Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells

New trends on obesity and NAFLD in Asia

(2017) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease: A sign of systemic disease

(2017) Isabella Reccia et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1

(2016) Zhongshu Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells

(2016) Lu Zeng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

(S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation

(2016) Eun Jung Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats

(2016) Amit K. Keshari et al.   JOURNAL OF ETHNOPHARMACOLOGY

In-vivo absorption of pinocembrin-7-O-β-D-glucoside in rats and its in-vitro biotransformation

(2016) Wei-Wei Guo et al.   Scientific Reports

A concise review of non-alcoholic fatty liver disease

(2015) Nwe Ni Than et al.   ATHEROSCLEROSIS

Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease Therapy

(2015) Sandra Pisonero-Vaquero et al.   CURRENT MEDICINAL CHEMISTRY

Identification and quantitation of major phenolic compounds frompenthorum chinensepursh. by HPLC with tandem mass spectrometry and HPLC with diode array detection

(2015) Weiwei Guo et al.   JOURNAL OF SEPARATION SCIENCE

AMP-kinase pathway is involved in tumor necrosis factor alpha-induced lipid accumulation in human hepatoma cells

(2015) Qiong Lv et al.   LIFE SCIENCES

Time-dependent Changes and Association Between Liver Free Fatty Acids, Serum Lipid Profile and Histological Features in Mice Model of Nonalcoholic Fatty Liver Disease

(2014) Milena N. Stanković et al.   ARCHIVES OF MEDICAL RESEARCH

SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease

(2014) Motoyuki Kohjima et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells

(2014) JinJin Yin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1

(2014) Jing Dong et al.   JOURNAL OF LIPID RESEARCH

A new flavanone from the aerial parts ofPenthorum chinense

(2014) Meng Wang et al.   NATURAL PRODUCT RESEARCH

Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells

(2013) Chia-Hsin Huang et al.   ARCHIVES OF PHARMACAL RESEARCH

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway

(2013) Hai Yan Quan et al.   BIOCHEMICAL PHARMACOLOGY

Comment on Isolation and Identification of Compounds from Penthorum chinense Pursh with Antioxidant and Antihepatocarcinoma Properties: Pinocembrin and Its Rapidly Emerging Neuroprotective Effects

(2013) Shailendra Kapoor   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease

(2013) Yuki Kawano et al.   JOURNAL OF GASTROENTEROLOGY

From NAFLD in clinical practice to answers from guidelines

(2013) Fabio Nascimbeni et al.   JOURNAL OF HEPATOLOGY

Hepatocellular cancer: The impact of obesity, type 2 diabetes and a multidisciplinary team

(2013) Jessica Dyson et al.   JOURNAL OF HEPATOLOGY

Oxidative stress and protein carbonylation in adipose tissue — Implications for insulin resistance and diabetes mellitus

(2013) Tatjana Ruskovska et al.   Journal of Proteomics

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

(2013) So Hee Jin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antioxidant and anticomplement functions of flavonoids extracted from Penthorum chinense Pursh

(2013) Qiao-Hui Zeng et al.   Food & Function

Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

(2013) Azhar Rasul et al.   Biomed Research International

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase

(2012) W.-L. Chen et al.   DIABETOLOGIA

Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells

(2012) Hiu Yee Kwan et al.   EUROPEAN JOURNAL OF NUTRITION

The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology

(2012) Naga Chalasani et al.   GASTROENTEROLOGY

The Amber ff99 Force Field Predicts Relative Free Energy Changes for RNA Helix Formation

(2012) Aleksandar Spasic et al.   Journal of Chemical Theory and Computation

miR-340 inhibition of breast cancer cell migration and invasion through targeting of oncoprotein c-Met

(2011) Zheng-sheng Wu et al.   CANCER

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

(2011) Yu Li et al.   Cell Metabolism

Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity

(2010) Giovanni Musso et al.   ANNALS OF MEDICINE

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Antihyperglycemic and antihyperlipidemic activities of methanol:water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats

(2010) Ramesh Babu Kasetti et al.   FOOD AND CHEMICAL TOXICOLOGY

ERp57 is up-regulated in free fatty acids-induced steatotic L-02 cells and human nonalcoholic fatty livers

(2010) Hui Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway

(2010) Mary D. L. Chau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK as a mediator of hormonal signalling

(2009) Chung Thong Lim et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY