Article
Biochemistry & Molecular Biology
Dina Saginova, Elyarbek Tashmetov, Yevgeniy Kamyshanskiy, Berik Tuleubayev, Denis Rimashevskiy
Summary: This research aimed to assess the effect of bone allograft combined with platelet-rich plasma (PRP), recombinant human bone morphogenetic protein-2 (rhBMP-2), and zoledronic acid (Zol) on bone formation. The study found that the combination of PRP with bone allograft promoted new bone formation and neovascularization. Additionally, the use of rhBMP-2 induced higher bone formation but also excessive osteoclast activity. The local co-administration of Zol inhibited allograft resorption and new bone formation.
Article
Biochemistry & Molecular Biology
Lena-Christin Ingwersen, Marcus Frank, Hendrik Naujokat, Klaas Loger, Rainer Bader, Anika Jonitz-Heincke
Summary: Long-term exposure to BMP-2 promotes osteogenic differentiation and adipogenesis, and regulates mediators involved in osteoclast activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Xinye Chen, Shuang Wang, Xiaohui Zhang, Yuanman Yu, Jing Wang, Changsheng Liu
Summary: Bone fractures in aging patients often have slow healing rates and high complication rates. Injecting a fibrin gel with sulfated chitosan nanoparticles can improve bone regeneration and reduce inflammation at the fracture site. This gel also regulates macrophage function and effectively treats fractures in postmenopausal mice.
APPLIED MATERIALS TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Patricia Garcia-Garcia, Ricardo Reyes, Daniel Garcia-Sanchez, Flor Maria Perez-Campo, Jose Carlos Rodriguez-Rey, Carmen Evora, Patricia Diaz-Rodriguez, Araceli Delgado
Summary: This study successfully enhanced the bone density in osteoporotic mice by using aptamer-functionalized nanoparticles carrying SFRP1 silencing GapmeR, without causing any toxic effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Yue Gao, Shuai Wang, Biying Shi, Yuxuan Wang, Yimeng Chen, Xuanyi Wang, Eui-Seok Lee, Heng-Bo Jiang
Summary: This review discusses the GTR/GBR materials used in bone/tissue regeneration engineering and the functional properties required for these membranes. While no single modern membrane meets all the necessary characteristics, the development of novel modified materials provides new possibilities in this field.
Article
Materials Science, Biomaterials
Qi Gan, Hao Pan, Wenjing Zhang, Yuan Yuan, Jiangchao Qian, Changsheng Liu
Summary: This study evaluated the osteogenic activity of dual drugs (Dex and BMP-2) loaded into a gelatin scaffold in vivo, and investigated the mechanism of osteogenesis induced by these drugs using C2C12 cells. Results showed that the gelatin scaffold with Dex and BMP-2 significantly accelerated osteogenesis in vivo, and Dex enhanced the osteogenic effect of BMP-2 through activation of the Runx2 pathway.
REGENERATIVE BIOMATERIALS
(2022)
Article
Chemistry, Physical
Mariko Yamamoto Kawai, Ryosuke Ozasa, Takuya Ishimoto, Takayoshi Nakano, Hiromitsu Yamamoto, Marina Kashiwagi, Shigeki Yamanaka, Kazumasa Nakao, Hiroki Maruyama, Kazuhisa Bessho, Kiyoshi Ohura
Summary: The study investigates the potential and efficiency of transferring the bmp-2 gene to periodontal tissues for hard-tissue regeneration, showing that it promotes bone growth without adverse effects on bone quality.
Article
Biochemistry & Molecular Biology
Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Peric, Slobodan Vukicevic
Summary: The study found that adding Zoledronate (ZOL) to autologous bone graft substitute (ABGS) enhances the quality and quantity of newly formed bone, and also prolongs its longevity to a certain extent.
Article
Medicine, Research & Experimental
Rakshya Rana, Jiana T. Baker, Melissa Sorsby, Supriya Jagga, Shreya Venkat, Shaza Almardini, Eva S. Liu
Summary: X-linked hypophosphatemia (XLH) is caused by high serum fibroblast growth factor 23 (FGF23) levels, leading to impaired production of 1,25-dihydroxyvitamin D3 (1,25D). Impaired 1,25D action due to high FGF23 levels is the underlying cause of XLH enthesopathy development. Optimizing 1,25D replacement therapy is necessary to prevent enthesopathy in pediatric patients with XLH.
Article
Biotechnology & Applied Microbiology
Lauren K. Dobson, Suzanne Zeitouni, Eoin P. McNeill, Robert N. Bearden, Carl A. Gregory, W. Brian Saunders
Summary: The study found that canine MSCs require additional agonists for robust osteogenesis in vitro, a finding supported by in vivo experiments using a murine calvarial defect model. However, canine MSCs did not perform as well in vivo compared to human MSCs, suggesting differences in bone regeneration mechanisms between the two species.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Yanjie Wang, Jinghe Sun, Yanqi Zhang, Wenzhuan Liu, Sheng Yang, Jingfeng Yang
Summary: The combined use of SP-2 and BMP-2 enhanced osteoblastic differentiation by increasing ALP expression and mineralization speed, leading to higher levels of BMP-2, Runx-2, COL-I, OCN, and OPN expression. SP-2 acted as a more effective enhancer by increasing the binding efficiency between BMP-2 and its cell surface receptor, proving to be most effective at a dose of 5 μg/mL.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Clinical Neurology
James P. Foley, Elianna J. Fred, Silvia Minardi, Jonathan T. Yamaguchi, Allison C. Greene, Andrew A. Furman, Joseph G. Lyons, Jonathan T. Paul, Tejas S. Nandurkar, Kenneth R. Blank, Robert M. Havey, Muturi Muriuki, Avinash G. Patwardhan, Wellington K. Hsu, Stuart R. Stock, Erin L. Hsu
Summary: This study demonstrates sex-dependent differences in bone regeneration induced by rhBMP-2. Further investigation is needed to uncover the extent of and mechanisms underlying these sex differences, particularly at different doses of rhBMP-2.
Article
Biotechnology & Applied Microbiology
I. A. Nedorubova, T. B. Bukharova, Yu. D. Zagoskin, A. V. Vasilyev, T. E. Grigoriev, V. O. Mokrousova, S. N. Chvalun, D. V. Goldshtein, A. A. Kulakov
Summary: The biological properties of a new gene-activated osteoplastic material based on chitosan sponges impregnated with plasmids with the gene BMP-2 for bone morphogenetic protein-2 have been studied. The in vitro osteoinductive effect of the developed material is associated with an increase in the expression of osteogenic markers in mesenchymal stromal cells. The designed gene-activated material can be used to repair bone defects.
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Liang Song, Xianrui Xie, Cuiting Lv, Atta Ur Rehman Khan, Yang Sun, Ruixue Li, Juan Yao, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Xiumei Mo, Youcheng Yu
Summary: This study reports on a biomaterial formulation that prevents soft tissue migration into bone defects through a barrier membrane, leading to successful bone regeneration. The nanofibrous membrane, encapsulating EGCG, demonstrates desirable properties and sustained release capability, resulting in repair of 70% of the defect area.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Daisuke Tateiwa, Shinichi Nakagawa, Hiroyuki Tsukazaki, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Yuichiro Ukon, Hiromasa Hirai, Takashi Kaito
Summary: NOVOSIS putty (NP), a composite material, shows great potential in promoting bone regeneration and osteoblast differentiation through the sustained release of recombinant human BMP-2. In a rat spinal fusion model, the NP group demonstrated higher volume and quality of newly formed bone compared to the collagen sponge (CS) group.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
JunJun Liu, Daowei Li, Kai Zhang, Mingxi Yang, Hongchen Sun, Bai Yang
Article
Dentistry, Oral Surgery & Medicine
Xue Zhang, Qilin Liu, Huan Zhao, Yue Hu, Cangwei Liu, Guangxing Yan, Daowei Li, Yuji Mishina, Ce Shi, Hongchen Sun
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Daowei Li, Kai Zhang, Ce Shi, Lijun Liu, Guangxing Yan, Cangwei Liu, Yijun Zhou, Yue Hu, Hongchen Sun, Bai Yang
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Cell Biology
Xue Zhang, Ce Shi, Huan Zhao, Yijun Zhou, Yue Hu, Guangxing Yan, Cangwei Liu, Daowei Li, Xinqing Hao, Yuji Mishina, Qilin Liu, Hongchen Sun
JOURNAL OF MOLECULAR HISTOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Junjun Liu, Yijia Geng, Daowei Li, Hua Yao, Zepeng Huo, Yunfeng Li, Kai Zhang, Shoujun Zhu, Haotong Wei, Weiqing Xu, Jinlan Jiang, Bai Yang
ADVANCED MATERIALS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Daowei Li, Liang Zhao, Mingyu Cong, Lijun Liu, Guangxing Yan, Zhimin Li, Baoquan Li, Weixian Yu, Hongchen Sun, Bai Yang
Article
Nanoscience & Nanotechnology
Boyu Yang, Miao Wu, Shujie Pang, Daowei Li, Yizhou Yang, Liying Wang, Zhenyu Li, Jiyuan Zhang, Xudong Yang
Article
Dentistry, Oral Surgery & Medicine
Xinchen Liu, Lin Meng, Xing Li, Daowei Li, Qilin Liu, Yumeng Chen, Xiangwei Li, Wenhuan Bu, Hongchen Sun
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2020)
Article
Engineering, Biomedical
Chunxia Ren, Xinqing Hao, Lu Wang, Yue Hu, Lin Meng, Shize Zheng, Feilong Ren, Wenhuan Bu, Huan Wang, Daowei Li, Kai Zhang, Hongchen Sun
Summary: Metformin carbon dots (MCDs) prepared in this study showed excellent biocompatibility and enhanced osteogenic activity more effectively under inflammatory conditions compared to metformin. MCDs also demonstrated promising potential for regenerating lost alveolar bone in periodontitis rat model, indicating a novel nanomaterial for periodontitis treatment with potential pharmacological targets.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Lu Wang, Shuwei Liu, Chunxia Ren, Siyuan Xiang, Daowei Li, Xinqing Hao, Shilei Ni, Yixin Chen, Kai Zhang, Hongchen Sun
Summary: Nanomaterial-based drug sustainable release systems have been tentatively used for bone regeneration, but still face challenges of high toxicity, low biocompatibility, and low drug capacity. The evaluation of hollow polydopamine nanoparticles showed efficient loading and sustained release of osteogenic drugs with low toxicity and high biocompatibility, promoting osteogenic differentiation and proliferation in vitro and bone regeneration in vivo. The biodegradable hollow polymer nanoparticles have potential for future clinical application in treating bone defects.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Engineering, Biomedical
Dongyang Wang, Xiaomeng Wang, Lei Huang, Ziyi Pan, Kexuan Liu, Beibei Du, Ying Xue, Bei Li, Yuan Zhang, Huan Wang, Daowei Li, Hongchen Sun
Summary: This study explores the impact of pathological mineralization (PTM) on inflammation using electrospun nanofibers. The results show a continuous decrease in inflammatory response during mineralization, with inflammation almost disappearing when mature macromineralization forms. Mechanistically, PTM formation is mediated by matrix proteins, local high calcium, and cell debris, or regulated by components secreted by macrophages, leading to reduced immune responses.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Huan Wang, Dongqin Yu, Jiao Fang, Ya Zhou, Daowei Li, Zhen Liu, Jinsong Ren, Xiaogang Qu
Article
Materials Science, Biomaterials
Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Bo Wang, Mingxi Yang, Lijun Liu, Guangxing Yan, Hongjing Yan, Jing Feng, Zhimin Li, Daowei Li, Hongchen Sun, Bai Yang
BIOMATERIALS SCIENCE
(2019)
Article
Oncology
Jinzhong Liu, Liang Zhao, Ling Ni, Chunyan Qiao, Daowei Li, Hongchen Sun, Zongtao Zhang
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2015)