Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia

(2018) Sherin Bakhashab et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Laminins and cancer stem cells: Partners in crime?

(2017) Yan Qin et al.   SEMINARS IN CANCER BIOLOGY

Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models

(2017) Silvia Valtorta et al.   Oncotarget

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Combination of metformin and 5-aminosalicylic acid cooperates to decrease proliferation and induce apoptosis in colorectal cancer cell lines

(2016) Mona M. Saber et al.   BMC CANCER

Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-β2

(2016) Corinna Seliger et al.   CELL CYCLE

Effect of diclofenac on SLC16A3/MCT4 by the Caco-2 cell line

(2016) Shotaro Sasaki et al.   Drug Metabolism and Pharmacokinetics

Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma

(2016) KOJI HARADA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Metformin potentiates the anticancer activities of gemcitabine and cisplatin against cholangiocarcinoma cells in vitro and in vivo

(2016) Hua-Qiang Zhu et al.   ONCOLOGY REPORTS

Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation

(2016) Verena Leidgens et al.   Oncotarget

Metformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk

(2016) Mei Peng et al.   Scientific Reports

Nestin as a marker of cancer stem cells

(2015) Jakub Neradil et al.   CANCER SCIENCE

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Metformin can block precancerous progression to invasive tumors of bladder through inhibiting STAT3-mediated signaling pathways

(2015) Qi Pan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Diabetes, use of antidiabetic drugs, and the risk of glioma

(2015) Corinna Seliger et al.   NEURO-ONCOLOGY

Metformin Suppresses Pancreatic Tumor Growth With Inhibition of NFκB/STAT3 Inflammatory Signaling

(2015) Xiang-Lin Tan et al.   PANCREAS

Molekulare Diagnostik in der Neuropathologie

(2015) W. Dietmaier et al.   PATHOLOGE

Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms

(2015) Verena Leidgens et al.   PLoS One

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

(2015) Balkrishna Chaube et al.   Oncotarget

Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

(2015) Julie Sesen et al.   PLoS One

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

(2015) Marta Gritti et al.   Oncotarget

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

(2014) Roger Stupp et al.   LANCET ONCOLOGY

P17.39 * TURN OLD INTO NEW: METFORMIN AS ANTINEOPLASTIC AGENT IN GLIOBLASTOMA

(2014) C. Seliger et al.   NEURO-ONCOLOGY

Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide

(2014) Krzysztof Łabuzek et al.   Pharmacological Reports

Isolation of Cancer Stem Cells from Three Human Glioblastoma Cell Lines: Characterization of Two Selected Clones

(2014) Fortunata Iacopino et al.   PLoS One

Non-Steroidal Anti-inflammatory Drugs Decrease E2F1 Expression and Inhibit Cell Growth in Ovarian Cancer Cells

(2013) Blanca L. Valle et al.   PLoS One

New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells

(2013) Eva Gottfried et al.   PLoS One

Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review

(2013) Monica Franciosi et al.   PLoS One

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model

(2012) Sridhar R. Chirasani et al.   INTERNATIONAL JOURNAL OF CANCER

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

(2012) Vera Miranda-Gonçalves et al.   NEURO-ONCOLOGY

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)

(2010) A. Nerstedt et al.   DIABETOLOGIA

Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis

(2009) C C Abnet et al.   BRITISH JOURNAL OF CANCER

Monocarboxylate transport in human corneal epithelium and cell lines

(2009) Kati-Sisko Vellonen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cancer stem cells and glioma

(2008) Sunit Das et al.   Nature clinical practice. Neurology