Article
Oncology
Zechen Wang, Viswanathan Muthusamy, Daniel P. Petrylak, Karen S. Anderson
Summary: Bladder cancer is a common malignancy worldwide, and FGFR3 alterations are frequently found in bladder cancer. The efficacy of FGFR inhibitors is limited, and most patients with FGFR3 fusions still experience relapse. This study discovered the synergistic combination of FGFR and HDAC inhibitors for bladder cancer and provided mechanistic insights. These preclinical studies support the potential translation of this combination therapy to early phase clinical trials.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Danijel Sikic, Helge Taubert, Johannes Breyer, Markus Eckstein, Veronika Weyerer, Bastian Keck, Jennifer Kubon, Wolfgang Otto, Thomas S. Worst, Maximilian C. Kriegnnair, Philipp Erben, Arndt Hartmann, Bernd Wullich, Ralph M. Wirtz, Sven Wach
Summary: Analysis of FGFR3 mRNA expression in stage T1 NMIBC patients showed that high FGFR3 expression is associated with significantly reduced recurrence-free survival but better overall survival. CDKN2A expression is associated with reduced overall survival, while patient age is associated with overall survival.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Hua-Ping Liu, Wei Jia, Gaohaer Kadeerhan, Bo Xue, Wenmin Guo, Lu Niu, Xiaoliang Wang, Xiaolin Wu, Haitao Li, Jun Tian, Dongwen Wang, Hung-Ming Lai
Summary: TP53 is the most frequently mutated gene in muscle invasive bladder cancer (MIBC), and two gene signatures have been developed for MIBC prognosis. However, they are limited to immune genes and cannot be used individually across platforms. This study developed a 13-gene pair model that can be used as a single-sample prognostic predictor in MIBC, applicable to any gene-expression platform without specific normalization requirements. The model showed statistically significant survival differences between high-risk and low-risk patients and could potentially be used for immunotherapy.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Hirotaka Horiguchi, Shingo Hatakeyama, Tohru Yoneyama, Mihoko Sutoh Yoneyama, Toshikazu Tanaka, Naoki Fujita, Teppei Okamoto, Hayato Yamamoto, Takahiro Yoneyama, Tadashi Yoshizawa, Yasuhiro Hashimoto, Toshiaki Kawaguchi, Chikara Ohyama
Summary: The study identified a significant association between Ki67 index and PD-L1 expression with tumor recurrence in MIBC patients, which can be used as prognostic markers. The pathomolecular risk score showed strong predictive ability for tumor recurrence and overall survival in MIBC patients.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Andrew J. Weickhardt, David K. Lau, Margeaux Hodgson-Garms, Austen Lavis, Laura J. Jenkins, Natalia Vukelic, Paul Ioannidis, Ian Y. Luk, John M. Mariadason
Summary: This study identified that FGFR3 fusion genes in bladder cancer cells confer sensitivity to FGFR inhibitors, but resistance is mainly mediated by alternate activation of MAPK signaling. Combination treatment with FGFR and pan-ERBB inhibitors can overcome this resistance.
Review
Oncology
Claudia Maria Ascione, Fabiana Napolitano, Daniela Esposito, Alberto Servetto, Stefania Belli, Antonio Santaniello, Sarah Scagliarini, Felice Crocetto, Roberto Bianco, Luigi Formisano
Summary: Bladder cancer is a heterogeneous malignancy and FGFR3 genomic alterations have emerged as potent oncogenic drivers. In this review, the role of FGFR3 in bladder cancer and the state-of-art of anti-FGFR3 treatment are summarized. Additionally, the clinical and molecular features of FGFR3-altered bladder cancers are investigated.
CANCER TREATMENT REVIEWS
(2023)
Article
Cell Biology
Lihua Yao, Xiaowu Zhong, Guangcheng Huang, Qiang Ma, Lei Xu, Hong Xiao, Xiaolan Guo
Summary: This study identified a correlation between high mRNA expression of TP53 family members (TP53, TP63, and TP73) and clinical cancer stages and nodal metastasis status in ESCA patients. TP53 expression was also significantly associated with the overall survival of ESCA patients. Additionally, downregulation of TP53 expression reduced ESCC cell migration and proliferation, potentially activating the mTOR signaling pathway and inhibiting TP53-dependent autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shuitang Deng, Jingfeng Ding, Hui Wang, Guoqun Mao, Jing Sun, Jinwen Hu, Xiandi Zhu, Yougen Cheng, Genghuan Ni, Weiqun Ao
Summary: This study explored the value of a deep learning model based on multiparametric magnetic resonance imaging in predicting Ki67 expression in prostate cancer. Multiple prediction models were constructed and the combined model showed superior predictive performance compared to the clinical model.
Article
Oncology
Isabel Grote, Stephan Bartels, Leonie Kandt, Laura Bollmann, Henriette Christgen, Malte Gronewold, Mieke Raap, Ulrich Lehmann, Oleg Gluz, Ulrike Nitz, Sherko Kuemmel, Christine Zu Eulenburg, Michael Braun, Bahriye Aktas, Eva-Maria Grischke, Claudia Schumacher, Kerstin Luedtke-Heckenkamp, Ronald Kates, Rachel Wuerstlein, Monika Graeser, Nadia Harbeck, Matthias Christgen, Hans Kreipe
Summary: In this study, genetic alterations associated with impaired endocrine proliferative response to short-term preoperative endocrine therapy in estrogen receptor-expressing breast cancer cases were analyzed. The study found that ERBB2 amplification and mutations of TP53 were significantly associated with impaired endocrine proliferative response. This suggests that impaired response to preoperative endocrine therapy could identify cases with primary endocrine resistance in early luminal breast cancer.
Article
Biology
Pei-Hang Xu, Siyuan Chen, Yanhao Wang, Shengming Jin, Jun Wang, Dingwei Ye, Xiaodong Zhu, Yijun Shen
Summary: This study investigates the impact of mFGFR3 on the immune status in bladder cancer and the regulation of immune response by FGFR3. The results reveal differential immunity caused by mFGFR3 and the FIPS model effectively predicts prognosis in bladder cancer by identifying patients with diverse immune infiltration and mFGFR3 status in different risk groups.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xuexiang Li, Yunxue Li, Bing Liu, Liang Chen, Fang Lyu, Pu Zhang, Qingliu He, Lulin Cheng, Chunyu Liu, Yarong Song, Yifei Xing
Summary: In this study, it was found that Erdafitinib induces incomplete autophagy and increases intracellular reactive oxygen species levels to kill cells. A resistant cell line, RT-112-RS, was established and P4HA2 was identified as a key player in Erdafitinib resistance. Further investigation revealed that P4HA2 stabilizes HIF-1a protein and activates downstream target genes to reduce reactive oxygen species levels in bladder cancer. These findings highlight the significant role of P4HA2 in mediating acquired resistance to Erdafitinib and suggest it as a potential target for bladder cancer treatment.
Review
Oncology
Eva Blondeaux, Luca Arecco, Kevin Punie, Rossella Graffeo, Angela Toss, Carmine De Angelis, Lucia Trevisan, Giulia Buzzatti, Sabine C. Linn, Peter Dubsky, Mara Cruellas, Ann H. Partridge, Judith Balman, Shani Paluch-Shimon, Matteo Lambertini
Summary: Approximately 10% of breast cancers are associated with the inheritance of a pathogenic variant (PV) in one of the breast cancer susceptibility genes, including TP53. Women harboring a TP53 PV carry a high lifetime risk of developing breast cancer. This review provides an overview of TP53 testing criteria, prevalence among breast cancer patients, and its prognostic and therapeutic implications. It also discusses the spectrum of TP53 alterations and treatment strategies.
CANCER TREATMENT REVIEWS
(2023)
Article
Cell Biology
Hongyan Li, Huayi Lu, Wanli Cui, Yufan Huang, Xuefei Jin
Summary: The study revealed an association between TP53 mutations and immunophenotype in MIBC patients, with the establishment of an immune prognostic model showing better survival prediction than conventional clinical characteristics. The research provided practical prognostic significance for MIBC patients and displayed the overarching landscape of the immune response in the MIBC microenvironment.
Article
Oncology
Zongtai Zheng, Zhuoran Gu, Feijia Xu, Niraj Maskey, Yanyan He, Yang Yan, Tianyuan Xu, Shenghua Liu, Xudong Yao
Summary: The study aimed to develop MRI-based radiomics signatures to predict Ki67 expression status in bladder cancer patients. The SMOTE-LASSO model successfully predicted Ki67 expression status, which was associated with patients' survival outcomes and may impact clinical decision-making.
Review
Oncology
Linda Tran, Jin-Fen Xiao, Neeraj Agarwal, Jason E. Duex, Dan Theodorescu
Summary: Recent developments in bladder cancer research have focused on identifying mutated genes, understanding cellular aspects, and advancing non-invasive diagnostic methods. Immune checkpoint inhibitor therapeutics have shown significant therapeutic impact, providing patients with better monitoring options and hope for prolonged survival.
NATURE REVIEWS CANCER
(2021)
Review
Urology & Nephrology
Leopold Durner, Christian Bach, Mohamed El Fatih El Howairis, Oliver W. Hakenberg, Noor Buchholz
UROLOGIA INTERNATIONALIS
(2016)
Article
Urology & Nephrology
Rajan Veeratterapillay, Rakesh Heer, Mark I. Johnson, Raj Persad, Christian Bach
CURRENT UROLOGY REPORTS
(2016)
Review
Surgery
R. Veeratterapillay, S. S. Goonewardene, J. Barclay, R. Persad, C. Bach
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2017)
Article
Urology & Nephrology
Sailaja Pisipati, Christian Bach, Datesh Daneshwar, Edward W. Rowe, Anthony J. Koupparis
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2014)
Review
Urology & Nephrology
Christian Bach, Sailaja Pisipati, Datesh Daneshwar, Mark Wright, Edward Rowe, David Gillett, Raj Persad, Anthony Koupparis
NATURE REVIEWS UROLOGY
(2014)
Review
Urology & Nephrology
George Papadopoulos, Andreas Bourdoumis, Stefanos Kachrilas, Christian Bach, Noor Buchholz, Junaid Masood
UROLOGIA INTERNATIONALIS
(2014)
Article
Urology & Nephrology
Martin Schoenthaler, Noor Buchholz, Erik Farin, Hammad Ather, Christian Bach, Thorsten Bach, John D. Denstedt, Hans-Martin Fritsche, Michael Grasso, Oliver W. Hakenberg, Ralf Herwig, Thomas Knoll, Franklin Emmanuel Kuehhas, Evangelos Liatsikos, Peter Liske, Michael Marberger, Palle J. S. Osther, Jose Manuel Reis Santos, Kemal Sarica, Christian Seitz, Michael Straub, Olivier Traxer, Alberto Trinchieri, Ben Turney, Arkadiusz Miernik
WORLD JOURNAL OF UROLOGY
(2014)
Article
Urology & Nephrology
Martin Schoenthaler, Arkadiusz Miernik, Klaus Offner, Wojciech Konrad Karcz, Dieter Hauschke, Sabina Sevcenco, Franklin Emmanuel Kuehhas, Christian Bach, Noor Buchholz, Konrad Wilhelm
INTERNATIONAL BRAZ J UROL
(2014)
Review
Andrology
Mikolaj Mendrek, Christian Bach, Nadine T. Gaisa, Thomas-Alexander Voegeli
Review
Urology & Nephrology
Philippe F. Mueller, Daniel Schlager, Simon Hein, Christian Bach, Arkadiusz Miernik, Dominik S. Schoeb
ARAB JOURNAL OF UROLOGY
(2018)
Review
Urology & Nephrology
Hartwig Schwaibold, Felix Wiesend, Christian Bach
ARAB JOURNAL OF UROLOGY
(2018)
Letter
Urology & Nephrology
Clive Sheridan, Christian Bach, Anthony Koupparis
ARAB JOURNAL OF UROLOGY
(2014)
Review
Urology & Nephrology
Arkadiusz Miernik, Sabina Sevcenco, Franklin Emmanuel Kuehhas, Christian Bach, Noor Buchholz, Fabian Adams, Konrad Wilhelm, Martin Schoenthaler
ARAB JOURNAL OF UROLOGY
(2014)
Review
Urology & Nephrology
Syed M. Nazim, Mohamed Fawzy, Christian Bach, M. Hammad Ather
ARAB JOURNAL OF UROLOGY
(2018)