Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 15, Issue 12, Pages 22786-22800Publisher
MDPI
DOI: 10.3390/ijms151222786
Keywords
drug delivery; ethosome; 5-fluorouracil; gel; hypertrophic scars penetration
Funding
- National Natural Science Foundation of China (NSFC) [81301672, 81272114, 81401771]
- Natural Science Foundation of Shanghai [12ZR1415800]
- Shanghai Jiao Tong University Medical-Engineering Cross Fund [YG2012MS31]
- Shanghai Health Bureau [20114212]
- China Postdoctoral Science Foundation [2014M560296]
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Applying Ethosomal Gels (EGs) in transdermal drug delivery systems has evoked considerable interest because of their good water-solubility and biocompatibility. However, there has not been an explicit description of applying EGs as a vehicle for hypertrophic scars treatment. Here, a novel transdermal EGs loaded with 5-fluorouracil (5-FU EGs) was successfully prepared and characterized. The stability assay in vitro revealed that 5-FU EGs stored for a period of 30 days at 4 +/- 1 degrees C had a better size stability than that at 25 +/- 1 degrees C. Furthermore, using confocal laser scanning microscopy, EGs labeled with Rhodamine 6 G penetrated into the deep dermis of the hypertrophic scar within 24 h in the rabbit ear hypertrophic model suggested that the EGs were an optional delivery carrier through scar tissues. In addition, the value of the Scar Elevation Index (SEI) of 5-FU EGs group in the rabbit ear scar model was lower than that of 5-FU Phosphate Buffered Saline gel and Control groups. To conclude, these results suggest that EGs delivery system loaded 5-fluorouracil is a perfect candidate drug for hypertrophic scars therapy in future.
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