Article
Neurosciences
Minghua Li, Jessica L. Kinney, Yu-Qiu Jiang, Daniel K. Lee, Qiwen Wu, Daehoon Lee, Wen-Cheng Xiong, Qian Sun
Summary: A key mode of neuronal communication between distant brain regions is through excitatory synaptic transmission mediated by long-range glutamatergic projections. However, we found that the glutamatergic projection from the hypothalamic supramammillary nucleus (SuM) largely avoids pyramidal neurons in hippocampal CA3 region and instead targets interneurons to provide feedforward inhibition. This novel long-range glutamatergic pathway suppresses the activity of principal neurons and reveals a new means by which SuM regulates hippocampal activity.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Alexandru Calin, Andrei S. Ilie, Colin J. Akerman
Summary: In this study, it was found that depolarization block in PV interneurons plays a significant role during the loss of inhibitory restraint, and that depolarization block in feedforward inhibitory synaptic mechanisms is a point of weakness.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Heekyung Lee, Zitong Wang, Scott L. Zeger, Michela Gallagher, James J. Knierim
Summary: Research suggests that there is a difference in neural activity along the transverse axis of the CA3 region in aged rats, which may lead to an imbalance between pattern separation and pattern completion, affecting the flexibility of representations.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Physics, Fluids & Plasmas
Costantino Di Bello, Alexander K. Hartmann, Satya N. Majumdar, Francesco Mori, Alberto Rosso, Gregory Schehr
Summary: This article investigates the effects of resetting on the distribution of the integrated particle current in a system of noninteracting particles on a line. Two different models, namely independent Brownian motion with resetting and run-and-tumble motion with resetting, are considered. The study shows that resetting induces a stationary limiting distribution of the current at long times, but the approach to the stationary state is drastically different for annealed and quenched cases. A third-order phase transition is observed in the rate function of the quenched distribution. Numerical and analytical methods are used to compute the associated rate functions for both models.
Review
Neurosciences
Hugo Balleza-Tapia, Luis Enrique Arroyo-Garcia, Arturo G. Isla, Raul Loera-Valencia, Andre Fisahn
Summary: Gamma oscillations in the hippocampal area CA3 are crucial for memory function. Recent studies have found that pyramidal cells (PCs) in CA3 are organized into different functional subpopulations, which play important roles in cognition-related network dynamics.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Can Dong, Antoine D. Madar, Mark E. J. Sheffield
Summary: The study found that CA1 and CA3 play different roles in spatial memory processing. Place fields in CA1 emerge rapidly but tend to shift backwards from trial-to-trial and remap upon re-exposure to the environment a day later, while place fields in CA3 develop gradually and show more stable trial-to-trial and day-to-day dynamics, indicating distinct functional roles in representing space for each subfield.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Anirudh R. Acharya, Lars Emil Larsen, Jean Delbeke, Wytse J. Wadman, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt
Summary: This study investigated the inhibitory effect of activating stGtACR2 on epileptic afterdischarges in the dentate gyrus. It was found that activation of stGtACR2 only reduced the line length of local field potential during illumination, but did not decrease the duration of afterdischarges.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Olivia A. Shipton, Clara S. Tang, Ole Paulsen, Mariana Vargas-Caballero
Summary: The study shows that both A beta and tau protein play a role in the development of Alzheimer's disease. A beta affects synaptic deficits in wild-type mice, but not in mice without tau protein. Additionally, CA3-CA1 synapses in the hippocampus with presynaptic axons from the left CA3 are more vulnerable to A beta.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Adam Gorlewicz, Barbara Pijet, Kristina Orlova, Leszek Kaczmarek, Ewelina Knapska
Summary: This study investigates the role of GluN2B in the pathophysiology of temporal lobe epilepsy and suggests the potential therapeutic use of ifenprodil, a GluN2B selective NMDAR antagonist. The findings provide insights into the factors contributing to recurrent seizures and propose a new candidate treatment for temporal lobe epilepsy.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biology
Koichiro Kajikawa, Brad K. Hulse, Athanassios G. Siapas, Evgueniy Lubenov, Adrien Peyrache
Summary: The study found that in awake mice, hippocampal ripples are influenced by the brain state and ripple modulation, with different responses to depolarization caused by entorhinal input in different hippocampal subfields. There is evident inhibition in CA3 during the ripple buildup, while DG and CA1 neurons exhibit depolarization transients.
Article
Biology
Adam Mago, Noemi Kis, Balazs Luko, Judit K. Makara
Summary: The dendrites of CA3 pyramidal cells exhibit diverse forms of Ca2+ spikes during different inputs, showing morpho-functional heterogeneity. These variations in dendritic Ca2+ spikes may underlie the diverse input-output transformation and bursting properties of CA3PCs.
Article
Neurosciences
Yasmine Belaidouni, Diabe Diabira, Jinwei Zhang, Jean-Charles Graziano, Francesca Bader, Aurelie Montheil, Clement Menuet, Gary A. Wayman, Jean-Luc Gaiarsa
Summary: The study found that in late symptomatic stages, there was no difference in the relative amount of KCC2 and NKCC1 in the hippocampus of Mecp2-null mice, but there was over-phosphorylation. There were also no differences in the inhibitory strength and reversal potential of GABA(A)-receptor-mediated responses in Mecp2-null CA3 pyramidal neurons compared to wild-type at any stages studied. These data indicate the presence of a functional chloride extrusion mechanism in Mecp2-null CA3 pyramidal neurons at symptomatic stages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Omar Hosea Cabrera, Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Summary: Anesthetics cause widespread neuroapoptosis and lasting cognitive impairments in the developing brains. This study shows that neonatal ketamine exposure interferes with normal neural circuit development and leads to lasting increase in excitatory synaptic transmission in the hippocampus.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Lucas Goirand-Lopez, Marie Moulinier, Alexandre Vigier, Celine Boileau, Alan Carleton, Sarah F. Muldoon, Thomas Marissal, Valerie Crepel
Summary: Temporal lobe epilepsy (TLE) is a common form of epilepsy in adults, characterized by aberrant epileptogenic network formed by mossy fiber sprouting. Kainate receptors (KARs) play a prominent role in this network by facilitating the recruitment of neurons into coactive cell assemblies, contributing to the occurrence of epileptiform network events.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Lei Dong, Ling Zhao, Lei Tian, Wenjun Zhao, Chan Xiong, Yu Zheng
Summary: The present study investigated the effects of AsHC 360 exposure on epileptiform discharges (EDs) in the hippocampus of infantile male rats in vitro. The findings suggest that the effects of AsHC 360 on EDs signals are concentration-dependent, with low concentrations showing reversible effects and high concentrations inhibiting the occurrence of epileptic discharges.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Thomas P. Ladas, Chia-Chu Chiang, Luis E. Gonzalez-Reyes, Theodore Nowak, Dominique M. Durand
EXPERIMENTAL NEUROLOGY
(2015)
Article
Engineering, Biomedical
Yazan M. Dweiri, Thomas Eggers, Grant McCallum, Dominique M. Durand
JOURNAL OF NEURAL ENGINEERING
(2015)
Article
Neurosciences
Chen Qiu, Rajat S. Shivacharan, Mingming Zhang, Dominique M. Durand
JOURNAL OF NEUROSCIENCE
(2015)
Article
Clinical Neurology
Hyun-Joo Park, Dominique M. Durand
Article
Neurosciences
Mingming Zhang, Rajat S. Shivacharan, Chia-Chu Chiang, Luis E. Gonzalez-Reyes, Dominique M. Durand
JOURNAL OF NEUROSCIENCE
(2016)
Article
Engineering, Biomedical
Thomas E. Eggers, Yazan M. Dweiri, Grant A. McCallum, Dominique M. Durand
JOURNAL OF NEURAL ENGINEERING
(2017)
Article
Engineering, Electrical & Electronic
Yazan M. Dweiri, Thomas E. Eggers, Luis E. Gonzalez-Reyes, Joseph Drain, Grant A. McCallum, Dominique M. Durand
PROCEEDINGS OF THE IEEE
(2017)
Article
Multidisciplinary Sciences
Grant A. McCallum, Xiaohong Sui, Chen Qiu, Joseph Marmerstein, Yang Zheng, Thomas E. Eggers, Chuangang Hu, Liming Dai, Dominique M. Durand
SCIENTIFIC REPORTS
(2017)
Article
Clinical Neurology
Nicholas H. Couturier, Dominique M. Durand
Article
Clinical Neurology
Nicholas H. Couturier, Dominique M. Durand
Article
Clinical Neurology
Rajat S. Shivacharan, Chia-Chu Chiang, Xile Wei, Muthumeenakshi Subramanian, Nicholas H. Couturier, Nrupen Pakalapati, Dominique M. Durand
Summary: Research has shown that ephaptic coupling, a nonsynaptic mechanism, can recruit neurons during seizures, potentially explaining the low success rate of surgical transections in epilepsy patients. Experimental results indicate that electric fields can recruit neurons across tissue transections, affecting the overall neural network activity.
Article
Chemistry, Analytical
Joseph T. Marmerstein, Grant A. McCallum, Dominique M. Durand
Summary: In this study, a carbon nanotube yarn biosensor was used to chronically record and decode activity in the vagus nerve of freely moving rats. The study provides important insights into understanding spontaneous vagus nerve function.
Article
Computer Science, Information Systems
Yazan Dweiri, Mousa Al-Zanina, Dominique Durand
Summary: In this study, ensemble learning is used to enhance the performance of the convolutional neural network Axondeepseg (ADS) when applied to optical microscopy images. The results demonstrate that the ensemble model achieves a higher accuracy compared to the individual base models, and it provides automated segmentation and measurement of axon diameters and myelin thicknesses in neural images.
Review
Clinical Neurology
Sheela Toprani, Dominique M. Durand
Summary: This review discusses the use of neurostimulation therapies for epilepsy treatment, including vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation. Different therapeutic strategies and their underlying mechanisms are explored, with a focus on optimizing parameters for seizure reduction. The review also highlights the paradigm shift toward a more diverse and multimodal approach to deep brain neuromodulation.
Article
Neurosciences
Zhouyan Feng, Zhaoxiang Wang, Zheshan Guo, Wenjie Zhou, Ziyan Cai, Dominique M. Durand