Article
Oncology
Daichi Fujimoto, Hiroaki Akamatsu, Takeshi Morimoto, Kazushige Wakuda, Yuki Sato, Yoshitaka Kawa, Toshihide Yokoyama, Motohiro Tamiya, Ryota Hiraoka, Naoki Shingu, Hideki Ikeda, Akihiro Tamiya, Masaki Kanazu, Eisaku Miyauchi, Satoru Miura, Masaaki Yanai, Makiko Yomota, Ryotaro Morinaga, Takashi Yokoi, Akito Hata, Hidekazu Suzuki, Hirotaka Matsumoto, Shinya Sakata, Naoki Furuya, Yuhei Harutani, Ichiro Nakachi, Ayumu Otsuki, Shinya Uematsu, Satoshi Hara, Keiki Yokoo, Takeya Sugimoto, Nobuyuki Yamamoto
Summary: This study aimed to determine the incidence and clinical course of histologic transformation (HT) in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The study found that approximately 3% of EGFR-mutated patients developed HT after acquiring resistance to EGFR-tyrosine kinase inhibitors (TKIs). There was no significant difference in survival between patients with transformation to high-grade neuroendocrine carcinoma and those with transformation to another subtype of non-small cell lung cancer. Cytotoxic agents were likely to be effective in patients with HT, while the effectiveness of immune checkpoint inhibitors was limited.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Tianyu Zeng, Hai Xu, Yincheng Liu, Chunxiao Sun, Fan Yang, Yan Liang, Xiang Huang, Ziyi Fu, Wei Li, Yongmei Yin
Summary: This study assessed the frequency of lung cancer following breast cancer diagnosis and the associations between the two types of cancer. The results showed that breast cancer patients, especially those with low-grade malignancy, have a higher risk of developing primary lung cancer. Close follow-up is recommended for patients with isolated ground-glass nodules and high-risk factors. Additionally, EGFR may play an important role in primary lung adenocarcinomas and breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Fenge Li, Huancheng Wu, Xueming Du, Yimo Sun, Barbara Nassif Rausseo, Amjad Talukder, Arjun Katailiha, Lama Elzohary, Yupeng Wang, Zhiyu Wang, Gregory Lizee
Summary: The EGFR gene is frequently overexpressed and mutated in various solid tumors, and peptide vaccines targeting mutated EGFR have shown promising clinical efficacy and safety profiles.
Article
Immunology
Yulin Wang, Fenghui Liu, Songyun OuYang, Man Liu, Xue Zhang, Peng Wang, Chunling Zhao, Liguo Zhang, Liping Dai
Summary: This study found that anti-EGFR could be a potential biomarker for the diagnosis of lung cancer, and combining it with CEA could improve diagnostic value, regardless of EGFR gene mutations.
IMMUNOLOGIC RESEARCH
(2021)
Review
Oncology
Julia Lai-Kwon, Crescens Tiu, Abhijit Pal, Sachin Khurana, Anna Minchom
Summary: EGFR mutations are the most common targetable oncogenic driver mutation in metastatic non-small lung cancer. The development of third-generation inhibitor osimertinib has shown improved outcomes compared to first and second generation agents. Despite excellent initial response rates, responses may not be durable due to the development of acquired resistance, highlighting the importance of understanding resistance mechanisms and exploring drug combinations.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Zofia Piotrowska, Daniel Shao-Weng Tan, Egbert F. Smit, Alexander I. Spira, Ross A. Soo, Danny Nguyen, Victor Ho-Fun Lee, James Chih-Hsin Yang, Vamsidhar Velcheti, John M. Wrangle, Mark A. Socinski, Marianna Koczywas, John E. Janik, Jeffrey Jones, Helena Alexandra Yu
Summary: This study demonstrates that Zipalertinib has encouraging antitumor activity in heavily pretreated patients with EGFR ex20ins-mutant NSCLC, with an acceptable safety profile and low frequency of high-grade diarrhea and rash.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Alex Yang-Hao Yu, Ru-Huei Fu, Shan-hui Hsu, Chen-Feng Chiu, Wei-Hsiang Fang, Chun-An Yeh, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Utilizing collagen gold nanoparticles as a carrier for EGFR siRNA shows promising results in treating lung cancer, leading to significant tumor suppression effects and improved survival rates.
MATERIALS TODAY ADVANCES
(2021)
Review
Cell Biology
Heba M. Mansour, Hala M. Fawzy, Aiman S. El-Khatib, Mahmoud M. Khattab
Summary: This article discusses the role of epidermal growth factor receptor in Alzheimer's disease and the research progress on its downstream signaling pathways, presenting its therapeutic effects and the controversy surrounding it. It also explores the neurological manifestations induced by SARS-COVID-19 and provides future research perspectives.
NEURAL REGENERATION RESEARCH
(2022)
Article
Oncology
Mark G. Kris, Tetsuya Mitsudomi, Solange Peters
Summary: Surgical resection followed by adjuvant cisplatin-based chemotherapy is recommended for stage IB-IIIA NSCLC. Recurrence rates are high, and EGFR-TKIs have improved outcomes for metastatic and EGFR-mutated lung cancers. Early identification of EGFR mutations is crucial for personalized treatment.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Hiroshi Nokihara, Hirokazu Ogino, Atsushi Mitsuhashi, Kensuke Kondo, Ei Ogawa, Ryohiko Ozaki, Yohei Yabuki, Hiroto Yoneda, Kenji Otsuka, Yasuhiko Nishioka
Summary: These data suggest that the efficacy of osimertinib may differ between EGFR T790M-positive and -negative NSCLC patients with PE. The presence of PE was independently associated with shorter PFS and OS in EGFR T790M-positive NSCLC patients, but not in EGFR T790M-negative patients.
Article
Oncology
Wei-Jyun Hua, Hsin Yeh, Zhi-Hu Lin, Ai-Jung Tseng, Li-Chen Huang, Wei-Lun Qiu, Tsung-Hsi Tu, Ding-Han Wang, Wei-Hung Hsu, Wei-Lun Hwang, Tung-Yi Lin
Summary: GMI, an immunomodulatory protein from Ganoderma microsporum, inhibits the phosphorylation of EGFR and suppresses tumor growth by inhibiting EGFR dimerization and eliminating EGFR-mediated signaling.
Article
Immunology
How-Wen Ko, Shian-Sen Shie, Chih-Wei Wang, Chi-Tsun Chiu, Chih-Liang Wang, Tsung-Ying Yang, Shou-Chu Chou, Chien-Ying Liu, Chih-Hsi Scott Kuo, Yu-Ching Lin, Li-Fu Li, Cheng-Ta Yang, Chin-Chou Wang
Summary: This study identifies a comprehensive spectrum of uncommon EGFR mutations and demonstrates a positive relationship between smoking status and the frequency of uncommon EGFR mutations, particularly complex uncommon EGFR mutations. The results suggest that smoking contributes to the development of complex EGFR mutations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Camille Leonce, Clemence Guerriau, Lara Chalabreysse, Michael Duruisseaux, Sebastien Couraud, Marie Brevet, Pierre-Paul Bringuier, Delphine Aude Poncet
Summary: Targeting EGFR alterations, particularly the L858R (Exon 21) mutation and Exon 19 deletion (del19), has significantly improved the survival of lung cancer patients. The study compared two rapid strategies for EGFR testing and found that ddPCR has higher sensitivity in detecting unique del19, while Idylla is an alternative in other situations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Jingwen Wei, Jing Xiang, Yue Hao, Jinfei Si, Wenxian Wang, Fangyin Li, Zhengbo Song
Summary: This study retrospectively analyzed the anemia status of NSCLC patients with EGFR mutations and found that baseline anemia is associated with poor prognosis. Patients without baseline anemia and those with grade < 2 anemia had longer overall survival.
BMC PULMONARY MEDICINE
(2022)
Article
Surgery
Shuonan Xu, Jianfei Zhu, Daixing Zhong, Wenchen Wang, Yinsheng Wen, Lanjun Zhang, Tao Jiang
Summary: This study aimed to analyze the heterogeneity in EGFR gene mutation and its impact on clinical outcomes in primary tumor and corresponding brain metastasis in NSCLC. The results showed that patients with inconsistent EGFR mutations had better outcomes compared to those with consistent mutations. Therefore, the heterogeneity of EGFR mutation status may have significant implications for the treatment and prognosis of NSCLC.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Biochemical Research Methods
J. M. Haber, P. R. C. Gascoyne, K. Sokolov
Article
Chemistry, Multidisciplinary
Jason Haber, Konstantin Sokolov
Article
Optics
Chih-Hao Liu, Dmitry Nevozhay, Alexander Schill, Manmohan Singh, Susobhan Das, Achuth Nair, Zhaolong Han, Salavat Aglyamov, Kirill Larin, Konstantin Sokolov
Article
Computer Science, Interdisciplinary Applications
Mohamed A. Naser, Diego R. T. Sampaio, Nina M. Munoz, Cayla A. Wood, Trevor M. Mitcham, Wolfgang Stefan, Konstantin V. Sokolov, Theo Z. Pavan, Rony Avritscher, Richard R. Bouchard
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2019)
Article
Biochemical Research Methods
Kazunori Hoshino, Pratixa. P. Joshi, Gauri Bhave, Konstantin V. Sokolov, Xiaojing Zhang
BIOMEDICAL OPTICS EXPRESS
(2014)
Article
Optics
Chih-Hao Liu, Dmitry Nevozhay, Hongqiu Zhang, Susobhan Das, Alexander Schill, Manmohan Singh, Salavat Aglyamov, Konstantin Sokolov, Kirill Larin
Article
Biochemical Research Methods
Dmitry Nevozhay, Michael Weiger, Peter Friedl, Konstantin Sokolov
BIOMEDICAL OPTICS EXPRESS
(2019)
Article
Biochemical Research Methods
Sangheon Han, Richard Bouchard, Konstantin Sokolov
BIOMEDICAL OPTICS EXPRESS
(2019)
Correction
Optics
Chih-Hao Liu, Dmitry Nevozhay, Hongqiu Zhang, Susobhan Das, Alexander Schill, Manmohan Singh, Salavat Aglyamov, Konstantin V. Sokolov, Kirill V. Larin
Article
Biochemical Research Methods
Paul Boerner, Dmitry Nevozhay, Maryam Hatamimoslehabadi, Harshdeep Singh Chawla, Fernando Zvietcovich, Salavat Aglyamov, Kirill Larin, Konstantin Sokolov
BIOMEDICAL OPTICS EXPRESS
(2020)
Article
Chemistry, Multidisciplinary
Sangheon Han, Tomasz Zal, Konstantin Sokolov
Summary: Nanoparticles with ultra-small sizes have potential advantages in biomedical applications, especially when functionalized with specific antibodies. This study used luminescence properties of 5 nm gold nanoparticles to investigate their intracellular trafficking and fate in live cells, revealing detachment of the coating and formation of clusters with strong luminescence. The results offer insights into the interactions of functionalized nanoparticles with cells, providing a basis for further research in this area.
Article
Chemistry, Analytical
G. Kelp, N. Arju, A. Lee, E. Esquivel, R. Delgado, Y. Yu, S. Dutta-Gupta, K. Sokolov, G. Shvets
Article
Acoustics
Srivalleesha Mallidi, Seungsoo Kim, Andrei Karpiouk, Pratixa P. Joshi, Konstantin Sokolov, Stanislav Emelianov
Proceedings Paper
Optics
Maria K. Jimenez, Sylvia Lam, Catherine Poh, Konstantin Sokolov
TRANSLATIONAL BIOPHOTONICS
(2014)