Article
Chemistry, Multidisciplinary
Kesong Yu, Yi Wu, Xiaoli Zhang, Junji Hou, Jingbo Chen
Summary: This study successfully prepared high-expansion poly(lactic acid)/poly(lactic acid) foam with excellent oil-water separation performance, and demonstrated its advantages in adsorption capacity, adsorption-desorption cycles, and heat resistance.
JOURNAL OF CO2 UTILIZATION
(2022)
Article
Materials Science, Multidisciplinary
Pei Feng, Jiye Jia, Li Yu, Anjie Min, Sheng Yang, Cijun Shuai
Summary: The addition of L-LA into PLLA scaffold promoted its degradation rate by weakening intermolecular forces and introducing hydrophilic functional groups, leading to reduced crystallinity and increased weight loss. The scaffold also exhibited good cytocompatibility for cell adhesion and growth with enhanced cell numbers and adhesion area over time.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Polymer Science
Lidong Feng, Xinchao Bian, Gao Li, Xuesi Chen
Summary: By investigating the thermal properties, morphology, and thermal stability of PLLA/PDLA blends, a new stereoamorphous mesophase (sam-PLA) structure was discovered, and the relationship between different phases in the PLLA/PDLA blends was explored.
Article
Polymer Science
Qianjin Zhu, Kaixin Chang, Liyan Qi, Xinyi Li, Woming Gao, Qinwei Gao
Summary: In this study, PLLA films were surface-modified using different solutions, leading to changes in their structure and properties. The modification with PDLA weakened the crystal structure of the films, while modification with PDLAG increased the stereocomplex (SC) structure and decreased the homogeneous crystal (HC) structure.
Article
Biochemistry & Molecular Biology
Wenjun He, Lin Ye, Phil Coates, Fin Caton-Rose, Xiaowen Zhao
Summary: The addition of poly(lactide-co-caprolactone) (PLCL) segments into poly(L-lactic acid) (PLLA)/poly(D-lactic acid) (PDLA) chains resulted in the development of a fully biodegradable and flexible PLLA/D-PLCL block polymer with long-chain branches and a stereocomplex (SC) crystalline structure. The PLLA/D-PLCL films showed increased complex viscosity/storage modulus, lower tan delta values in the terminal region, and strain-hardening behavior compared to neat PLLA. Through biaxial drawing, the uniformity and non-preferred orientation of the PLLA/D-PLCL films were improved. By introducing PDLA, the phase structure transformed from a sea-island structure to a co-continuous network structure, leading to enhanced tensile strength and elongation at break.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Yangzhe Hou, Han Jia, Yamin Pan, Chuntai Liu, Changyu Shen, Xianhu Liu
Summary: This study successfully prepared brand-new porous PLA films with enhanced flexibility and heat resistance using blade coating and thermally induced phase separation methods. The resulting blend films showed improved mechanical properties and high porosity, making them suitable for microfiltration, packaging, and modified applications.
Article
Biochemistry & Molecular Biology
Wei-Wei Chang, Jinye Niu, Hui Peng, Weifeng Rong
Summary: In this study, selective formation of stereocomplex (sc) crystallization and suppression of homocrystallization (hc) in high-molecular-weight (HMW) PLLA/PDLA blends were achieved by adding C70 as a nucleator. Fourier-transformed infrared spectroscopy analysis revealed improved intermolecular interactions and inhibited molecular chain diffusion and mobility, leading to accelerated sc crystallization. The addition of C70 also resulted in a higher thermal stability compared to the neat PLLA/PDLA blend.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Hanjou Park, Jeongmin Oh, Yaewon Park, Sungmin Kim, Jooyoun Kim
Summary: To address the problem of filter wastes, an ecofriendly alternative filter material using plant-sourced biomaterials, namely poly(lactic acid) (PLA) and fungal chitin, was developed. Heterogeneous electrospun fibers with distinctive chitin-rich and PLA-rich regions were formed by inducing phase separation between hydrophilic chitin and hydrophobic PLA polymers. The filtration performance of PLA and chitin-incorporated PLA (ChPLA) webs against NaCl nanoparticles was evaluated, and the study examined the contribution of mechanical and electrostatic particle capture mechanisms, as well as the effect of aging and environmental conditions. The research also demonstrated that ChPLA has higher degradability than PLA in a soil burial test.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Suyang Dai, Ziming Dai, Ni Jiang, Zhenbo Ning, Zhihua Gan
Summary: In this study, poly(L-lactide) (PLLA) was toughened by crosslinked polyurethane (CPU) through reactive blending. The resulting material exhibited significant increase in elongation at break, enhanced toughness, and shape memory capacity, showing great potential for applications in biodegradable green composites.
Article
Polymer Science
Alexis Theodorou, Vasilios Raptis, Chrissie Isabella Maria Baltzaki, Thrassyvoulos Manios, Vagelis Harmandaris, Kelly Velonia
Summary: In this study, we performed synthetic experiments and kinetic modeling calculations to investigate the polycondensation process of lactic acid and the formation of poly(lactic acid) (PLA). The results showed that under optimized conditions, PLLA with a weight-average molecular weight of 161 kDa could be obtained. The kinetic parameters obtained from the optimization accurately reproduced the experimental data.
Article
Polymer Science
Hideto Tsuji, Kazumasa Iguchi, Yuki Arakawa
Summary: The research studied the effects of different molecular weights of crystalline blocks but similar overall molecular weights on the crystallization behavior, structure, morphology, and thermal properties of PLLA-b-PDLLA/PDLA-b-PDLLA blends. It was found that the incorporated long amorphous PDLLA blocks facilitated unique SC crystallization in the blends with different crystalline block fractions.
Article
Engineering, Environmental
Weishuo Chen, Channa Zhong, Shuangcheng Li, Die Wen, Dongdong Zhou, Jun Shao, Shuiliang Chen, Haoqing Hou, Sheng Xiang
Summary: The blends of poly(D-lactic acid) and poly(L-lactic acid) (PDLA/PLLA) exhibit higher crystallization rate and mechanical strength than individual PDLA or PLLA due to the formation of stereocomplex crystals (SC). SC serves as an effective nucleating agent for PLA homochiral crystals (HC). However, the morphology of SC in asymmetric blends and its effect on the crystallization behavior of HC remains unclear. In this study, PDLA/PLLA blends with different weight ratios were prepared using different methods to obtain SC with different morphologies. The results showed that SC morphology influenced the formation of HC, with fibrous and banded SC inhibiting HC formation, spherical SC enhancing HC formation, and network structure SC significantly accelerating the crystallization rate of HC.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Applied
Yaowalak Srisuwan, Yodthong Baimark
Summary: This paper reports a study on flexible polymer blends made from PLLA-PEG-PLLA and TPS. The addition of TPS suppressed crystallizability of PLLA and PLLA-PEG-PLLA matrices, while greatly increasing the thermal stability of PLLA-PEG-PLLA. The PEG middle-blocks enhanced phase compatibility between PLLA-PEG-PLLA and TPS, resulting in ductile and flexible blend films.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Chemical
Vinothini Arunagiri, Adhimoorthy Prasannan, Jittrakorn Udomsin, Juin-Yih Lai, Chih-Feng Wang, Po-Da Hong, Hsieh Chih Tsai
Summary: The modified PCL/PDLLA melamine sponge sorbent shows excellent hydrophobicity and super-oleophilic wettability, making it suitable for oil-spill cleaning. Various physicochemical interactions were confirmed through analysis methods, demonstrating its high oil absorption capacity and purity.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Thermodynamics
Rui Zhang, Fanfan Du, Katalee Jariyavidyanont, Evgeny Zhuravlev, Christoph Schick, Rene Androsch
Summary: By analyzing different grades of PDLLA using fast scanning calorimetry, it is found that the glass transition dynamics of PDLLA and PLLA are essentially the same, suggesting that stereoisomerism does not influence the glass transition dynamics.
THERMOCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Lan Mei, Bo Chen, Rangrang Fan, Min Wu, Chengxin Weng, Aiping Tong, Bingwen Zou, Hui Yang, Chunlai Nie, Gang Guo
Summary: This study constructs DNase-resistant and tumor-distinguishing DNA nano-assemblies based on crossover motifs, and found that 3HB equipped with three aptamers shows the best tumor discriminating ability.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Applied
Xiaoyan Liang, Min Mu, Rangrang Fan, Bingwen Zou, Gang Guo
Summary: Chitosan, with its biodegradable, biocompatible, nonimmunogenic and nontoxic properties, has shown great potential as a delivery material in cancer immunotherapy, improving drug effectiveness and offering broad application prospects.
CARBOHYDRATE POLYMERS
(2022)
Article
Oncology
Shasha Zhao, Yuelong Wang, Nian Yang, Min Mu, Zhiguo Wu, Hexian Li, Xin Tang, Kunhong Zhong, Zongliang Zhang, Cheng Huang, Ting Cao, Meijun Zheng, Guoqing Wang, Chunlai Nie, Hui Yang, Gang Guo, Liangxue Zhou, Xi Zheng, Aiping Tong
Summary: This study identified the crucial role of transcription factor SP20H in regulating B7-H3 expression and tumor progression, suggesting its potential as a target for improving anti-B7-H3 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Min Mu, Xiaoyan Liang, Na Zhao, Di Chuan, Bo Chen, Shasha Zhao, Guoqing Wang, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: A supramolecular nanoreactor (DOC@TA-Fe3+) based on tannic acid (TA), iron ion (Fe3+), and docetaxel (DOC) was developed for ferroptosis/apoptosis treatment in colorectal cancer, with microtubule inhibition, reactive oxygen species (ROS) generation, and glutathione peroxidase 4 (GPX4) inhibition.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Engineering, Biomedical
Rangrang Fan, Caili Chen, Junshan Hu, Min Mu, Di Chuan, Zhouyun Chen, Gang Guo, Jianguo Xu
Summary: A multifunctional gold nanorod-based nanosystem was developed in this study by attaching siRNA against B7-H3, glucose oxidase (GOx), and hyaluronic acid (HA), which enables efficient low-temperature photothermal therapy. The nanoplatform can induce tumor ablation without damage to healthy tissues by exhaust glucose to induce starvation therapy and reduce HSP. It also promotes treatment effectiveness by downregulating B7-H3 with siRNA.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Bo Chen, Linrui Cai, Rangrang Fan, Min Mu, Di Chuan, Yangmei Ren, Haifeng Chen, Gang Guo
Summary: This study introduces a novel nanoplatform (CBDM) for cancer therapy that can ameliorate tumor hypoxia and promote oxygen production, thus enhancing the therapeutic effect of photodynamic therapy.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Cheng Huang, Xing Duan, Jichao Wang, Qingqing Tian, Yangmei Ren, Kepan Chen, Zongliang Zhang, Yuanyou Li, Yunyu Feng, Kunhong Zhong, Yuelong Wang, Liangxue Zhou, Gang Guo, Xiangrong Song, Aiping Tong
Summary: The study developed a treatment strategy based on mRNA expression, utilizing LNPs to achieve high transfection efficiency and a potent antitumor effect.
Article
Pharmacology & Pharmacy
Bo Chena, Lan Mei, Rangrang Fan, Di Chuan, Yangmei Ren, Min Mua, Haifeng Chen, Bingwen Zou, Gang Guo
Summary: The combination of photothermal therapy with chemotherapy using a nanoplatform based on polydopamine-coated gold nanoparticles has shown promising potential in cancer treatment. The nanoplatform exhibited enhanced photothermal conversion efficiency and colloidal stability. By assembling an i-motif DNA nanostructure on the nanoplatform, pH-responsive characteristics were achieved. The addition of a targeting ligand, AS1411 aptamer, enhanced specific cellular uptake. The nanoplatform also showed excellent photothermal performance and efficient cancer cell inhibition under near-infrared irradiation. Overall, this nanoplatform has great potential in synergistic photothermal-chemotherapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Min Mu, Di Chuan, Hao Liu, Huan Hou, Jianhan Huang, Aiping Tong, Gang Guo, Jianguo Xu
Summary: Recombinant anti-B7-H3xCD3 bispecific antibodies (biAbs) were prepared and MMP-2-sensitive S-biAb/dEGCG@NPs were constructed for efficient and systemic glioblastoma (GBM) elimination. S-biAb/dEGCG@NPs showed enhanced intracranial accumulation compared to biAb/dEGCG@NPs, biAb/dEGCG complexes, and free biAbs. Furthermore, S-biAb/dEGCG@NPs induced GBM elimination by boosting the ferroptosis effect and enhancing immune checkpoint blockade (ICB) immunotherapy, making them promising antibody nanocarriers for enhanced cancer therapy.
Review
Biochemistry & Molecular Biology
Chenqian Feng, Bo Chen, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: With the advancement of cancer treatment and precision medicine, there is a growing demand for advanced and versatile drug delivery systems. Polyphenols, which can act as both active ingredients and building blocks, are being explored as potential multifunctional carriers for efficient and safe cancer therapy. This review discusses the recent advances in the design, synthesis, and application of polyphenol-based nanosystems and highlights the challenges and optimization needed for their clinical translation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Youping Li, Gaixia Liu, Mengting Wang, Yuling Zhang, Shiwan You, Jing Zhang, Gang Guo, Bo Han, Le Li, Na Zhao
Summary: In this study, a thermosensitive hydrogel (PPH hydrogel) was developed using poloxamer 407, poloxamer 188, and hydroxypropyl methylcellulose. The hydrogel loaded with tannic acid and mitomycin C showed excellent controlled drug release and anti-adhesive effects, making it a potential solution for preventing postoperative abdominal adhesion.
Review
Biotechnology & Applied Microbiology
Hui Li, Rangrang Fan, Bingwen Zou, Jiazhen Yan, Qiwu Shi, Gang Guo
Summary: With the rapid advancement of nanomedical technology, novel nanomaterials known as MXenes have gained significant attention in the field of biomedicine. MXenes, featuring ultrathin atomic thickness and high specific surface area, have shown great promise in various biomedical applications, including biosensors, diagnosis, therapy, antibacterial agents, implants, wearable devices, and immunotherapy. This review comprehensively summarizes the synthesis methods, surface modification strategies, and research progress of MXene-based materials, while also addressing the challenges associated with their clinical translation in biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo
Summary: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yangmei Ren, Lan Mei, Cheng Huang, Rangrang Fan, Bo Chen, Aiping Tong, Chao Wang, Haifeng Chen, Gang Guo
Summary: The researchers synthesized a photosensitive material based on nano-crystalline cellulose and further obtained stereocomplex crystallite (SC)-based micelle with folic acid for improved type I PDT. The SC-based micelle co-delivering DOX and MTH1 inhibitor could enhance ROS-induced oxidative stress injury and disrupt the ROS defense system of tumor tissues. The designed system combining PDT and chemotherapy displays an enhanced cell apoptosis process, inhibiting or eliminating tumors without toxic side effects.
ACS MATERIALS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yunyun Qi, Jinxiang Yang, Yaping Chi, Peng Wen, Zhongying Wang, Shiyi Yu, Rui Xue, Jingmin Fan, Hong Li, Wen Chen, Xinjun Wang, Yan Zhang, Gang Guo, Bo Han
Summary: Periodontitis is a common chronic inflammatory disease. Polyphenols from Turkish gall have significant antibacterial, anti-inflammatory, and antioxidant activities. This study developed a simple method to prepare nanoparticles encapsulated in a hydrogel for sustained release of effective constituents, demonstrating strong antibacterial activity against oral pathogens.
MOLECULAR BIOMEDICINE
(2022)
