Article
Clinical Neurology
Yu-Ting Hu, Xi-Wen Hu, Jin-Fang Han, Jian-Feng Zhang, Ying-Ying Wang, Annemarie Wolff, Sara Tremblay, Dusan Hirjak, Zhong-Lin Tan, Georg Northoff
Summary: This study compared the therapeutic efficacy of rTMS at the left motor cortex (lMC) and left dorsolateral prefrontal cortex (lDLPFC) in MDD patients. The results showed no significant difference in treatment outcomes and tolerability between the two groups. The findings suggest that lMC can be a potential and easily accessible rTMS target.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Multidisciplinary Sciences
Yuanfeng Sun, Fei Lei, Ke Zou, Zhong Zheng
Summary: This study aims to explore changes in depression and pain for major depressive disorder (MDD) patients with somatic pain after repetitive transcranial magnetic stimulation (rTMS) using the event-related potentials (ERPs) technique. The results showed that combined therapy with rTMS and antidepressants can rapidly improve symptoms in patients with somatic pain, especially for anxiety and pain.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Yosuke Koshikawa, Keiichiro Nishida, Tomonari Yamane, Masafumi Yoshimura, Ai Onohara, Satsuki Ueda, Ryouhei Ishii, Toshihiko Kinoshita, Yosuke Morishima
Summary: This study aimed to investigate the subcomponents of cognitive inflexibility in major depressive disorder (MDD) and examine the effects of transcranial direct current stimulation (tDCS) on the prefrontal cortex. The results revealed that MDD patients showed increased behavioral cost in task switching, but comparable proactive interference cost to healthy controls. Additionally, anodal tDCS on the dorsomedial prefrontal cortex (DMPFC) improved the response time compared to anodal tDCS on the dorsolateral prefrontal cortex (DLPFC) in MDD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Chun-Hung Chang, Chieh-Yu Liu, Shaw-Ji Chen, Hsin-Chi Tsai
Summary: This case report presents a 25-year-old woman with comorbid PTSD and depression, whose symptoms improved significantly after receiving accelerated theta-burst stimulation (TBS) on the bilateral dorsolateral prefrontal cortex (DLPFC). The patient showed more improvement in depression symptoms than in PTSD symptoms. Further trials are needed to investigate the effectiveness and safety of accelerated TBS for patients with complex PTSD and depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Zenas C. C. Chao, Daniel G. G. Dillon, Yi-Hung Liu, Elyssa M. M. Barrick, Chien-Te Wu
Summary: This study reveals altered coordination between two functional networks in MDD, and suggests that weak suppression of the task-negative alpha-band parietal network contributes to blunted positive emotional responses in adults with depression.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2022)
Article
Clinical Neurology
Che-Sheng Chu, Cheng-Ta Li, Andre R. Brunoni, Fu-Chi Yang, Ping-Tao Tseng, Yu-Kang Tu, Brendon Stubbs, Andre F. Carvalho, Trevor Thompson, Tarek K. Rajji, Ta-Chuan Yeh, Chia-Kuang Tsai, Tien-Yu Chen, Dian-Jeng Li, Chih-Wei Hsu, Yi-Cheng Wu, Chia-Ling Yu, Chih-Sung Liang
Summary: This study compared the cognitive effects and acceptability of rTMS and tDCS in patients with AD or MCI, finding that HFrTMS is more effective for improving global cognition and individuals with AD may respond better to rTMS and tDCS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Psychiatry
Vahid Nejati, Maryam Majidinezhad, Michael Nitsche
Summary: This study suggests that stimulation over the left dlPFC and right vmPFC can improve emotion regulation, interference control, and working memory performance in women with MDD. Moreover, the emotional valence of stimuli and the impact of stimulation on interference control in MDD are also relevant factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Theresa Herrmann, Carina Koeppel, Jennifer Linn, Ilona Croy, Thomas Hummel
Summary: Depression is associated with reduced olfactory function, potentially due to decreased olfactory bulb volume or weakened functioning of higher cortical areas. By conducting an experiment on 21 patients with Major Depressive Disorder and 21 healthy controls, researchers found that while odor presentation activated primary olfactory areas in both groups, secondary olfactory areas were significantly less activated in depressed individuals. The two groups did not differ in olfactory bulb volume. These findings suggest altered olfactory processing in regions related to sensory integration and attention allocation in depressed patients, potentially caused by difficulties in cognitive processing.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Deniz Yuruk, Can Ozger, Juan F. Garzon, Jarrod M. Leffler, Julia Shekunov, Jennifer L. Vande Voort, Michael J. Zaccariello, Paul A. Nakonezny, Paul E. Croarkin
Summary: This study is a randomized, double-blind, sham-controlled trial of sequential bilateral accelerated theta burst stimulation (aTBS) for treating suicidal ideation in adolescents with major depressive disorder (MDD). Three sessions are administered daily for 10 days, and the effects of the treatment on biomarkers related to suicidal ideation will be examined.
Article
Clinical Neurology
Greg C. Bristow, Tory Eisenlohr-Moul, Krista Lotesto, Monsheel S. Sodhi
Summary: This study found gender differences in the transcription of monoaminergic genes in the DLPFC in MDD patients, indicating that abnormalities in the expression of monoaminergic genes may contribute to alterations in DLPFC activity observed in major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Maimu Alissa Rehbein, Thomas Kroker, Constantin Winker, Lena Ziehfreund, Anna Reschke, Jens Boelte, Miroslaw Wyczesany, Kati Roesmann, Ida Wessing, Markus Junghoefer
Summary: In this study, the causal role of the ventromedial prefrontal cortex (vmPFC) in reward prediction, processing, and reward prediction error (RPE) signaling was investigated by modulating vmPFC excitability using transcranial Direct Current Stimulation (tDCS). The results showed that vmPFC excitation led to increased activation and anticipation of negative outcomes, enhanced pleasantness and anticipation of positive outcomes, improved behavioral flexibility after losses and unpredictable outcomes, and increased pupil dilations.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Computer Science, Cybernetics
Maximilian A. Friehs, Martin Dechant, Sarah Vedress, Christian Frings, Regan L. Mandryk
Summary: As digital gaming becomes more competitive, players are looking for ways to enhance their performance, including using non-invasive brain stimulation techniques like tDCS. While tDCS has shown to improve cognitive processing, there is limited scientific evidence on whether it can improve performance in visually complex and attentionally demanding digital games.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES
(2021)
Article
Psychology, Biological
Fiorenzo Moscatelli, Vincenzo Monda, Pierpaolo Limone, Gabriella Marsala, Nicola Mancini, Marcellino Monda, Antonietta Messina, Antonella De Maria, Alessia Scarinci, Antonietta Monda, Rita Polito, Giovanni Messina
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) can improve selective attention response in volleyball players and also affect cortical excitability.
PHYSIOLOGY & BEHAVIOR
(2023)
Review
Psychology, Clinical
Mauro Pettorruso, Andrea Miuli, Chiara Di Natale, Chiara Montemitro, Francesca Zoratto, Luisa De Risio, Giacomo d'Andrea, Pinhas N. Dannon, Giovanni Martinotti, Massimo di Giannantonio
Summary: Although heterogeneous in protocols and parameters, results from tDCS and TMS studies indicate that the stimulation (instead of inhibition) of prefrontal regions could be beneficial to combat dysfunctional gambling-related decision processes. Further research is needed to investigate connectivity changes and laterality issues of NIBS application in GD.
ADDICTIVE BEHAVIORS
(2021)
Article
Psychiatry
Haijing Huang, Yiming Chen, Shuqi Kong, Mengke Zhang, Chenglin Wu, Dongbin Lyu, Qinte Huang, Weichieh Yang, Shuxiang Shi, Nuoshi Qian, Fan Wang, Zheyi Wei, Shentse Chen, Ni Zhou, Jianming Zhang, Wu Hong
Summary: Transcranial direct current stimulation (tDCS) may be an effective treatment for depression, particularly in improving cognitive function in patients with depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Education & Educational Research
Andrew H. Kemp, Zoe Fisher
Summary: Psychological science is going through a period of transformation, with a crisis in confidence leading to a neglect of single-subject research designs. It is suggested to teach single-case designs in undergraduate education to enable students to draw objective conclusions.
TEACHING OF PSYCHOLOGY
(2023)
Article
Clinical Neurology
Rodolfo Furlan Damiano, Deusdedit Brandao Neto, Joao Vitor Ribeiro Oliveira, Jonatas Magalhaes Santos, Julia Vallin Rodrigues Alves, Bruno F. Guedes, Ricardo Nitrini, Adriana Ladeira de Araujo, Melaine Oliveira, Andre R. Brunoni, Richard Louis Voegels, Ricardo Ferreira Bento, Geraldo Busatto, Euripedes Constantino Miguel, Orestes V. Forlenza, Fabio de Rezende Pinna
Summary: Preliminary methodologically limited studies suggest an association between chemosensory impairments and neuropsychiatric symptoms in post-COVID-19 patients. This study aims to evaluate the relationship between chemosensory dysfunction and neuropsychiatric impairments in a well-characterized sample of post-COVID-19 patients. The findings indicate a positive association between chemosensory abnormalities and cognitive dysfunction in these patients.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Claudia K. Suemoto, Ronaldo B. Santos, Soraya Giatti, Aline N. Aielo, Wagner A. Silva, Barbara K. Parise, Lorenna F. Cunha, Silvana P. Souza, Rosane H. Griep, Andre R. Brunoni, Paulo A. Lotufo, Isabela M. Bensenor, Luciano F. Drager
Summary: Sleep disturbances have a potential impact on cognitive performance, and the association between insomnia and cognitive function is modified by OSA and oxygen saturation.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Psychiatry
Rebeca Pelosof, Leonardo A. dos Santos, Luis C. Farhat, Wagner F. Gattaz, Leda Talib, Andre R. Brunoni
Summary: This updated review found an increase in BDNF levels after ECT treatment for depression. However, there was significant heterogeneity and limited sample sizes in the studies, indicating the need for further research to investigate factors driving the variability of effects.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Aida de Melo Spilack, Alessandra C. Goulart, Bianca de Almeida-Pititto, Carolina Castro Porto Silva Janovsky, Paulo A. Lotufo, Itamar de Souza Santos, Isabela M. Bensenor
Summary: The association of subclinical hypothyroidism and diabetes with carotid Intima-Media Thickness (cIMT) as a surrogate marker for early cardiovascular disease was analyzed. Diabetes was found to be associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected.
Article
Clinical Neurology
Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Lara Onofre Ferriani, Daniela Alves Silva, Maria del Carmen Bisi Molina, Jose Geraldo Mill, Andre Russowsky Brunoni, Maria de Jesus Mendes da Fonseca, Arlinda B. Moreno, Isabela M. Bensenor, Odaleia Barbosa de Aguiar, Sandhi Maria Barreto, Maria Carmen Viana
Summary: This study aimed to assess the association between depression and Metabolic Syndrome (MetS). The results showed that baseline depression was positively associated with recovered, incident, and persistent MetS. Baseline depression was also associated with specific components of MetS at follow-up, such as large waist circumference, high triglycerides, low high-density lipoprotein cholesterol, and hyperglycemia. The presence of three or more MetS components at follow-up was strongly associated with baseline depression. These findings suggest that depression is a risk factor for the development of MetS and emphasize the importance of monitoring metabolic and cardiovascular alterations in individuals with depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Ping-Tao Tseng, Yen-Wen Chen, Bing-Yan Zeng, Bing-Syuan Zeng, Chao-Ming Hung, Cheuk-Kwan Sun, Yu-Shian Cheng, Brendon Stubbs, Andre F. F. Carvalho, Andre R. R. Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Che-Sheng Chu, Mein-Woei Suen, Cheng-Ta Li
Summary: This network meta-analysis evaluated the efficacy and safety of noninvasive brain stimulation (NIBS) interventions in patients with Alzheimer's disease (AD). The combination of cathodal tDCS of the left dorsolateral prefrontal cortex and anodal tDCS over the right supraorbital region (c-tDCS-F3 + a-tDCS-Fp2) showed the most beneficial effect on cognition among all the investigated NIBS approaches. These findings provide evidence for the benefits of NIBS, particularly tDCS, in improving cognition in AD patients.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Natalia Gomes Goncalves, Marlon Juliano Romero Aliberti, Laiss Bertola, Thiago Avelino-Silva, Murilo Bacchini Dias, Daniel Apolinario, Geraldo Busatto, Orestes Forlenza, Ricardo Nitrini, Sonia Maria Dozzi Brucki, Andre Russowsky Brunoni, Kallene Summer Moreira Vidal, Wilson Jacob-Filho, Claudia Kimie Suemoto
Summary: Cognitive impairment is common after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study explores the associations between post-hospital discharge risk factors and cognitive trajectories in COVID-19 patients. The study found three groups of cognitive trajectories, with older age, female sex, previous dementia diagnosis or memory complaints, frailty before hospitalization, higher platelet count, and delirium as predictors of cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Jean-Marie Batail, Raphael Gaillard, Emmanuel Haffen, Emmanuel Poulet, Anne Sauvaget, David Szekely, Jerome Brunelin, Samuel Bulteau, Maxime Bubrovszky, Julien Smadja, Alexis Bourla, Noomane Bouaziz, Dominique Januel, Maud Rotharmel, Martijn Arns, Jonathan Downar, Paul B. Fitzgerald, Andre R. Brunoni, Stefano Pallanti, Giordano D'Usro, Chris Baeken, Nolan R. Williams, Bruno Millet, Jean-Pascal Lefaucheur, Dominique Drapier
Article
Neurosciences
Cesar Cimonari de Almeida, Iuri Santana Neville, Cintya Yukie Hayashi, Alexandra Gomes dos Santos, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Summary: The study evaluated the feasibility of using neuronavigated transcranial magnetic stimulation (nTMS) for plasticity evaluation in adult patients with gliomas. nTMS was performed to obtain quantitative and qualitative parameters related to plasticity in the motor area. The results showed that nTMS can demonstrate the occurrence of brain plasticity induced by intrinsic brain tumors quantitatively and qualitatively.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Psychiatry
Wei Zheng, Dong-Bin Cai, Sha Nie, Jian-Hua Chen, Xing-Bing Huang, Stephan Goerigk, Andre Russowsky Brunoni, Wei Zheng
Summary: This meta-analysis examined the therapeutic effects and tolerability of transcranial alternating current stimulation (tACS) for major depressive disorder (MDD) patients. The results showed that tACS had a modestly effective and safe impact on improving depressive symptoms in MDD patients.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Katia Nunes Sa, Rachel Fontes Baptista, Livia Shirahige, Lais B. Razzaa, Mateus Nogueira, Maria Helena Faria Coura, Leonardo Afonso-Santos, Clarice Tanaka, Abrahao Fontes Baptistaa, Katia Monte-Silva, Andre R. Brunonia
Summary: This study conducted an umbrella review to assess the available evidence of noninvasive brain stimulation (NIBS) in the treatment of anxiety disorders. The results showed that low-frequency repetitive transcranial magnetic stimulation (rTMS) is most effective for generalized anxiety disorder (GAD) and obsessive-compulsive disorder (OCD), while high-frequency rTMS has the largest effect size for posttraumatic stress disorder (PTSD). There is no evidence supporting the clinical use of NIBS for panic disorder (PD). Overall, NIBS is considered an effective and safe approach for treating GAD, PTSD, and OCD.
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Thiago Henrique Roza, Gabriel de Souza Seibel, Mariana Recamonde-Mendoza, Paulo A. Lotufo, Isabela M. Bensenor, Ives Cavalcante Passos, Andre Russowsky Brunoni
Summary: The study aimed to use machine learning classifiers to identify increased suicide risk in Brazilians with common mental disorders. Several models were developed using clinical and sociodemographic baseline data from a large Brazilian community sample. The Random Forests model performed the best, followed by Naive Bayes and Elastic Net. Depression symptoms were found to be the most relevant features for identifying increased suicide risk.
PSYCHIATRY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Vandrize Meneghini, William R. Tebar, Itamar Souza Santos, Carolina Castro Porto Silva Janovsky, Bianca de Almeida-Pititto, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor
Summary: This study investigated the relationship between psoriasis, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triodothyronine (FT3), thyroid peroxidase antibodies (TPOAb), and subclinical thyroid dysfunctions. The results showed a positive association between FT4 levels and psoriasis in women, and a significant association between FT3 levels and psoriasis in the overall sample and men. However, further prospective data are needed to clarify the association between thyroid function and psoriasis.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)