Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 8, Pages 14574-14590Publisher
MDPI
DOI: 10.3390/ijms150814574
Keywords
bone scaffolds; liquid phase; 45S5; mechanical properties; bioactivity
Funding
- The Natural Science Foundation of China [51222506, 81372366]
- Hunan Provincial Natural Science Foundation of China [14JJ1006]
- Program for New Century Excellent Talents in University [NCET-12-0544]
- Fok Ying-Tong Education Foundation, China [131050]
- Shenzhen Strategic Emerging Industrial Development Funds [JCYJ20130401160614372]
- Central South University [2013JSJJ011, 2013JSJJ046]
- The Open-End Fund for the Valuable and Precision Instruments of Central South University
- The Fundamental Research Funds for the Central Universities of Central South University
- State Key Laboratory of New Ceramic and Fine Processing Tsinghua University [KF201413]
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Fabrication of mechanically competent bioactive scaffolds is a great challenge in bone tissue engineering. In this paper, beta-tricalcium phosphate (beta-TCP) scaffolds were successfully fabricated by selective laser sintering combined with furnace sintering. Bioglass 45S5 was introduced in the process as liquid phase in order to improve the mechanical and biological properties. The results showed that sintering of beta-TCP with the bioglass revealed some features of liquid phase sintering. The optimum amount of 45S5 was 5 wt %. At this point, the scaffolds were densified without defects. The fracture toughness, compressive strength and stiffness were 1.67 MPam(1/2), 21.32 MPa and 264.32 MPa, respectively. Bone like apatite layer was formed and the stimulation for apatite formation was increased with increase in 45S5 content after soaking in simulated body fluid, which indicated that 45S5 could improve the bioactivity. Furthermore, MG-63 cells adhered and spread well, and proliferated with increase in the culture time.
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