Article
Pharmacology & Pharmacy
Ying Liu, Yiqi Wang, Xing Zhang, Yang Jiao, Lian Duan, Lingling Dai, Hong Yan
Summary: This study found that chronic exposure to ACR can lead to neuronal loss and motor dysfunction, potentially through the NLRP3 inflammasome-mediated neuroinflammation mechanism.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Clinical Neurology
Qiong Liu, Juan Chen, Jin Xue, Xun Zhou, Yun Tian, Qiao Xiao, Wen Huang, Yongcheng Pan, Xiaoxia Zhou, Jian Li, Yuwen Zhao, Hongxu Pan, Yige Wang, Runcheng He, Yaqin Xiang, Tian Tu, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Lu Shen, Ranhui Duan, Beisha Tang, Zhenhua Liu
Summary: This study demonstrates the association between GGC repeat expansions within NOTCH2NLC and the pathogenesis of Parkinson's disease, leading to degeneration of nigral dopaminergic neurons.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Xin Gong, Mengyi Huang, Lei Chen
Summary: This study aims to investigate the effect and mechanism of miR-132-3p in regulating neuroinflammation and dopaminergic neuron degeneration in Parkinson's disease (PD). The results showed elevated expression of miR-132-3p and decreased expression of GLRX in PD patients and cell models. Overexpression of miR-132-3p induced activation of microglial cells, which could be reversed by GLRX overexpression.
Review
Cell Biology
Giulia Guidotti, Chiara Scarlata, Liliana Brambilla, Daniela Rossi
Summary: The involvement of TNF alpha in ALS is controversial, with studies suggesting both protective and detrimental functions depending on the type of TNF alpha receptor activated. Understanding the impact of this cytokine on disease progression may lead to the development of effective therapies targeting the protective roles of TNF alpha and minimizing the detrimental effects.
Article
Biochemistry & Molecular Biology
Cong Liu, Wenjuan Wang, Hao Li, Jiangang Liu, Peng Zhang, Yong Cheng, Xiaoyan Qin, Yang Hu, Yun Wei
Summary: Parkinson's disease is the second most common neurodegenerative disease, with oxidative stress and apoptosis playing important roles in the disease process. Isoquercitrin, a natural compound found in apple pomace, has anti-oxidation, anti-aging, and anti-inflammation properties. Research showed that isoquercitrin has neuroprotective effects on MPTP-induced acute mouse models of Parkinson's disease, improving animal behaviors, mitigating dopamine neuron loss, and inhibiting oxidative stress.
Article
Pharmacology & Pharmacy
Qinghui Lan, Peiqing Guan, Chunzheng Huang, Shile Huang, Peiling Zhou, Changzheng Zhang
Summary: This study demonstrated that arecoline significantly increased the firing rate of dopaminergic neurons and induced burst firing. This may contribute to areca nut dependency and provide a potential target for cessation therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Xuan Du, Rosana Penalva, Karis Little, Adrien Kissenpfennig, Mei Chen, Heping Xu
Summary: The LysMCre-Socs3(fl/fl)Cx3cr1(gfp/gfp) DKO mice showed primary microglial dysfunction and age-related retinal microgliopathy, characterized by increased microglial activation and degeneration of retinal neurons and RPE. The microglia from DKO mice exhibited higher phagocytic activity and pro-inflammatory cytokine production compared to microglia from Socs3(fl/fl) mice, leading to reduced cone photoreceptor survival.
MOLECULAR NEURODEGENERATION
(2021)
Article
Biochemistry & Molecular Biology
Mikhail Melnikov, Mikhail Pashenkov, Alexey Boyko
Summary: Dopamine functions as a neurotransmitter in the central nervous system and has modulatory effects on both innate and adaptive immune system cells. It plays a critical role in regulating neuroinflammation in multiple sclerosis, and holds therapeutic potential for MS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jason P. Fernandes, William G. Branton, Eric A. Cohen, Gerrit Koopman, Ivanela Kondova, Benjamin B. Gelman, Christopher Power
Summary: Despite effective antiretroviral therapies, a significant proportion of treated HIV infection cases develop a neurodegenerative syndrome called HIV-associated neurocognitive disorder (HAND). This study investigates the mechanisms underlying neuronal damage and death in HAND and identifies a novel mechanism by which HIV triggers pyroptotic death in neurons. Targeting this mechanism could offer new diagnostic and therapeutic strategies for HAND and other neurodegenerative disorders.
Article
Food Science & Technology
Yanrong Ren, Shiwen Hu, Hongzheng Pu, Ying Zhou, Mingzhu Jiang, Yuanyuan Li, Chaofang Deng, Jie Gao, Minxuan Xu, Chenxu Ge
Summary: The study explored the regulatory potential of Jug in treating depression in vivo and in vitro, showing that Jug has neuroprotective and anti-inflammatory effects by improving AMPK activation, which may be a novel therapeutic strategy for depression treatment.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Simonini, Elisabetta Zucchi, Roberta Bedin, Ilaria Martinelli, Giulia Gianferrari, Nicola Fini, Gianni Soraru, Rocco Liguori, Veria Vacchiano, Jessica Mandrioli
Summary: The study found that CSF pNfH is significantly higher in classic and UMNp-ALS patients, and can differentiate them from UMN diseases with a better prognosis such as PLS and hSP. CSF pNfH independently predicted survival in UMN patients and classic/bulbar ALS, while in UMNp-ALS patients, the progression rate and presence of multifocal fasciculations were independent prognostic factors.
Review
Immunology
Rahul M. Dhodapkar, Diego Martell, Brian P. Hafler
Summary: Age-related macular degeneration (AMD) is a neurodegenerative disorder that leads to irreversible vision loss worldwide. Microglia-mediated neuroinflammation is identified as a key driver of neural damage in AMD, presenting potential therapeutic targets.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Biology
Eva M. Szego, Laura Malz, Nadine Bernhardt, Angela Roesen-Wolff, Bjoern H. Falkenburger, Hella Luksch
Summary: This study demonstrates that chronic activation of the STING pathway is sufficient to cause degeneration of dopaminergic neurons, which could be significant in Parkinson's disease and other neurodegenerative diseases.
Article
Multidisciplinary Sciences
Simone Bido, Sharon Muggeo, Luca Massimino, Matteo Jacopo Marzi, Serena Gea Giannelli, Elena Melacini, Melania Nannoni, Diana Gambare, Edoardo Bellini, Gabriele Ordazzo, Greta Rossi, Camilla Maffezzini, Angelo Iannelli, Mirko Luoni, Marco Bagicaluppi, Silvia Gregori, Francesco Nicassio, Vania Broccoli
Summary: Recent findings suggest that accumulation of alpha-synuclein in microglial cells can induce selective degeneration of dopaminergic neurons, leading to the development of a reactive, pro-inflammatory state and phagocytic exhaustion in microglia.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Joseph T. Ortega, Tanu Parmar, Beata Jastrzebska
Summary: The neuropeptide GALR3 is expressed in the nervous system and retina, involved in modulation of immune and inflammatory responses. It plays a crucial role in retinal pathologies triggered by bright light and gene mutations. Inhibition or depletion of GALR3 can improve retinal health and reduce stress response processes.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Sarah Nicolas, Ciaran S. O. Leime, Alan E. Hoban, Cara M. Hueston, John F. Cryan, Yvonne M. Nolan
Summary: Adolescent consumption of a cafeteria diet affects metabolic and inflammatory states in rats, but does not have lasting effects on behavior in adulthood.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Cassie Fives, Mutahira Lone, Yvonne M. Nolan
Summary: The study revealed that first-year speech and language therapy students highly value the importance of anatomy for clinical practice, primarily learn anatomy through attending lectures, and generally experience significant worry about exams. Additionally, there is a significant relationship between students' motivation to learn anatomy and their mental well-being.
Article
Psychology, Developmental
S. Casey, M. Carter, A. M. Looney, V Livingstone, G. Moloney, G. W. O'Keeffe, R. S. Taylor, L. C. Kenny, F. P. McCarthy, L. M. E. McCowan, J. M. D. Thompson, D. M. Murray
Summary: Research suggests a link between maternal immune dysregulation and autism spectrum disorder, with evidence showing that downregulation of IL-17A concentrations in cases may play a role in fetal neurodevelopment. This adds to the growing understanding of the potential impact of maternal immune regulation on offspring neurodevelopment.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Review
Education, Scientific Disciplines
Audrey M. K. Dempsey, Mutahira Lone, Yvonne M. Nolan, Eithne Hunt
Summary: This scoping review found that Universal Design for Learning (UDL) has not been formally applied in healthcare education, but there are teaching methods in anatomy curricula that align with UDL. Further research is needed regarding the impact of UDL on student motivation to learn anatomy in medical, dental, OT and SLT programs.
ANATOMICAL SCIENCES EDUCATION
(2023)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Pharmacology & Pharmacy
Clarissa A. Pisano, Daniela Mercatelli, Martina Mazzocchi, Alberto Brugnoli, Ilaria Morella, Stefania Fasano, Nurulain T. Zaveri, Riccardo Brambilla, Gerard W. O'Keeffe, Richard R. Neubig, Michele Morari
Summary: The study indicates that RGS4 physiologically inhibits NOP receptor signaling and the chemical probe CCG-203920 can enhance NOP responses and improve the antidyskinetic potential of NOP receptor agonists.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Jayanth Anantha, Susan R. Goulding, Eszter Tuboly, Adam G. O'Mahony, Gerard M. Moloney, Gareth Lomansey, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: Parkinson's disease is a neurodegenerative disease characterized by the progressive degeneration of midbrain dopaminergic neurons and axonal degeneration. Research suggests that the neurotrophic factor NME1 may have potential as a therapeutic agent for axonal protection in PD, enhancing mitochondrial function and promoting neurite growth in cell models.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Erin McCarthy, Aaron Barron, Noelia Morales-Prieto, Martina Mazzocchi, Cathal M. McCarthy, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The study suggests a potential therapeutic target for Parkinson's disease in ZNHIT1, which can protect against dopaminergic degeneration and mitochondrial dysfunction induced by alpha-synuclein. Overexpression of ZNHIT1 increases cellular ATP synthesis and prevents impairments in mitochondrial function caused by alpha-synuclein.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pediatrics
Louise Kelly, Peter Barrett, Fergus P. McCarthy, Gerard W. O'Keeffe, Gillian M. Maher, Ali S. Khashan
Summary: This study utilized data from the UK Millennium Cohort Study to investigate the association between hypertensive disorders of pregnancy (HDP) and the risk of asthma in children before the age of seven. The results showed that HDP was associated with an increased risk of asthma, particularly in children born preterm or small for gestational age (SGA).
PEDIATRIC RESEARCH
(2022)
Article
Anatomy & Morphology
Audrey M. K. Dempsey, Eithne Hunt, Mutahira Lone, Yvonne M. Nolan
Summary: There is an increasing need to enhance student engagement in anatomy education. This study aims to assess the awareness and implementation of Universal Design for Learning (UDL) in anatomy curricula in the Republic of Ireland (ROI) and United Kingdom (UK). The majority of participants were unaware of UDL but had unknowingly incorporated elements of UDL in their curriculum design.
Article
Medicine, General & Internal
Danielle Dunk, Philip Mulryan, Sean Affonso, Gerard W. O'Keeffe, Majella O'Keeffe, Aideen M. Sullivan
Summary: This study investigated the dietary intake and quality, sleep, and quality of life in people with Parkinson's disease (PD) and found that while the intake of carbohydrates, protein, fruits, and vegetables was higher than the general population, the overall diet quality was low.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Lucy M. Collins, Rachel Roberts, Hannah Cleary, James Diskin, Donna Kitt, Ingrid Van Bommel-Rutgers, Bouwien C. M. Smits-Engelsman, Erin K. Crowley, Aideen M. Sullivan
Summary: People with Parkinson's disease often experience deteriorating handwriting. A 6-week online training programme was found to improve the handwriting of Parkinson's patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Letter
Clinical Neurology
Conor Giles Doran, Fionnuala Wilson, Susan R. Goulding, Martina Mazzocchi, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
MOVEMENT DISORDERS
(2023)
