Article
Plant Sciences
Ayshah Aysh ALrashidi, Emira Noumi, Mejdi Snoussi, Vincenzo De Feo
Summary: Pimenta dioica essential oil and its main compound, eugenol, showed antibacterial activity against Gram-negative and Gram-positive bacteria related to food intoxication. They also exhibited inhibition of quorum sensing-dependent mechanisms and biofilm formation.
Article
Engineering, Environmental
Huizhi Hu, Feng Luo, Yirong Liu, Xiangguo Zeng
Summary: Quorum sensing plays a crucial role in regulating bacterial ecological relations and physiological behaviors, particularly in the formation of biofilm and granular sludge. Understanding bacterial QS in engineered reactors is essential for improving wastewater treatment efficiency.
WATER SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Lubov Chernogor, Kseniya Bakhvalova, Alina Belikova, Sergei Belikov
Summary: Janthinobacterium sp. SLB01 strain, isolated from L. baicalensis sponge, is Gram-negative, motile, psychrotolerant, and exhibits proteolytic, lipolytic, and saccharolytic activity. It can also utilize citrates and reduce nitrates.
Review
Fisheries
P. Snega Priya, Seenivasan Boopathi, Raghul Murugan, B. Haridevamuthu, Aziz Arshad, Jesu Arockiaraj
Summary: Bacteria produce virulence factors that cause mortality in fish and crustaceans, and these factors require abundant quorum sensing (QS) signals and high cell density. QS signals not only interfere with cellular pathways and induce cell death in mammalian cells, but also impair the immune system, indicating their importance as a major virulence factor. In aquatic organisms, the impact of QS signals is still being explored. However, aquatic organisms produce enzymes that degrade and detoxify these signals, and physical and chemical factors also affect their stability. Understanding the influence of QS signals on aquatic organisms is crucial for controlling disease progression.
REVIEWS IN AQUACULTURE
(2023)
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Editorial Material
Biology
Shravan Pradeep, Paulo E. Arratia
Summary: A new model has been developed to predict the conditions under which a bacterial species will transition to a static lifestyle.
Article
Environmental Sciences
Wen-Qian Wang, Xiao-Chi Feng, Hong-Tao Shi, Yong-Mei Wang, Chen-Yi Jiang, Zi-Jie Xiao, Yu-Jie Xu, Xin Zhang, Yuan Yuan, Nan-Qi Ren
Summary: This study found that three phytochemicals can inhibit biofilm formation in Pseudomonas aeruginosa by obstructing the transmembrane transport of quorum sensing (QS) signals. The inhibitors affected the structure and composition of biofilms, suppressed bacterial motility and QS-related virulence factors, and decreased the extracellular concentration of QS signaling molecules. This study provides new insights and strategies for biofilm contamination control.
ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jyoti Sharma, Durai Sundar, Preeti Srivastava
Summary: Biosurfactants are surface-active molecules produced by microorganisms, forming a thin film on their surface to aid in interactions with other cell surfaces. They play a role in regulating bacterial motility and quorum sensing, and controlling cellular communication and virulence.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
I-Chieh Chien, Chiao-Yun Chu, Chien-Yu Huang
Summary: Membrane bioreactors (MBRs) are widely used in wastewater treatment due to their high-quality effluent production. However, biofilm formation on membrane surfaces remains a major limitation of this technique. Bacterial quorum quenching (QQ) has been proven successful in controlling biofouling in MBRs. This study isolated potential QQ bacteria and investigated their degradation rates against eight different AHLs. The results showed that four isolates exhibited consistent AHL removal capabilities, indicating their potential for mitigating biofilm formation on MBR membranes.
Article
Plant Sciences
Kaifa Chen, Yongsheng Zhu, Hongwei Su, Hao Jiang, Xin Liu
Summary: Through animal experiments, it was found that modified Zhibai Dihuang pill (MZD), a traditional Chinese medicine, has certain therapeutic effects on urinary tract infections caused by drug-resistant Escherichia coli, reducing white blood cell count, alleviating inflammation and renal fibrosis, inhibiting biofilm formation, and decreasing the expression of related genes.
PHARMACEUTICAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Aakansha Giri Goswami, Somprakas Basu, Tuhina Banerjee, Vijay Kumar Shukla
Summary: The biofilm, a community of microorganisms protected by a self-produced matrix, plays a vital role in infection and antimicrobial resistance. The formation, growth, and resistance mechanism of biofilm are still not fully understood. Although there have been studies on anti-biofilm and antimicrobial therapeutics, the lack of a clear clinical standard calls for the translation of laboratory research into novel bedside strategies. Biofilm is responsible for faulty wound healing and chronic wounds. Understanding its interaction with wounds and developing reproducible anti-biofilm measures in a clinical setting is the current challenge.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Food Science & Technology
Marta L. Cabo, Anai Rodriguez, Juan R. Herrera
Summary: Bacterial pathogens such as L. monocytogenes live in communities called biofilms, which contribute to their survival and persistence. In this study, cell communication signals in a L. monocytogenes-carrying microbial community were explored to develop new strategies to combat biofilms. Quorum quenching and quorum sensing activities were screened, and the effects of a Paracoccus lactone extract (PLE) on biofilm formation were studied. The results showed that the PLE significantly reduced the area occupied by biofilms formed by L. monocytogenes, demonstrating its potential as an antibiofilm agent.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Junlin Li, Zhifei Li, Jun Xie, Yun Xia, Wangbao Gong, Jingjing Tian, Kai Zhang, Ermeng Yu, Guangjun Wang
Summary: Quorum sensing (QS) is a key mechanism for regulating biofilm formation in bacteria. This study successfully engineered a PvdQ bacterium with highly efficient quorum quenching (QQ) activity, which effectively inhibited biofilm formation. The engineered bacteria exhibited strong AHL signal molecule quenching activity, significantly reduced the adhesion and biofilm formation of pathogenic bacteria, and downregulated the transcription of QS biofilm formation-related genes.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Food Science & Technology
Kirsi Savijoki, Paola San-Martin-Galindo, Katriina Pitkaenen, Minnamari Edelmann, Annika Sillanpaeae, Cim van der Velde, Ilkka Miettinen, Jayendra Z. Patel, Jari Yli-Kauhaluoma, Mataleena Parikka, Adyary Fallarero, Pekka Varmanen
Summary: By studying the effects of metabolic end-products of food-associated lactobacilli and propionibacteria on biofilm formation of Gram-negative pathogenic bacteria, it was found that these end-products can disrupt the quorum sensing system of the pathogenic bacteria, leading to the inhibition of biofilm formation.
Article
Biotechnology & Applied Microbiology
Ni Wang, Yujie Jin, Guoqing He, Lei Yuan
Summary: This study aimed to understand bacterial behaviors and social models in biofilms of thermophilic spoilage bacteria during milk powder processing. The results revealed that strong biofilm formers had high AI-2 activities and the interactional effects of extracellular metabolites and co-culture influenced biofilm formation. In mixed circumstances, intraspecific and interspecific extracellular metabolites played a significant role in collective bacterial behaviors.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Chemistry, Physical
Harshad Lade, Vikas Kumar, G. Arthanareeswaran, A. F. Ismail
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2017)
Article
Chemistry, Multidisciplinary
Harshad Lade, Won Jung Song, Young Jae Yu, Jun Hee Ryu, G. Arthanareeswaran, Ji Hyang Kweon
Review
Biochemistry & Molecular Biology
Diby Paul, Judy Gopal, Manish Kumar, Muthu Manikandan
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Review
Chemistry, Analytical
Manikandan Muthu, Anbarasu Deenadayalan, D. Ramachandran, Diby Paul, Judy Gopal, Sechul Chun
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2018)
Article
Environmental Sciences
Subramanium Thiyageshwari, Pandurangan Gayathri, Ramasamy Krishnamoorthy, Rangasamy Anandham, Diby Paul
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2018)
Article
Chemistry, Multidisciplinary
Se Chul Chun, Shang Xiaomin, Vimala Anthonydhason, Hyejin Jung, Shimels Tilahun Belachew, Judy Gopal, Diby Paul
APPLIED SCIENCES-BASEL
(2018)
Article
Environmental Sciences
Youngjae Yu, Keun-Young Park, Jaehyun Jung, Wonjung Song, Jaehyeok Kim, Junhee Ryu, Harshad Lade, Jihyang Kweon
JOURNAL OF ENVIRONMENTAL SCIENCES
(2019)
Article
Engineering, Chemical
Dasharath Kondhare, Sushma Deshmukh, Harshad Lade
Article
Chemistry, Multidisciplinary
Dasharath Kondhare, Anjaneyulu Kasa, Balaji Totawar, Venkat Bhadke, Harshad Lade
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2020)
Article
Medicine, General & Internal
Harshad Lade, Joon Hyun Park, Sung Hee Chung, In Hee Kim, Jung-Min Kim, Hwang-Soo Joo, Jae-Seok Kim
JOURNAL OF CLINICAL MEDICINE
(2019)
Review
Infectious Diseases
Harshad Lade, Jae-Seok Kim
Summary: MRSA is a prevalent bacterial pathogen worldwide, and finding new antibiotic targets is crucial for successful treatment. Most antibiotics target essential biochemical processes of S. aureus, such as cell wall synthesis. Further research into novel antibiotics targeting bacterial cellular processes could lead to new therapeutic strategies against antibiotic-resistant pathogens.
Article
Medicine, General & Internal
Harshad Lade, Jung-Min Kim, Yousun Chung, Minje Han, Eun-Kyung Mo, Jae-Seok Kim
Summary: This study evaluated the performance of two multiplex nucleic acid amplification assays for simultaneous detection of multiple respiratory pathogens. The results showed consistent performance between the Allplex Respiratory Panel and the BioFire FilmArray, with some variations in detection rates for specific pathogens.
Article
Biotechnology & Applied Microbiology
Harshad Lade, Sung Hee Chung, Yeonhee Lee, Bajarang Vasant Kumbhar, Hwang-Soo Joo, Yun-Gon Kim, Yung-Hun Yang, Jae-Seok Kim
Summary: This study demonstrates the potential therapeutic effect of thymol in inhibiting PSM production in Staphylococcus aureus.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Harshad Lade, Sung Hee Chung, Yeonhee Lee, Hwang-Soo Joo, Jae-Seok Kim
Summary: This study measured the production of PSMs in clinical isolates of S. aureus and found that MSSA isolates had higher levels of PSM alpha 1, PSM alpha 2, and PSM beta 1 compared to MRSA isolates. Additionally, SCCmec type II strains showed lower PSM production and most of them did not produce delta-toxin. The spa type and SCCmec type were important factors in determining PSM production.
Review
Infectious Diseases
Harshad Lade, Hwang-Soo Joo, Jae-Seok Kim
Summary: MRSA is a drug-resistant pathogen with the ability to resist multiple antibiotics. It utilizes various resistance mechanisms to evade antibiotic action. This review discusses the molecular basis of MRSA resistance to non-beta-lactam antibiotics, providing insights for the development of new treatment approaches and detection methods for antibiotic resistance.