Activation of mGluR5 Attenuates NMDA-Induced Neurotoxicity through Disruption of the NMDAR-PSD-95 Complex and Preservation of Mitochondrial Function in Differentiated PC12 Cells

G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration

(2013) Vincent Degos et al.   ANNALS OF NEUROLOGY

Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease

(2013) Tao Chen et al.   CELLULAR SIGNALLING

Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons

(2013) Peng Luo et al.   FEBS Journal

Differential regulation of CaMKIIα interactions with mGluR5 and NMDA receptors by Ca2+in neurons

(2013) Dao-Zhong Jin et al.   JOURNAL OF NEUROCHEMISTRY

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl2-Induced Neurotoxicity in Differentiated PC12 Cells

(2013) Penglong Wang et al.   MOLECULES

Protective Effects of SKF-96365, a Non-Specific Inhibitor of SOCE, against MPP+-Induced Cytotoxicity in PC12 Cells: Potential Role of Homer1

(2013) Tao Chen et al.   PLoS One

Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death

(2013) A M Brennan-Minnella et al.   Cell Death & Disease

Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice

(2012) Faiza Ben-Mabrouk et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury

(2012) Kimberly R Byrnes et al.   Journal of Neuroinflammation

Protective Effects of mGluR5 Positive Modulators Against Traumatic Neuronal Injury Through PKC-Dependent Activation of MEK/ERK Pathway

(2012) Tao Chen et al.   NEUROCHEMICAL RESEARCH

The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

(2012) Marc-André Martel et al.   NEURON

Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model

(2012) Ming-Hong Hsieh et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons

(2011) Tao Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway

(2011) TAO CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroprotection against Traumatic Brain Injury by a Peptide Derived from the Collapsin Response Mediator Protein 2 (CRMP2)

(2011) Joel M. Brittain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch

(2011) Jose A. Matta et al.   NEURON

NMDA Receptors, mGluR5 and Endocannabinoids are Involved in a Cascade Leading to Hippocampal Long-Term Depression

(2011) Yukitoshi Izumi et al.   NEUROPSYCHOPHARMACOLOGY

Calcium-dependent mitochondrial function and dysfunction in neurons

(2010) Natalia B. Pivovarova et al.   FEBS Journal

Comparative evaluation of hypoxic–ischemic brain injury by flow cytometric analysis of mitochondrial membrane potential with JC-1 in neonatal rats

(2010) Dong Kyung Sung et al.   JOURNAL OF NEUROSCIENCE METHODS

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

(2009) Mariko Kato Hayashi et al.   CELL

Overexpression of the PDZ1 domain of PSD-95 diminishes ischemic brain injury via inhibition of the GluR6·PSD-95·MLK3 pathway

(2009) Shu-Qun Hu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

PSD-95 mediates membrane clustering of the human plasma membrane Ca2+ pump isoform 4b

(2008) Rita Padányi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distinct roles of group I mGlu receptors in striatal function

(2008) P. Bonsi et al.   NEUROPHARMACOLOGY

Role of metabotropic glutamate receptors in the control of neuroendocrine function

(2008) Daniela Durand et al.   NEUROPHARMACOLOGY