Article
Fisheries
Jessica Fernandes de Souza, Andressa de Abreu Mello, Taynan Motta Portal, Rodrigo Nunes-da-Fonseca, Cintia Monteiro de Barros
Summary: DA, an important neurotransmitter, can modulate NO production in immune cells through adrenergic receptors in ascidian animals. The presence of catecholaminergic receptors on ascidian immune cells suggests unique pharmacological characteristics that may have evolutionary significance.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Suzane Rosa da Silva, Predrag Kalaba, Anna Fabisikova, Martin Zehl, Vladimir Dragatevie, Luana Ribeiro dos Anjos, Philip John Neill, Marcus Wieder, Alexander Prado-Roller, Natalie Gajic, Vinicius Palaretti, Gil Valdo Jose da Silva, Christian Pifl, Gert Lubec, Eduardo R. Perez Gonzalez
Summary: The study aimed to predict novel chemical entities with potential binding to the D1 dopamine receptor based on similarity search using known dopamine receptor agonists as scaffolds. Three compounds with high similarity indexes were synthesized, characterized, and subjected to bioactivity profiling against D1 and D2 receptors, as well as dopamine reuptake inhibition.
Article
Cell Biology
Fiona Limanaqi, Silvia Zecchini, Borana Dino, Sergio Strizzi, Gioia Cappelletti, Olga Utyro, Claudia Vanetti, Micaela Garziano, Irma Saulle, Mario Clerici, Mara Biasin
Summary: Recent evidence shows that the SARS-CoV-2 virus inhibits immune responses through dopamine-related mechanisms. In this study, the role of dopamine in SARS-CoV-2 replication was investigated in human lung cells, revealing that dopamine can reduce viral replication and affect the expression of D1 and D2 dopamine receptors. Additionally, dopamine can upregulate the expression of ISGs and Type-I interferons, while downregulating pro-inflammatory mediators. These findings highlight the correlation between dopamine pathways and the Type-I interferon response, which may be disrupted by SARS-CoV-2 for invasion and replication in host cells.
Article
Clinical Neurology
D'bora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rubensam, Robert Gerlai, Carla Denise Bonan
Summary: This study investigated the effects of the dopamine D2/D3 receptor agonist quinpirole on the behavior, brain-derived neurotrophic factor (BDNF), and neurotransmitter levels in adult zebrafish. The results showed that quinpirole administration caused decreased locomotor activity, increased anxiety-like behaviors, memory impairment, and stereotypic swimming in zebrafish. Furthermore, quinpirole treatment also decreased the number of BDNF-immunoreactive cells and altered glutamate and serotonin levels in the zebrafish brain. These findings suggest that quinpirole administration in adult zebrafish can be a useful tool for studying the mechanisms underlying neurological disorders related to the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Gemma L. Dalton, Stan B. Floresco, Anthony G. Phillips
Summary: The study examined the effects of different drugs on cognitive deficits related to schizophrenia, highlighting the potential of d-govadine as a treatment option. Results showed varying effects on cognitive tasks, suggesting the need for further clinical evaluation.
PSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Chen Jian-min, Wang Zhi-yuan, Wu Shi-xuan, Song Rui, Wu Ning, Li Jin
Summary: In this study, the effects of D-amphetamine and lisdexamfetamine on cognitive performance in rats were compared. The results showed that lisdexamfetamine was more effective than D-amphetamine in improving spatial cognitive performance, which could be attributed to its steady and lasting dopamine release pattern.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Cell Biology
Joseph T. Long, Jan Lammerding
Summary: Recent studies show that progressive nuclear deformation associated with cellular confinement triggers intracellular events promoting cell contractility and migration, indicating the nucleus plays a central role as a mechanosensor.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza
Summary: Trace amine-associated receptor 5 (TAAR5) modulates cognitive processes, potentially affecting the number of errors and the rate of task improvement.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jose A. Pino, Gabriel Nunez-Vivanco, Gabriela Hidalgo, Miguel Reyes Parada, Habibeh Khoshbouei, Gonzalo E. Torres
Summary: This study reveals that G protein beta gamma subunits can bind to the dopamine transporter (DAT) and activate DAT-mediated dopamine efflux, similar to the mechanism of action of psychostimulants like amphetamine (AMPH). Through a combination of computational biology, mutagenesis, biochemical, and functional assays, the amino acid residues within the 582-596 sequence of the DAT carboxy terminus involved in the DAT-G beta gamma interaction and G beta gamma-induced dopamine efflux were identified. Residues like R588 and F587 within the carboxy terminus of DAT play critical roles in the physical interaction between DAT and G beta gamma, influencing dopamine efflux.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jarkko Johansson, Madelene Ericsson, Jan Axelsson, Sara af Bjerken, Ana Virel, Nina Karalija
Summary: Mapping the effects of drugs on the entire brain is crucial for understanding the neural mechanisms behind drug-related behaviors. Using PET, this study investigated the regional and temporal characteristics of amphetamine-induced dopamine release in the brain, revealing distinct responses in different brain regions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Guillaume Fyfe-Desmarais, Frederik Desmarais, Eric Rassart, Catherine Mounier
Summary: Apolipoprotein D (ApoD) is a lipocalin that binds hydrophobic ligands. The upregulation of ApoD in various diseases, including Alzheimer's disease, Parkinson's disease, cancer, and hypothyroidism, is associated with decreased oxidative stress and inflammation. Recent studies have shown that ApoD modulates lipid mediators derived from arachidonic acid, as well as eicosapentaenoic acid and docosahexaenoic acid, in an anti-inflammatory manner. High levels of ApoD are also linked to better metabolic health and inflammatory state.
Article
Behavioral Sciences
Mengnan Guo, Tianyu Xiang, Min Li, Yue Sun, Shuang Sun, Dadian Chen, Qingmei Jia, Yuchuan Li, Xiaomeng Yao, Xiaojun Wang, Xiao Zhang, Feng He, Min Wang
Summary: This study investigated the different functions of DA D1R and D2R receptors in the striatum by examining the effects of agonists SKF38393 and quinpirole in 6-OHDA-lesioned and control rats. The results indicated that both agonists produced a dose-dependent increase in locomotor activity, with greater behavioral responses observed in lesioned rats compared to control rats. Additionally, quinpirole showed a greater dose-dependent increase in locomotor capacity compared to SKF38393 in lesioned rats. These findings may have implications for the development of selective dopamine therapies for Parkinson's disease.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sayed Ibrar Alam, Min Gi Jo, Tae Ju Park, Rahat Ullah, Sareer Ahmad, Shafiq Ur Rehman, Myeong Ok Kim
Summary: This study demonstrated that quinpirole significantly reduced glial cell-induced neuroinflammation in a TBI model through regulation of the D2R/Akt/GSK3β signaling pathway. Quinpirole treatment also attenuated neuronal apoptosis, synaptic dysfunction, and promoted recovery of lesion volume in the TBI mouse model.
Article
Multidisciplinary Sciences
Maria Angeles Cintado, Gabriel Gonzalez, Lucia Carcel, Luis Gonzalo de la Casa
Summary: In three experiments, the potential anxiolytic effects of sodium valproate, a drug used to treat seizures, were analyzed in rats. Injecting valproate prior to introducing a new flavor solution reduced neophobia in the presence of a context associated with the drug. However, a control group that received the drug showed reduced consumption. The drug also had negative effects on locomotor activity, which affected drinking behavior. Additionally, directly injecting the drug before a fear conditioning procedure tested its anxiolytic properties.
Article
Immunology
Zhubiao Ye, Jianru Chen, Pengran Du, Qingrong Ni, Baizhang Li, Zhe Zhang, Qi Wang, Tingting Cui, Xiuli Yi, Chunying Li, Shuli Li
Summary: This study aimed to determine the differences in specific fatty acids between vitiligo patients and healthy individuals and to investigate their association with clinical features. The results showed that the serological level of alpha-linolenic acid (ALA) was increased in vitiligo patients, while the levels of arachidonic acid (ARA), arachidic acid (AA), and behenic acid were decreased. ALA levels were positively associated with the vitiligo area scoring index (VASI). Supplementation with ARA or nordihydroguaiaretic acid (NDGA) could suppress the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)