Melatonin-Based Therapeutics for Neuroprotection in Stroke

The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression

(2012) Linyu Chen et al.   BRAIN RESEARCH

Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals

(2012) Jinse Park et al.   BRAIN RESEARCH

Neuroprotection by Manganese Superoxide Dismutase (MnSOD) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke

(2012) Hai-Feng Huang et al.   CNS Neuroscience & Therapeutics

Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice

(2012) Chang-Ming Chern et al.   FREE RADICAL BIOLOGY AND MEDICINE

Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase Cϵ

(2012) Usha Gundimeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minocycline-Preconditioned Neural Stem Cells Enhance Neuroprotection after Ischemic Stroke in Rats

(2012) H. Sakata et al.   JOURNAL OF NEUROSCIENCE

By Improving Regional Cortical Blood Flow, Attenuating Mitochondrial Dysfunction and Sequential Apoptosis Galangin Acts as a Potential Neuroprotective Agent after Acute Ischemic Stroke

(2012) Shaojing Li et al.   MOLECULES

Neuroprotection by the soy isoflavone, genistein, via inhibition of mitochondria-dependent apoptosis pathways and reactive oxygen induced-NF-κB activation in a cerebral ischemia mouse model

(2012) Yisong Qian et al.   NEUROCHEMISTRY INTERNATIONAL

The Mitochondria-Targeted Antioxidants and Remote Kidney Preconditioning Ameliorate Brain Damage through Kidney-to-Brain Cross-Talk

(2012) Denis N. Silachev et al.   PLoS One

Safety and Efficacy Evaluation of Carnosine, an Endogenous Neuroprotective Agent for Ischemic Stroke

(2012) Ok-Nam Bae et al.   STROKE

Intravenous autologous bone marrow mononuclear cells for ischemic stroke

(2011) Sean I. Savitz et al.   ANNALS OF NEUROLOGY

Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation

(2011) Guang-Lin Zhang et al.   BEHAVIOURAL PHARMACOLOGY

The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats

(2011) Hyo Won Jung et al.   Journal of Natural Medicines

Resveratrol prevents oxidative stress and inhibition of Na+K+-ATPase activity induced by transient global cerebral ischemia in rats

(2011) Fabrício Simão et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Melatonin protects against transient focal cerebral ischemia in both reproductively active and estrogen-deficient female rats: the impact of circulating estrogen on its hormetic dose-response

(2011) Shih-Huang Tai et al.   JOURNAL OF PINEAL RESEARCH

Human amniotic epithelial cells express melatonin receptor MT1, but not melatonin receptor MT2: a new perspective to neuroprotection

(2011) Yuji Kaneko et al.   JOURNAL OF PINEAL RESEARCH

Quercetin Protects Against Oxidative Stress Associated Damages in a Rat Model of Transient Focal Cerebral Ischemia and Reperfusion

(2011) Ajmal Ahmad et al.   NEUROCHEMICAL RESEARCH

Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion

(2011) Barry J. Connell et al.   NEUROSCIENCE LETTERS

Stem Cell Therapy as an Emerging Paradigm for Stroke (STEPS) II

(2011) Sean I. Savitz et al.   STROKE

Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies

(2011) Gregory W. Albers et al.   STROKE

Neuroprotective Effects of Leonurine on Ischemia/Reperfusion-Induced Mitochondrial Dysfunctions in Rat Cerebral Cortex

(2010) Jia Qi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Declining melatonin levels and MT1 receptor expression in aging rats is associated with enhanced mammary tumor growth and decreased sensitivity to melatonin

(2010) Steven M. Hill et al.   BREAST CANCER RESEARCH AND TREATMENT

Amniotic Membrane Patching Promotes Ischemic Rat Heart Repair

(2010) Anna Cargnoni et al.   CELL TRANSPLANTATION

Recent advances in the development of melatonin MT1and MT2receptor agonists

(2010) Marco Mor et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats

(2010) Lucrecia Regina G. Romeu et al.   FERTILITY AND STERILITY

NEURAL DIFFERENTIATION POTENTIAL OF RAT AMNIOTIC EPITHELIAL CELLS

(2010) Miki Shinya et al.   Fetal and Pediatric Pathology

Neuroprotective effect of Spirulina in cerebral ischemia–reperfusion injury in rats

(2010) Santhrani Thaakur et al.   JOURNAL OF NEURAL TRANSMISSION

Protective Effect of Melatonin upon Neuropathology, Striatal Function, and Memory Ability after Intracerebral Hemorrhage in Rats

(2010) Tim Lekic et al.   JOURNAL OF NEUROTRAUMA

In vitro and in vivo antitumor activity of melatonin receptor agonists

(2010) Lulu Mao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines

(2010) Jiraporn Tocharus et al.   JOURNAL OF PINEAL RESEARCH

Melatonin—A pleiotropic, orchestrating regulator molecule

(2010) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

Leonurine Protects Middle Cerebral Artery Occluded Rats Through Antioxidant Effect and Regulation of Mitochondrial Function

(2010) Kok Poh Loh et al.   STROKE

Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

(2010) Hsiao-Wen Lin et al.   Neuropsychiatric Disease and Treatment

Isolation of osteogenic progenitors from human amniotic fluid using a single step culture protocol

(2009) Ivana Antonucci et al.   BMC BIOTECHNOLOGY

Amnion: A Potent Graft Source for Cell Therapy in Stroke

(2009) Seong Jin Yu et al.   CELL TRANSPLANTATION

Edaravone (Radical Scavenger) versus Sodium Ozagrel (Antiplatelet Agent) in Acute Noncardioembolic Ischemic Stroke (EDO Trial)

(2009) Yukito Shinohara et al.   CEREBROVASCULAR DISEASES

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats

(2009) Mohd. Moshahid Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases

(2009) Xin Wang   CNS Neuroscience & Therapeutics

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Filtrate ofPhellinus linteusBroth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia

(2009) Sakiko Suzuki et al.   Evidence-based Complementary and Alternative Medicine

Therapeutic potential of melatonin in traumatic central nervous system injury

(2009) Supriti Samantaray et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improves presynaptic protein, SNAP-25, expression and dendritic spine density and enhances functional and electrophysiological recovery following transient focal cerebral ischemia in rats

(2009) Hung-Yi Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin promotes neurogenesis in dentate gyrus in the pinealectomized rat

(2009) Kerry Rennie et al.   JOURNAL OF PINEAL RESEARCH

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

(2009) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

(2009) Gerardo Ramírez-Rodríguez et al.   NEUROPSYCHOPHARMACOLOGY

Neuroprotective effect of parthenocissin A, a natural antioxidant and free radical scavenger, in focal cerebral ischemia of rats

(2009) Shan He et al.   PHYTOTHERAPY RESEARCH

Methazolamide and Melatonin Inhibit Mitochondrial Cytochrome C Release and Are Neuroprotective in Experimental Models of Ischemic Injury

(2009) Xin Wang et al.   STROKE

Ramelteon

(2008) Dene Simpson et al.   DRUGS

Role of melatonin receptors in the effects of melatonin on BDNF and neuroprotection in mouse cerebellar neurons

(2008) Marta Imbesi et al.   JOURNAL OF NEURAL TRANSMISSION

Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice

(2008) Ertugrul Kilic et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Regulates Nitric Oxide Synthase Expression in Ischemic Brain Injury

(2008) Phil-Ok KOH   JOURNAL OF VETERINARY MEDICAL SCIENCE

S tem Cell T herapies as an E merging P aradigm in S troke (STEPS)

(2008)   STROKE