Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 6, Pages 10150-10168Publisher
MDPI
DOI: 10.3390/ijms150610150
Keywords
bone morphogenetic protein; coating; orthopaedic implant; osteogenesis
Funding
- National Natural Science foundation of China [81371182]
- Natural Science Foundation of Zhejiang Province, China [LY13H140005]
- Health and Family Planning Commission of Zhejiang Province, China [2013KYA124]
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The loss of bone integrity can significantly compromise the aesthetics and mobility of patients and can be treated using orthopaedic implants. Over the past decades; various orthopaedic implants; such as allografts; xenografts and synthetic materials; have been developed and widely used in clinical practice. However; most of these materials lack intrinsic osteoinductivity and thus cannot induce bone formation. Consequently; osteoinductive functionalisation of orthopaedic implants is needed to promote local osteogenesis and implant osteointegration. For this purpose; bone morphogenetic protein (BMP)-functionalised coatings have proven to be a simple and effective strategy. In this review; we summarise the current knowledge and recent advances regarding BMP-functionalised coatings for orthopaedic implants.
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