: Researchers have developed a comprehensive data-driven model to predict recurrent disease in thyroid cancer, utilizing the Italian Thyroid Cancer Observatory database. The decision tree model outperformed the current risk stratification system and can improve the prediction of treatment response. The inclusion of other variables can enhance the accuracy of risk assessment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Roger Chou, Tracy Dana, Sarah E. Mayson, Edmund S. Cibas, Cosimo Durante, Carmen C. Solorzano, Susan J. Mandel, Lisa A. Orloff
Summary: The optimal ultrasound follow-up intervals for cytologically benign thyroid nodules with low to intermediate suspicion patterns and the outcomes of discontinuing ultrasound follow-up are unclear. Only one retrospective cohort study found that there was no significant difference in malignancy rates between >4-year and 1-2-year follow-up intervals. However, longer follow-up intervals were associated with increased nodule growth, repeat biopsies, and thyroidectomies. Further research is needed to clarify the optimal ultrasound follow-up intervals and outcomes of discontinuing follow-up for low to intermediate suspicion cytologically benign thyroid nodules.
Article
Endocrinology & Metabolism
Z. M. Besharat, S. Trocchianesi, A. Verrienti, R. Ciampi, S. Cantara, C. Romei, C. Sabato, T. M. R. Noviello, A. Po, A. Citarella, F. P. Caruso, I. Panariello, F. Gianno, G. Carpino, E. Gaudio, M. Chiacchiarini, L. Masuelli, M. Sponziello, V. Pecce, T. Ramone, F. Maino, F. Dotta, M. Ceccarelli, L. Pezzullo, C. Durante, M. G. Castagna, R. Elisei, E. Ferretti
Summary: The study aimed to identify non-invasive circulating biomarkers in medullary thyroid carcinoma (MTC). By analyzing tissue and plasma extracellular vesicle samples from MTC patients, a set of circulating miRNAs, including miR-26b-5p and miR-451a, were identified as diagnostic biomarkers. These miRNAs showed high expression levels and their expression decreased in disease-free patients during follow-up. The results provide a novel non-invasive tool for the molecular diagnosis of MTC.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
G. Grani, L. Lamartina, T. Montesano, M. Maranghi, S. Filetti, C. Durante, S. Lopatriello
Summary: Ultrasound screening for thyroid cancer is not cost-effective for asymptomatic adults, and there is less consensus on screening for high-risk individuals. This study aimed to estimate the costs of ultrasound screening for individuals with a family history of thyroid cancer.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Dario de Biase, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Marco Grillini, Martina Ruscelli, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Daniela Turchetti, Andrea Galuppi, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Antonio De Leo
Summary: This study compares the new ESGO/ESTRO/ESP risk stratification system with the previous 2016 recommendations for endometrial carcinoma patients. The results show that the new system provides more accurate identification of low-risk and high-risk patients, potentially allowing a more specific selection of patients for post-operative adjuvant therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Martina Ruscelli, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Giulia Querzoli, Marco Grillini, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Alessia Costantino, Riccardo Ciudino, Matteo Errani, Alessia Papapietro, Sara Coluccelli, Daniela Turchetti, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Emanuela D'Angelo, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Dario de Biase, Antonio De Leo
Summary: This study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice of endometrial carcinoma (EC). It found that molecular classes and risk groups were correlated with disease-free survival. The study supports the prognostic importance of EC molecular classification and the essential role of histopathologic assessment in patients' management.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Chiara Scorziello, Cosimo Durante, Marco Biffoni, Maria Carola Borcea, Fabrizio Consorti, Angelo Laca, Rossella Melcarne, Luca Ventrone, Laura Giacomelli
Summary: We investigated the predictive value of thyroid nodule size for malignancy and the consequences of following the ACR guidelines for FNAB. A retrospective observational study on 86 patients who underwent surgery was conducted. Sub-categories were created based on size thresholds for FNAB. The study did not find a significant difference in malignancy prediction between the sub-categories, suggesting that the utility of size thresholds in standardized thyroid work-up may be less clear than suggested by the ACR guidelines.
Article
Medicine, General & Internal
Chiara Scorziello, Maria Carola Borcea, Marco Biffoni, Angelina Pernazza, Francesca Arienzo, Rossella Melcarne, Luca Ventrone, Angelo Laca, Giorgio Grani, Cosimo Durante, Fabrizio Consorti, Laura Giacomelli
Summary: Incidental sonographic discovery of thyroid nodules is common in clinical practice. Suspicious cervical lymph nodes may be detected in patients with cytological benign thyroid nodules. We discuss a case of cervical lymph node metastasis from a lung carcinoma in a 65-year-old asymptomatic male smoker. Differentiating metastatic lesions in the thyroid gland can be challenging, especially when evaluating lesions in the region and when fine needle aspiration biopsy yields negative results or cytological evaluations are inconsistent with thyroid cytological findings and sonographic features. Detecting lung cancer at earlier stages remains a clinical challenge, as it is the leading cause of cancer mortality worldwide.
CLINICAL CASE REPORTS
(2023)
Article
Endocrinology & Metabolism
Jaume Capdevila, Desiree' Deandreis, Cosimo Durante, Sophie Leboulleux, Markus Luster, Romana Netea-Maier, Kate Newbold, Susanne Singer, Gerasimos P. Sykiotis, Beate Bartes, Kate Farnell, Laura Deborah Locati
Summary: It is essential to provide guidance for the management of RAI-R DTC patients with systemic therapies, and especially lenvatinib, since compliance and adherence to treatment are fundamental to achieve the best outcomes. The therapeutic landscape in RAI-R DTC is evolving, with new targeted therapies, immunotherapy, etc., lenvatinib is expected to remain a first-line treatment and mainstay of therapy for several years in the vast majority of patients and settings.
EUROPEAN THYROID JOURNAL
(2023)
Article
Endocrinology & Metabolism
Cosimo Durante, Laszlo Hegedues, Agnieszka Czarniecka, Ralf Paschke, Gilles Russ, Fernando Schmitt, Paula Soares, Tamas Solymosi, Enrico Papini
Summary: With the widespread use of imaging techniques, an increasing number of thyroid nodules are discovered. Most are benign and do not require treatment, while small intrathyroidal neoplasms can be safely managed conservatively. Guidelines are needed to provide a cost-effective and patient-centered approach to managing this prevalent condition. The present guidelines aim to provide a clinical practice guide for the initial workup and management of thyroid nodules in adults, and are not intended for the management of thyroid malignancy.
EUROPEAN THYROID JOURNAL
(2023)
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.