Journal
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Volume 23, Issue 1, Pages -Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0129065712500323
Keywords
Epileptic seizures; epileptogenicity; computational modeling; reactive stimulation; adaptive control
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We aim to derive fully autonomous seizure suppression paradigms based on reactive control of neuronal dynamics. A previously derived computational model of seizure generation describing collective degrees of freedom and featuring bistable dynamics is used. A novel technique for real-time control of epileptogenicity is introduced. The reactive control reduces practically all seizures in the model. The study indicates which parameters provide the maximal seizure reduction with minimal intervention. An adaptive scheme is proposed that optimizes the stimulation parameters in nonstationary situations.
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