Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/ijms19082385
Keywords
endometriosis; infertility; niche; inflammation; immunomodulation; mesenchymal stem cell
Funding
- National Science Council, Taiwan [NSC102-2628-B-038-008-MY3]
- Ministry of Science and Technology, Taiwan [MOST 103-2321-B-038-011, MOST 104-2321-B-038-003, MOST 105-2628-B-038-008-MY3, MOST 106-3114-B-038-001]
- Health and Welfare Surcharge of Tobacco Products [MOHW105-TDU-B-212-134001, MOHW106-TDU-B-212-144001, MOHW107-TDU-B-212-114014]
- Taipei Medical University [TMU-T104-06, TMU-T105-06, TMU-T106-03, 105TMU-CIT-01-3, 106TMU-CIT-01-3, DP2-107-21121-01-T-02]
- Taipei Medical University Hospital [103TMU-TMUH-05, 104TMU-TMUH-04, 105TMU-TMUH-10]
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Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects. This review will survey the latest evidence on the role of inflammatory niche in the peritoneal cavity, ovaries, and uterus of endometriosis patients. Nonhormone treatment strategies that target these inflammation processes are also included. Furthermore, mesenchymal stem cell-based therapies are highlighted for potential endometriosis treatment because of their immunomodulatory effects and tropism toward inflamed lesion foci. Potential applications of stem cell therapy in treatment of endometriosis-associated infertility in particular for safety and efficacy are discussed.
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