HGF–MET Cascade, a Key Target for Inhibiting Cancer Metastasis: The Impact of NK4 Discovery on Cancer Biology and Therapeutics

Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607

(2012) Yao Dai et al.   BMC CANCER

Hepatocyte Growth Factor (HGF), an Endogenous Pulmotrophic Regulator, for the Rescue of Acute and Chronic Lung Diseases

(2012) Shinya Mizuno et al.   Current Signal Transduction Therapy

Targeting the HGF/Met signaling pathway in cancer therapy

(2012) Fabiola Cecchi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Fas Ligand Enhances Malignant Behavior of Tumor Cells through Interaction with Met, Hepatocyte Growth Factor Receptor, in Lipid Rafts

(2012) Huan-Ching Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Mannose Receptor as Receptor for Hepatocyte Growth Factor β-Chain

(2012) Hiroyuki Ohnishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

HGF-Induced PKCζ Activation Increases Functional CXCR4 Expression in Human Breast Cancer Cells

(2012) Songyin Huang et al.   PLoS One

Non-Agonistic Bivalent Antibodies That Promote c-MET Degradation and Inhibit Tumor Growth and Others Specific for Tumor Related c-MET

(2012) Sameer A. Greenall et al.   PLoS One

Anti-VEGF Therapy Revived by c-Met Inhibition, but Is c-Met the Answer?

(2012) Kristi D. Lynn et al.   Cancer Discovery

Differential roles of trans-phosphorylated EGFR, HER2, HER3 and RET as heterodimerisation partners of MET in lung cancer with MET amplification

(2011) J Tanizaki et al.   BRITISH JOURNAL OF CANCER

Head neck squamous cell carcinoma c-Met+ cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis

(2011) Shuyang Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Osthole Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial-Mesenchymal Transition via Repression of the c-Met/Akt/mTOR Pathway in Human Breast Cancer Cells

(2011) Chao-Ming Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Green tea (−)-epigallocatechin-3-gallate inhibits HGF-induced progression in oral cavity cancer through suppression of HGF/c-Met

(2011) Yoon Woo Koh et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists

(2011) Douglas S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor

(2010) B.-S. Pan et al.   CANCER RESEARCH

Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma

(2010) Yoshinori Suzuki et al.   INTERNATIONAL JOURNAL OF CANCER

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

The Tetraspanin CD151 Is Required for Met-dependent Signaling and Tumor Cell Growth

(2010) Mélanie Franco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels

(2010) Simone Buraschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Angiotensin IV Analog Nle-Tyr-Leu- -(CH2-NH2)3-4-His-Pro-Phe (Norleual) Can Act as a Hepatocyte Growth Factor/c-Met Inhibitor

(2010) B. J. Yamamoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The discovery of Hepatocyte Growth Factor (HGF) and its significance for cell biology, life sciences and clinical medicine

(2010) Toshikazu NAKAMURA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Hepatocyte growth factor protects endothelial cells against gamma ray irradiation-induced damage

(2009) Shun-ying Hu et al.   ACTA PHARMACOLOGICA SINICA

Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair

(2009) Nils Buchstein et al.   AMERICAN JOURNAL OF PATHOLOGY

Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models

(2009) Yuko Kishi et al.   CANCER SCIENCE

NK4, an HGF antagonist, prevents hematogenous pulmonary metastasis by inhibiting adhesion of CT26 cells to endothelial cells

(2009) Takeshi Kubota et al.   CLINICAL & EXPERIMENTAL METASTASIS

Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer

(2009) S. Krishnaswamy et al.   CLINICAL CANCER RESEARCH

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Gene transfer of NK4, an angiogenesis inhibitor, induces CT26 tumor regressionviatumor-specific T lymphocyte activation

(2009) Takeshi Kubota et al.   INTERNATIONAL JOURNAL OF CANCER

Increased production and secretion of HGF α-chain and an antagonistic HGF fragment in a human breast cancer progression model

(2009) Theodore G. Wright et al.   INTERNATIONAL JOURNAL OF CANCER

Angioinhibitory Action of NK4 Involves Impaired Extracellular Assembly of Fibronectin Mediated by Perlecan-NK4 Association

(2009) Katsuya Sakai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer

(2009) Jihong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors

(2009) Michalis V Karamouzis et al.   LANCET ONCOLOGY

CXCR4 and SDF-1 Production Are Stimulated by Hepatocyte Growth Factor and Promote Glioma Cell Invasion

(2009) Hanjun Tu et al.   ONKOLOGIE

Cyclooxygenase-2 Inhibition Inhibits c-Met Kinase Activity and Wnt Activity in Colon Cancer

(2008) J. B. Tuynman et al.   CANCER RESEARCH

Met Receptor Contributes to Trastuzumab Resistance of Her2-Overexpressing Breast Cancer Cells

(2008) D. L. Shattuck et al.   CANCER RESEARCH

Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor-Activating Mutations

(2008) S. Yano et al.   CANCER RESEARCH

Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer

(2008) Yoshihiko Kitajima et al.   CANCER SCIENCE

Augmented anti-tumor therapy through natural targetability of macrophages genetically engineered by NK4 plasmid DNA

(2008) T Okasora et al.   GENE THERAPY

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and β4 integrin function in MDA-MB-231 breast cancer cells

(2007) Wei-Jiunn Lee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY