Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 118, Issue 12, Pages 1725-1747Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207450802174449
Keywords
Corticosterone; degeneration; glucocorticoid; illumination; photoreceptor; retina
Categories
Funding
- University of Buenos Aires
- National Research Council
Ask authors/readers for more resources
Continuous illumination (CI) induces an oxidative stress of the retina which is involved in light-induced retinal degeneration (LIRD). As the increase of glucocorticoids (GC) could also collaborate in the damage, adrenalectomized (ADX) and sham-operated rats (control, CTL) were submitted to CI, and their eyes were studied at light and electron microscopic levels. After CI, ADX retinas were significantly thicker than CTL retinas. Retinal alterations appeared earlier and were severer in CTL than in ADX retinas. Corticosterone levels increased gradually in the sera of CTL rats along CI. These results suggest that adrenalectomy attenuates LIRD, supporting the hypothesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available