Journal
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Volume 13, Issue 6, Pages 785-791Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1461145709991209
Keywords
ECT; major depressive disorder; PET; 5-HT1A receptor
Funding
- Japanese Ministry of Health, Labor and Welfare [H19-kokoro-004]
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In our previous positron emission tomography (PET) study, we demonstrated that ECT decreased dopamine D, receptor in major depressive disorder (MDD). Although many animal studies have focused on the effect of ECT on serotonergic neurotransmission, no human study has directly examined the effect of ECT on brain serotonin [5-hydroxytryptamine (5-HT)] 1A receptors (5-HT(1A)Rs). Using PET with [C-11]WAY 100635, we aimed to evaluate the effect of ECT on 5-HT(1A)Rs in patients with MDD. Nine patients underwent PET scans before and after a series of 6-7 bilateral ECTs. Region-of-interest analysis was performed based on the simplified reference tissue model. There were no significant changes in 5-HT1AR binding in patients between before and after ECT. ECT did not alter [C-11]WAY 100635 binding even after recovery from depressive episode. Although the present finding does not exclude the involvement of brain 5-HT1A systems in the antidepressant action of ECT, it may indicate the involvement of other neurotransmission mechanisms.
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