Journal
MITOCHONDRION
Volume 21, Issue -, Pages 19-26Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2014.12.001
Keywords
Polymerase gamma mice; Glycolysis; GTT; Lactate; Gluconeogenesis
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
- American Federation for Aging Research
- Ellision Medical Foundation
- CIHR [119555]
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Several studies have illustrated that the polymerase gamma mutator (PolG) mice have reduced mitochondrial content secondary to systemic mitochondrial dysfunction, and subsequently a lower capacity to perform aerobic respiration and endurance exercise. We sought to delineate the extent of glycolysis as a means of energy production in the PolG mice in the absence of optimal mitochondrial function. PolG mice display an enhanced reliance on glycolysis as compared to their wild-type counterparts. This is evident by the resting hypoglycemia, higher PFK content, and elevated plasma lactate levels in the PolG mice. In vitro experiments provide further proof that PolG derived dermal fibroblasts have a higher rate of, and capacity for, glycolysis. PolG mice also have enhanced capacity to perform hepatic gluconeogenesis that is likely enhancing the Cori cycle capacity. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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