Article
Computer Science, Artificial Intelligence
Adolfo Perrusquia
Summary: This paper reviews a novel method called Human-Behavior learning for designing optimal decision making controllers. Inspired by the complementary learning in different areas of the human brain, this method utilizes independent and well-identified sources of knowledge to enhance learning. The interaction is modeled as a Markov Decision Process and the paper connects existing methods from control and reinforcement learning theories for a class of linear systems.
Article
Computer Science, Information Systems
Adolfo Perrusquia, Weisi Guo
Summary: In this paper, a reward inference algorithm for discrete-time expert controllers is proposed, which utilizes the complementary mechanisms of the striatum, neocortex, and hippocampus to infer the reward function. The proposed approach combines data-driven and online learning methods and shows stability and convergence using Lyapunov stability theory.
INFORMATION SCIENCES
(2023)
Article
Neurosciences
Mamoru Tanaka, Takeshi Sakaba, Takafumi Miki
Summary: The study revealed that at the hippocampal mossy fibre-CA3 interneuron synapse, there is a high occupancy probability and release probability, which are crucial determinants of short-term synaptic depression.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Mathieu Di Miceli, Asma Derf, Benjamin Gronier
Summary: The study found that Methylphenidate (MPH) can modulate neurotransmitter efflux in brain regions enriched with dopamine and/or norepinephrine terminals, resulting in long-lasting alterations of striatal and prefrontal neurotransmission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Tima Zeng, Alexa Tompary, Anna C. Schapiro, Sharon L. Thompson-Schill
Summary: The study found that memories can be divided into specific memories and gist memories, and over time, gist memories start to guide item memories, with the interaction between the two changing as time passes.
Article
Neurosciences
Xuan Wang, Zhenfeng Shu, Quansheng He, Xiaowen Zhang, Luozheng Li, Xiaoxue Zhang, Liang Li, Yujie Xiao, Bo Peng, Feifan Guo, Da-Hui Wang, Yousheng Shu
Summary: This study found that parvalbumin neurons in the striatum have functional autapses, while principal spiny projection neurons do not. The autaptic responses in parvalbumin neurons are mediated by GABA(A) receptors and regulate their spiking activity. These autapses may play important roles in striatal functions.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Anna Churilova, Tatiana Zachepilo, Ksenia Baranova, Elena Rybnikova
Summary: Autophagy is an important degradation mechanism in cells, especially in neurons. This study found that the autophagy activity in hippocampal neurons is higher than that in neocortical neurons. The content of autophagy markers decreased in hippocampal neurons after exposure to hypoxia, while no significant changes were observed in neocortical neurons. These differences may reflect the physiological and functional disparities between these brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yue Zheng, Chen Zhao, Qiulin Song, Lichao Xu, Bo Zhang, Guangda Hu, Xiangfei Kong, Shaowen Li, Xiang Li, Yin Shen, Lenan Zhuang, Min Wu, Ying Liu, Yan Zhou
Summary: Appropriate histone modifications play a crucial role in regulating neuronal fate in neocortical areas and layers. NSD1 methyltransferase controls the area and layer identities of the neocortex. Nsd1 ablation leads to changes in the location of functional areas and aberrant cortico-thalamic-cortical projections.
Article
Behavioral Sciences
Ross van de Wetering, Jan A. Vorster, Sophie Geyrhofer, Joanne E. Harvey, Robert A. Keyzers, Susan Schenk
Summary: This study suggests that the sensitizing effects of MDMA are not due to changes in MDMA-produced synaptic overflow of serotonin in the medial striatum or the absorption/elimination of systemically administered MDMA, but more likely due to alterations in serotonin receptor mechanisms and/or dopamine neurotransmission following repeated exposure.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Neurosciences
Ricardo Martins-Ferreira, Barbara Leal, Joao Chaves, Tianlu Li, Laura Ciudad, Rui Rangel, Agostinho Santos, Antonio Martins da Silva, Paulo Pinho Costa, Esteban Ballestar
Summary: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common focal epilepsy in adults, characterized by high rates of drug resistance. Epileptogenesis in MTLE-HS is associated with epigenetic alterations, with previous studies mainly focused on the hippocampus. This study examines DNA methylation profiles in both the hippocampus and anterior temporal neocortex of MTLE-HS patients, showing altered DNA methylation patterns in multiple pathways related to epileptogenesis. The neocortex, which has less histopathological damage, also shows significant DNA methylation changes, suggesting its involvement in epilepsy development. These findings suggest a progressive wave of epigenetic dysregulation associated with inflammation-related genes in MTLE-HS.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Biology
Carmen Klein Herenbrink, Jonatan Fullerton Stoier, William Dalseg Reith, Abeer Dagra, Miguel Alejandro Cuadrado Gregorek, Reto B. Cola, Tommaso Patriarchi, Yulong Li, Lin Tian, Ulrik Gether, Freja Herborg
Summary: This study develops dopamine sensor cell lines expressing fluorescent reporters, which can be used to detect endogenous dopamine release, determine dopamine tissue content, and measure dopamine uptake and efflux. This versatile tool has a wide range of applications.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Paul F. Hill, Sarah E. Seger, Hye Bin Yoo, Danielle R. King, Bradley C. Lega, Michael D. Rugg, David X. Wang
Summary: The study found that the neurophysiological correlates of the BOLD signal differ between different brain regions, with a negative correlation between BOLD signal and high gamma SMEs in the hippocampus, and a positive correlation in the neocortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Behzad Zareian, Angelina Lam, Edward Zagha
Summary: This study investigated the roles of whisker motor cortex and dorsolateral striatum in a selective whisker detection task. The results showed that both brain regions are involved in the sensory-to-motor transformation, with the dorsolateral striatum playing a more crucial role.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemical Research Methods
Na Ying, Hanqi Luo, Baixia Li, Kaiyan Gong, Fei Liang, Hongchang Gao, Tao Huang, Hong Zheng
Summary: Exercise, including high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), can improve behavioral and cognitive impairments in Alzheimer's disease (AD) mice. Metabolomics analysis reveals significant changes in energy metabolism, neurotransmitter metabolism, and membrane metabolism in multiple brain regions after both types of exercises. HIIT also alters astrocyte-neuron metabolism in the hippocampus and hypothalamus of AD mice. These findings suggest that exercise can modulate brain metabolism in a region- and exercise-specific manner, potentially providing a novel approach for the prevention and treatment of AD.
JOURNAL OF PROTEOME RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Azzurra Margiotta
Summary: The myelin sheath is an important insulating layer around nerves that allows fast and efficient nerve conduction. It is formed by different cells in the central and peripheral nervous system. The myelin sheath's structure and composition play a crucial role in maintaining proper nerve function. The proteins SNAREs and rabs have been found to be involved in regulating myelin formation and maintenance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
F. Liu, S. Laguesse, R. Legastelois, N. Morisot, S. Ben Hamida, D. Ron
MOLECULAR PSYCHIATRY
(2017)
Correction
Biochemistry & Molecular Biology
F. Liu, S. Laguesse, R. Legastelois, N. Morisot, S. Ben Hamida, D. Ron
MOLECULAR PSYCHIATRY
(2018)
Article
Biochemistry & Molecular Biology
Sami Ben Hamida, Sophie Laguesse, Nadege Morisot, Jong-Hyun Park, Khanhky Phuamluong, Anthony L. Berger, Ki Duk Park, Dorit Ron
Article
Neurosciences
Sami Ben Hamida, Sueli Mendonca-Netto, Tanzil Mahmud Arefin, Md. Taufiq Nasseef, Laura-Joy Boulos, Michael McNicholas, Aliza Toby Ehrlich, Eleanor Clarke, Luc Moquin, Alain Gratton, Emmanuel Darcq, Laura Adela Harsan, Rafael Maldonado, Brigitte Lina Kieffer
BIOLOGICAL PSYCHIATRY
(2018)
Article
Neurosciences
L. J. Boulos, S. Ben Hamida, J. Bailly, M. Maitra, A. T. Ehrlich, C. Gaveriaux-Ruff, E. Darcq, B. L. Kieffer
NEUROPSYCHOPHARMACOLOGY
(2020)
Review
Clinical Neurology
Jeremie Neasta, Emmanuel Darcq, Jerome Jeanblanc, Sebastien Carnicella, Sami Ben Hamida
Article
Biochemistry & Molecular Biology
Sami Ben Hamida, Lucas Lecourtier, Michael Loureiro, Brigitte Cosquer, Antoine Tracqui, Valerie Simmoneaux, Astrid Nehlig, Byron C. Jones, Anne Pereira de Vasconcelos, Jean-Christophe Cassel
Summary: Our studies demonstrate that the combination of MDMA and ethanol can significantly enhance locomotor hyperactivity in rats, with dopamine D1 and glutamate NMDA receptor-mediated mechanisms in the ventral striatum playing a key role in this potentiation effect.
Article
Biochemistry & Molecular Biology
Sami Ben Hamida, Michelle Carter, Emmanuel Darcq, Marion Sourty, Md Toufiqur Rahman, Ann M. Decker, Chunyang Jin, Brigitte L. Kieffer
Summary: The study demonstrates that RTI-13951-33 can reduce alcohol drinking behavior in mice while leaving water drinking behavior intact. The compound is effective in C57BL/6 mice but not Gpr88 knockout mice, indicating its specificity in vivo. Additionally, RTI-13951-33 decreases alcohol self-administration and reduces the expression of alcohol reward-seeking behavior, suggesting its potential therapeutic effect for alcohol use disorders.
Article
Biochemistry & Molecular Biology
Sami Ben Hamida, Sarojini M. Sengupta, Ellie Clarke, Michael McNicholas, Eleonora Moroncini, Emmanuel Darcq, Marina Ter-Stepanian, Marie-Eve Fortier, Natalie Grizenko, Ridha Joober, Brigitte L. Kieffer
Summary: Both animal and human studies suggest that GPR88 is involved in Attention-Deficit/Hyperactivity Disorder (ADHD). Studies using Gpr88 knockout mice revealed ADHD-like behaviors, including increased motor impulsivity, reduced attention, and hyperactivity. The ADHD drug Atomoxetine reduced impulsivity in these mutant mice. Human genetic studies found associations between GPR88 variants and ADHD diagnosis, treatment response, and cognition, particularly in the presence of prenatal stress. Overall, GPR88 signaling appears to be a key factor in the diagnosis and treatment of ADHD.
MOLECULAR PSYCHIATRY
(2022)
Article
Chemistry, Medicinal
Md Toufiqur Rahman, Ann M. Decker, Sami Ben Hamida, David A. Perrey, Hetti Handi Chaminda Lakmal, Rangan Maitra, Emmanuel Darcq, Brigitte L. Kieffer, Chunyang Jin
Summary: We reported a new GPR88 agonist, RTI-122, with high potency and good metabolic stability, which could improve alcohol drinking behavior. This suggests that RTI-122 may serve as a promising lead compound for GPR88 agonist drug discovery research.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
A. C. Meirsman, S. Ben Hamida, E. Clarke, A. de Kerchove d'Exaerde, E. Darcq, B. L. Kieffer
Article
Multidisciplinary Sciences
Laura-Joy Boulos, Md Taufiq Nasseef, Michael McNicholas, Anna Mechling, Laura Adela Harsan, Emmanuel Darcq, Sami Ben Hamida, Brigitte Lina Kieffer
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Sami Ben Hamida, Laura-Joy Boulos, Michael McNicholas, Pauline Charbogne, Brigitte Lina Kieffer
Article
Neurosciences
Tanzil Mahmud Arefin, Anna E. Mechling, Aura Carole Meirsman, Thomas Bienert, Neele Saskia Huebner, Hsu-Lei Lee, Sami Ben Hamida, Aliza Ehrlich, Dan Roquet, Juergen Hennig, Dominik von Elverfeldt, Brigitte Lina Kieffer, Laura-Adela Harsan
BRAIN CONNECTIVITY
(2017)
Article
Neurosciences
Pauline Charbogne, Olivier Gardon, Elena Martin-Garcia, Helen L. Keyworth, Aya Matsui, Anna E. Mechling, Thomas Bienert, Taufiq Nasseef, Anne Robe, Luc Moquin, Emmanuel Darcq, Sami Ben Hamida, Patricia Robledo, Audrey Matifas, Katia Befort, Claire Gaveriaux-Ruff, Laura-Adela Harsan, Dominik von Elverfeldt, Jurgen Hennig, Alain Gratton, Ian Kitchen, Alexis Bailey, Veronica A. Alvarez, Rafael Maldonado, Brigitte L. Kieffer
BIOLOGICAL PSYCHIATRY
(2017)