Article
Chemistry, Physical
Mehdi Yoosefian, Batool Tajaddini, Saeid Ahmadzadeh, Maryam Zeraati-Moghani, Zahra Pakdin-Parizi
Summary: Drinking excessive alcohol can cause chronic diseases and serious problems such as heart disease, high blood pressure, stroke, digestive problems, and liver disease. A molecular dynamics simulation study found that ethanol blocks calcium channels and interferes with calcium ion passage. Furthermore, calcium ions have a greater tendency to interact with residues inside the protein channel in the presence of ethanol.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Plant Sciences
Daniela M. L. de Andrade, Mikaelle C. Correia, Matheus G. de Oliveira, Eder S. A. Santos, Bruno J. Neves, Jose R. de Paula, Matheus L. Rocha
Summary: Hydroalcoholic extract of Hydrocotyle umbellata L. induces relaxation of arterial vessels, possibly by blocking calcium influx.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
G. M. Archana, R. C. Arunkumar, R. V. Omkumar
Summary: This study reports the presence of L-type VGCC subunit proteins in HEK-293 cells and develops simple methods for its assay. The activity of L-VGCC in HEK-293 cells can be detected through endogenous expression, eliminating the need for transfection. Different experimental methods were used to detect the activity, and the antagonist nifedipine was found to block the activity. These findings offer commercially viable assays for drug screening.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Isara Phiwchai, Titipun Thongtem, Somchai Thongtem, Chalermchai Pilapong
Summary: The study demonstrated that labile iron promotes cell proliferation, growth, and migration in liver cancer cells by influencing cell morphology and cell cycle. The role of the L-type calcium channel in iron uptake highlights a new mechanism for iron-mediated cancer cell growth. This research provides new insights into the diagnosis and treatment of liver cancer.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Multidisciplinary Sciences
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Summary: CaV1.2 channels in the heart are affected by angiotensin II, a therapeutic target of heart failure drugs and regulator of blood pressure. Angiotensin II causes a decrease in PIP2, which leads to the suppression of CaV1.2 currents. This study found that PIP2 depletion destabilizes CaV1.2 channels and reduces their expression and function. The results suggest that PIP2 plays a crucial role in maintaining cardiac excitability and that angiotensin II-induced PIP2 depletion impairs excitation-contraction coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Chelsea A. Crossley, Vishaal Rajani, Qi Yuan
Summary: Calcium plays a crucial role in various cellular processes and signaling pathways in the human body. L-type calcium channels (LTCCs), such as voltage-gated calcium channels, are essential for neurotransmitter release, synaptic integration, and plasticity in the nervous system. Dysfunction of LTCCs has been implicated in aging and Alzheimer's Disease (AD), making them a promising target for AD treatment. However, the mechanisms by which LTCCs contribute to AD are still not fully understood due to their complexity. This review provides an overview of the structure, function, and modulation of LTCCs, highlighting the potential of targeting molecular pathways that up-regulate LTCCs as a more effective approach in AD, considering the diverse physiological functions of LTCCs and the limited success of LTCC blockers in clinical studies.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Chelsea A. Crossley, Vishaal Rajani, Qi Yuan
Summary: Calcium is essential for various signaling pathways and cellular processes in the human body. L-type calcium channels (LTCCs) play a critical role in the nervous system, mediating neurotransmitter release, synaptic integration, and plasticity. Dysfunction of LTCCs has been linked to aging and Alzheimer's Disease (AD), making them a potential target for AD treatment. However, the mechanisms by which LTCCs contribute to AD are still unclear. This review provides an overview of the structure, function, and modulation of LTCCs, suggesting that targeting molecular pathways that up-regulate LTCCs may be a more promising approach in AD.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Cell & Tissue Engineering
Jinghua Piao, Susan Zabierowski, Brittany N. Dubose, Ellen J. Hill, Monalisa Navare, Nidia Claros, Siera Rosen, Kiran Ramnarine, Callie Horn, Craig Fredrickson, Karen Wong, Brent Safford, Sonja Kriks, Abderrahman El Maarouf, Urs Rutishauser, Claire Henchcliffe, Yongzeng Wang, Isabelle Riviere, Shannon Mann, Vladimir Bermudez, Stefan Irion, Lorenz Studer, Mark Tomishima, Viviane Tabar
Summary: The study successfully generated midbrain dopamine neurons from human embryonic stem cells and conducted extensive tests on animals to demonstrate the efficacy and safety of the cell product intended for potential human use, paving the way for future clinical trials.
Article
Neurosciences
Jessica L. Wickline, Sabrina Smith, Riley Shin, Kristian Odfalk, Jesse Sanchez, Martin Javors, Brett Ginsburg, Sarah C. Hopp
Summary: Epidemiological studies suggest that L-type calcium channel antagonists may reduce the incidence of age-associated neurodegenerative diseases, including Alzheimer's disease. However, the protective mechanism of LTCC antagonists is unknown.
Review
Physiology
Sahil Zaveri, Ujala Srivastava, Yongxia Sarah Qu, Mohamed Chahine, Mohamed Boutjdir
Summary: Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes, and dysfunctional Ca2+ regulation can lead to altered contraction force and cardiac arrhythmias. The entry of Ca2+ into cardiomyocytes is mainly mediated by L-type Ca2+ channels, with Ca(v)1.3 being implicated in sinoatrial and atrioventricular node dysfunction as well as atrial fibrillation. Understanding the functional and molecular pathways of Ca(v)1.3 in the heart may help develop targeted therapeutic interventions for these arrhythmias.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xia Yao, Shuai Gao, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, Nieng Yan
Summary: The study reveals the molecular basis for the physical and pharmacodynamic interaction of sofosbuvir and amiodarone on the scaffold of Cav channels.
Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Omur Gulsum Deniz, Ahlam Said Abi Issa, Azim Ullah Shamsul Islam, Naheed Amir, Saeed Tariq Minhas, Nather Madjid, Fatima Khelifi-Touhami, Suleyman Kaplan, Abdu Adem
Summary: The development of animal models to study cell death in the brain is a delicate task. One of the models, that was discovered in the late eighties, is the induction of neurodegeneration through glucocorticoid withdrawal by adrenalectomy in albino rats. In this study, the impact of short-term adrenalectomy on hippocampal neuronal populations in Wistar rats was investigated using stereological technique and ultrastructural examination. The levels of insulin-like growth factor-1 (IGF-1) and beta-nerve growth factor (beta-NGF) were measured to understand the underlying mechanisms of degeneration in these neurons. The cognitive behavior of Wistar rats after short-term adrenalectomy was also examined.
Article
Biochemistry & Molecular Biology
Kuruba Manohar, Rishikesh Kumar Gupta, Parth Gupta, Debasmita Saha, Suman Gare, Rahuldeb Sarkar, Ashish Misra, Lopamudra Giri
Summary: This study establishes a hypoxia model based on A549 cells induced by low oxygen, testing the protective effect of the calcium channel blocker nifedipine. The findings demonstrate that nifedipine can protect cells exposed to hypoxia by reducing cytosolic calcium, mitochondrial calcium, and ROS generation. The study proposes a framework for quantitatively analyzing mitochondrial calcium and ROS levels using 3D imaging, providing insights into potential molecular targets and suggesting the evaluation of nifedipine's therapeutic value in COVID-19 trials.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bryana M. Levitan, Brooke M. Ahern, Ajoy Aloysius, Laura Brown, Yuan Wen, Douglas A. Andres, Jonathan Satin
Summary: Recent studies have identified Rad as playing a central role in modulation of LTCC by β-adrenergic receptor signaling. Deletion of Rad had no significant effect on heart rate variability.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Obstetrics & Gynecology
Nuriye Buyukkayaci Duman, Oguzhan Ozcan, M. Omer Bostanci
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2015)
Article
Biochemistry & Molecular Biology
Oguzhan Ozcan, M. Omer Bostanci, Guner Cicek, Faruk Yamaner
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Anesthesiology
Fatma Ulger, Ayhan Bozkurt, S. Sirri Bilge, Fatih Ilkaya, Ahmet Dilek, M. Oemer Bostanci, Engin Ciftcioglu, Fuat Guldogus
ANESTHESIA AND ANALGESIA
(2009)
Article
Neurosciences
M. Omer Bostanci, Faruk Bagirici
BRAIN RESEARCH BULLETIN
(2008)
Article
Cell Biology
M. Oemer Bostanci, Orhan Bas, Faruk Bagirici
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2010)
Article
Neurosciences
M. Oemer Bostanci, Faruk Bagirici
Article
Toxicology
M. Omer Bostanci, Faruk Bagirici, Orhan Bas
TOXICOLOGY MECHANISMS AND METHODS
(2008)
Article
Medicine, Research & Experimental
Fatih Sefil, Aliye E. Arik, Meryem D. Acar, Mehmet O. Bostanci, Faruk Bagirici, Ramazan Kozan
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2015)
Article
Medicine, General & Internal
M. Fatih Gokce, Faruk Bagirici, Serif Demir, M. Omer Bostanci, Aysel Guven
TURKISH JOURNAL OF MEDICAL SCIENCES
(2009)
Article
Medicine, General & Internal
Ramazan Kozan, M. Oemer Bostanci, Tuncer Nacar, Ali Aslan, Faruk Bagirici
TURKISH JOURNAL OF MEDICAL SCIENCES
(2009)
Article
Cell Biology
M. Omer Bostanci, Faruk Bagirici
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2007)
Article
Clinical Neurology
M. Oemer Bostanci, Faruk Bagirici
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2007)
Article
Neurosciences
M. Omer Bostanci, Faruk Bagirici
Article
Neurosciences
Sefa Gulturk, Ramazan Kozan, M. Omer Bostanci, Fatih Sefil, Faruk Bagirici
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2008)