Article
Pharmacology & Pharmacy
Mithun Saha, Diti Rani Saha, Tahamina Ulhosna, Shazid Md Sharker, Md Hasanuzzaman Shohag, Muhammad Saiful Islam, Swapan K. Ray, G. M. Sayedur Rahman, Hasan Mahmud Reza
Summary: The study successfully developed resveratrol-loaded mucoadhesive lecithin/chitosan nanoparticles to improve drug retention in the eye. Through risk assessments and optimized designs, the formulated nanoparticles had optimal characteristics such as 163.3 nm particle size, 97.03% entrapment efficiency, and zero-order release kinetics with an R2 value of 0.9897.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Salma A. Fereig, Ghada M. El-Zaafarany, Mona G. Arafa, Mona M. A. Abdel-Mottaleb
Summary: Lecithin-chitosan hybrid nanoparticles show promise as a nanocarrier for drug delivery, with the ability to encapsulate hydrophobic drugs effectively and release them in the upper skin layers. Through the use of suitable techniques and co-solvents, these nanoparticles can optimize drug encapsulation and achieve desirable therapeutic effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Applied
Jun Wang, Justin Liu, Dao-Qiang Lu, Lijing Chen, Rujia Yang, Dahai Liu, Bin Zhang
Summary: In this study, diselenide-crosslinked nanoparticles were successfully fabricated for doxorubicin delivery. The nanoparticles exhibited desirable morphology and size distribution, and the starting material used improved biocompatibility and physiological stability. The high drug encapsulation efficiency of the nanoparticles was achieved through electrostatic interactions between doxorubicin and the material. In vitro and in vivo experiments demonstrated that the doxorubicin-loaded diselenide-crosslinked nanoparticles had higher drug accumulation and enhanced growth inhibition compared to the control samples.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Olimpia Daniela Frent, Narcis Duteanu, Alin Cristian Teusdea, Stefania Ciocan, Laura Vicas, Tunde Jurca, Mariana Muresan, Annamaria Pallag, Paula Ianasi, Eleonora Marian
Summary: The aim of this study was to prepare microspheres based on biodegradable polymers and load them with a water-insoluble and environmentally sensitive active drug. The experimental results showed that the prepared microspheres had a high drug entrapment rate and could achieve controlled release of the active drug at the intestinal level. Furthermore, the microspheres exhibited good thermal stability, making them suitable for drug delivery systems.
Article
Neurosciences
Chandra Teja Uppuluri, Punna Rao Ravi, Avantika Dalvi
Summary: By developing lecithin-chitosan hybrid nanoparticles, the direct nose to brain uptake of Piribedil for Parkinson's disease treatment was improved, resulting in increased bioavailability in the brain. The development of this novel nanoformulation effectively addressed drug delivery issues present in traditional administration methods.
Article
Instruments & Instrumentation
Mohammed Elmowafy, Khaled Shalaby, Mohammed H. Elkomy, Omar Awad Alsaidan, Hesham A. M. Gomaa, Omnia M. Hendawy, Mohamed A. Abdelgawad, Hazim M. Ali, Yasmin M. Ahmed, Khalid M. El-Say
Summary: This study developed solid dispersion-loaded chitosan nanoparticles for colonic delivery of quercetin and aspirin. The coated formulation showed pH-dependent release and exhibited greater anti-inflammatory efficacy and histological improvements in the colon. Therefore, Eudragit L100-coated chitosan nanoparticles hold potential for delivering quercetin and aspirin to the colon.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Applied
Swarup Roy, Jong-Whan Rhim
Summary: Quercetin-loaded chitosan nanoparticles (QCNP) were prepared using a simple one-pot chemical reaction and incorporated into chitosan-based bioactive packaging films with excellent UV blocking properties. The addition of QCNP influenced the physical properties of the films and enhanced the release of quercetin under acidic and alcoholic conditions, showing potent antioxidant and antibacterial activity. The developed chitosan/QCNP-based films have promising applications in active food packaging.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Preeti Yadav, Awadh Bihari Yadav, Preksha Gaur, Vartika Mishra, Zul- Huma, Neelesh Sharma, Young-Ok Son
Summary: Mastitis is a devastating economic disease in dairy cattle, commonly occurring during the dry period or early lactation. Escherichia coli and Staphylococcus aureus are the main causative agents of mastitis in India. The use of ciprofloxacin-encapsulated nanocarriers shows potential in improving drug availability and providing an effective treatment for mastitis.
Article
Polymer Science
Yihao Zhang, Ruijia Liu, Qixu Feng, He Li, You Li, Xinqi Liu
Summary: The aim of this study was to prepare insulin-loaded nanoparticles using soybean trypsin inhibitor (STI) and chitosan (CS) as a potential coating. The nanoparticles were prepared by complex coacervation and characterized for their particle size, polydispersity index (PDI), and encapsulation efficiency. In vitro evaluation of simulated gastrointestinal digestion showed that the prepared nanoparticles could improve the stability of insulin in the gastrointestinal tract. These findings will provide a theoretical basis for improving the stability of oral insulin in the gastrointestinal tract.
Article
Biochemistry & Molecular Biology
Paulo R. Lino, Joao Leandro, Lara Figueiredo, Mariana P. Amaro, Lidia M. D. Goncalves, Paula Leandro, Antonio J. Almeida
Summary: This study introduces a systematic development of a delivery system based on chitosan (CS) and ionotropic gelation with tripolyphosphate (TPP) to nanoencapsulate human phenylalanine hydroxylase (hPAH) model, while maintaining protein stability and enzyme activity. By combining hyaluronic acid (HA) and cyclodextrins (CDs) as a set of biopolymers, hPAH was effectively entrapped within CS nanoparticles with improved stability and maintained activity, while achieving strict control of the formulation process. Detailed characterization showed that the lead formulations were internalized by hepatocytes, did not reveal cell toxicity, and presented a safe haemocompatible profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Priya Dhiman, Meenakshi Bhatia
Summary: In this study, ketoconazole, an antifungal drug, was encapsulated in quaternized chitosan nanoparticles. The quaternization of chitosan was confirmed by proton nuclear magnetic resonance spectroscopy. The KCZ-QCSNPs were characterized using various techniques, and their antimicrobial activities were evaluated.
Article
Pharmacology & Pharmacy
Katiuscia Vieira Jardim, Joseilma Luciana Neves Siqueira, Sonia Nair Bao, Alexandre Luis Parize
Summary: The objective of this study was to nanoencapsulate quercetin in chitosan nanoparticles and evaluate its release profile, cytotoxicity, and antioxidant activity. The chitosan nanoparticles showed good stability and high encapsulation efficiency, exhibiting significant cytotoxicity against tumor cells and superior antioxidant activity compared to free quercetin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Musaed Alkholief, Mohd Abul Kalam, Abdullah K. Alshememry, Raisuddin Ali, Sulaiman S. Alhudaithi, Nasser B. Alsaleh, Mohammad Raish, Aws Alshamsan
Summary: Linezolid-loaded chitosan nanoparticles were developed for the topical treatment of bacterial eye infections. The nanoparticles showed sustained drug release and enhanced antibacterial activity compared to the free drug.
Article
Multidisciplinary Sciences
Zahra Nabizadeh, Mahmoud Nasrollahzadeh, Ali Akbar Shabani, Majid Mirmohammadkhani, Davood Nasrabadi
Summary: Cartilage lesions, especially osteoarthritis, can cause pain and disability. This study aimed to develop chitosan-based nanoparticles for delivering fisetin, a compound with anti-inflammatory effects. The results showed that these nanoparticles were able to inhibit inflammatory responses and had good compatibility with cells and blood.
SCIENTIFIC REPORTS
(2023)
Article
Instruments & Instrumentation
Juhyun Park, Yeu-Chun Kim
Summary: Keloids are skin conditions induced by injuries, and a study has suggested a promising treatment method using microneedles to deliver 5-fluorouracil (5-FU) loaded carboxymethyl chitosan (CMC) nanoparticles directly into keloid fibroblasts. This delivery system not only inhibits the fibroblasts effectively but also has the feasibility of self-administration without pain, showing potential for treating keloid scars.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
