Journal
MITOCHONDRION
Volume 24, Issue -, Pages 56-63Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2015.07.005
Keywords
Apoptosis; Mitochondria; Mitophagy; Neurodegeneration; Parthanatos; Poly(ADP-ribosylation)
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Funding
- frame of the Accordo Quadro Regione Lombardia - CNR, Italy [18089/RCC 2013]
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Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. (C) 2015 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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